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All Journal Buletin Farmatera Jurnal Ilmiah Kesehatan Media Husada Jurnal Kesehatan dan Kedokteran
Rambe, Ismatul Fauziah
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Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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DEOXYRIBONUCLEASE (DNAse) DAN INHIBITOR DNAse Rambe, Ismatul Fauziah; Yamamoto, Zulham
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.8984

Abstract

Deoxyribonuclease (DNAse) is an enzyme that plays an important role in cell apoptosis and has the function of hydrolyzing DNA. There are two types of DNAse, namely i) DNAse I which works well at neutral pH (6.5-8.0) and requires bivalent ions such as magnesium (Mg2+) and calcium (Ca2+) for activation, and ii) DNAse II which works by good at acidic pH and does not require bivalent ions. DNAse inhibitors are required to control the activity of DNAse. Both DNAse and its inhibitors have a role in the pathogenesis of various diseases, such as in the autoimmune disease systemic lupus erythematosus. DNase inhibitors can be obtained from natural, conventional, or chemical sources.
Intermittent Fasting and GERD Symptoms: A Cross-Sectional Study in a Medical Faculty Academic Community Putri, Cherry Permata; Rambe, Ismatul Fauziah
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 1 (2026): Februari: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i1.2581

Abstract

Gastroesophageal Reflux Disease (GERD) is a chronic gastrointestinal disorder caused by the backflow of gastric contents into the esophagus and may reduce quality of life. Intermittent fasting (IF) is increasingly practiced among productive-age groups, including academic communities, yet alterations in eating windows may influence gastric acid dynamics and gastrointestinal motility, making its relationship with GERD symptoms clinically relevant. Objective: This study aimed to examine the association between intermittent fasting habits and the occurrence of GERD symptoms among the academic community at the Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Sumatera Utara. Methodology: An analytic observational study with a cross-sectional design was conducted among 64 respondents selected using purposive sampling. Data were collected using a structured questionnaire and analyzed with SPSS. The association between IF habits and GERD symptoms was tested using the Chi-square test at a significance level of p < 0.05. Findings: The analysis showed no statistically significant association between intermittent fasting habits and GERD symptoms (p = 0.633). Research implications: These findings suggest that intermittent fasting, as practiced in this population, may not be a key determinant of GERD symptoms; therefore, prevention and counseling efforts should emphasize other modifiable factors (e.g., meal composition, late-night eating, stress, caffeine intake, or obesity-related risk) when managing reflux complaints in academic settings. Originality/value: This study provides context-specific evidence on the IF–GERD symptom relationship within an Indonesian medical faculty academic community using a standardized symptom assessment approach, contributing local data to an area where findings remain variable across populations.
CENTRAL OBESITY AS A RISK FACTOR FOR TYPE 2 DIABETES MELLITUS. Rambe, Ismatul Fauziah; Fellani, Brizelia Fellani; Octavia, Meta; Salsabila, Shafa
Jurnal Ilmiah Kesehatan Media Husada Vol 15 No 1 (2026): April
Publisher : LPPMK STIKES Widyagama Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33475/jikmh.v15i1.451

Abstract

Central Obesity, Characterized By The Accumulation Of Fat Around The Abdomen, Has Been Increasingly Recognized As A Significant Risk Factor For Type 2 Diabetes Mellitus (T2DM). This Systematic Review Aims To Evaluate Between Central Obesity And The Incidence Of T2DM. A Literature Search Was Conducted In July 2025 Using Databases Such As Pubmed, Google Scholar, And Ebsco. The Inclusion Criterias Are: Studies Published In The Last 10 Years, Available In Full Text, And Accessible For Free. Five Relevant Studies Were Reviewed And Synthesized. The Results Consistently Show That Indicators Of Central Obesity, Including Waist Circumference, Waist-To-Hip Ratio, Weight-Adjusted Waist Index (WWI), And Triglyceridemic Waist Phenotype, Are Strongly Associated With The Risk Of T2DM, Outperforming General Obesity Metrics Like BMI. The Visceral Fat Accumulation Plays A Critical Role In Insulin Resistance And Metabolic Dysfunction. These Results Draw Attention To The Value Of Central Obesity Measurements As Essential Components Of Early Detection And Prevention Strategies Aimed At Combating The Global Diabetes Burden.
Relationship Between Waist Circumference and Body Mass Index with HbA1c Levels in Patients with Type 2 Diabetes Mellitus Febriani, Sukma; Rambe, Ismatul Fauziah; Rahman, Shahrul; Siregar, Ren Astrid Allail
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 2 (2026): Juni: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i2.2657

Abstract

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and complex pathophysiological mechanisms. Obesity, assessed through Body Mass Index (BMI) and waist circumference (WC), is commonly associated with poor glycemic control, yet previous studies have reported inconsistent findings. Objective: This study aimed to analyze the relationship between waist circumference and BMI with HbA1c levels in patients with T2DM at Haji General Hospital Medan. Methods: A quantitative analytical study with a cross-sectional design was conducted involving 48 patients with T2DM who met the inclusion criteria. Anthropometric data, including BMI and WC, were measured directly, while HbA1c values were obtained from medical records. Bivariate analysis was performed using the Spearman correlation test, and multivariate analysis was conducted using ordinal logistic regression. Results: The analysis showed no significant association between waist circumference and HbA1c levels (r = −0.141; p = 0.339) or between BMI and HbA1c levels (r = 0.075; p = 0.611). Multivariate analysis also indicated that BMI and WC simultaneously did not significantly affect HbA1c categories (p > 0.05). Implications: These findings suggest that glycemic control in T2DM patients is influenced by multifactorial mechanisms beyond anthropometric parameters, highlighting the importance of considering behavioral, clinical, and therapeutic factors in diabetes management. Originality: This study provides context-specific evidence by simultaneously evaluating BMI and WC in a clinical outpatient population, contributing to the ongoing debate regarding the relevance of simple anthropometric indicators in predicting glycemic control.
Co-Authors Febriani, Sukma Fellani, Brizelia Fellani Octavia, Meta Putri, Cherry Permata Salsabila, Shafa Shahrul Rahman, Shahrul Siregar, Ren Astrid Allail Yamamoto, Zulham