Article Per Year (5 Year)
p-Index From 2020 - 2025
0.888
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Patologi Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Wresnindyatsih
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Ekspresi HPV16 Onkoprotein E7 pada Lesi Prakanker dan Karsinoma Sel Skuamosa Serviks Verli Saniba; Wresnindyatsih; Zulkarnain Musa; Zen Hafy
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.581 KB) | DOI: 10.55816/mpi.v29i2.409

Abstract

BackgroundCervical cancer is the secondmost common malignancy in women worldwide.The vast majority of cervical cancersare associatedwith high risk HPV16 infection. The persistence of HPV16 and integration of viral DNA into cell genome are necessary for thedevelopment of precancerous lesion and squamous cell carcinoma (SCC) of the cervix. The integration of viral DNA in the host cellgenome resulted in the regulation of oncoprotein E7 leading to detection of HPV16 E7 expression in precancerous lesions and SCCof the cervix.The aim of this study was to evaluate differences of HPV16 E7 expression in precancerous lesions and cervical SCC.MethodsAn observational study with cross-sectional design was performedat Department of Anatomical Pathology Faculty of MedicineUniversity of Sriwijaya/dr. Mohammad Hoesin General Hospital Palembang, from 1st July 2014 to 30st Juni 2017. The selectedsamples consisted of 25 precancerous cases lesions (13 cases of LSIL and 12 samples of HSIL) and SCC (25 cases).Immuhistochemical stained was conducted using HPV16 E7 antibody. Fisher exact’s test was used to analyze differences inexpression of HPV16 E7 among precancerous lesions and cervical SCC.ResultsThe pracancerous lesions occurred mostly between the ages of 30-40 years, while SCC were those between the ages of 51-60years. All SCC cases (100%) and 91.6% of HSIL showed weak to strong HPV16 E7 expression, and 84.6% cases of LSIL showedimmunonegative.ConclusionThe positivity of HPV16 E7 increased in HSIL and KSS lesions.
Analisis Ekspresi Fibroblast Activation Protein (FAP) terhadap Faktor Klinkopatologi dan Respon Kemoterapi pada Tumor Ganas Epitelial Ovarium Yunike Rinelda; Wresnindyatsih; Aida Farida Farida
Majalah Patologi Indonesia Vol 30 No 2 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.725 KB) | DOI: 10.55816/mpi.v30i2.468

Abstract

BackgroundEpithelial ovarian carcinoma is the most common cause of death among gynecological malignancies in the women. The interactionamong cancer cells and tumor microenvironment plays roles in cancer proliferation and invasiveness. One of important component oftumor microenvironment that could stimulate tumor proliferation and invasiveness, is fibroblast. Activated fibroblasts also known ascarcinoma associated fibroblasts (CAFs). The purpose of research is to analyzed FAP expressions to clinicopathologic characteristic(histopathology subtype and clinical stadium of FIGO) and chemotherapeutic responses.MethodsThis study is a retrospective observational analytic study with cross-sectional designs was undertaken during January 1, 2016 to June30, 2018. The sample was 55 paraffin block sample epithelial ovarian carcinomas consists of 11 samples for each histopathologysubtype collected used purposive sampling technique. All samples were immunostained with FAP antibody. FAP expressions wasevaluated based on Min Shi et al studies. It analyzed stained area/ proportion (P) and intensity (I). Statistical analysis using chi-squarewas performed using SPSS version 17.ResultsPatients of 40-49 years old (24; 43.6%), clinical stadium is III (30; 54.5%), Complete response (CR) of chemotherapeutic response(38; 69.1%). The statistic analyses between histopathology subtypes (p=0.038), clinical stadium of FIGO (p=0.000) and chemotherapyresponse (p=0.000) showed significant differences.ConclusionFAP expressions could showed correlation between clinicopathologic characteristic (histopathology subtype and clinical stadium ofFIGO) and chemotherapeutic response.
CCNE1 EXPRESSION AND CA-125 LEVELS IN HIGH GRADE SEROUS CARCINOMA OVARY AT MOHAMMAD HOESIN HOSPITAL PALEMBANG ; A SINGLE-INSTITUTION DESCRIPTIVE STUDY Fitriani, Dianli; Wresnindyatsih; Susilawati
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 2 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i2.671

Abstract

High grade serous carcinoma (HGSC) of the ovary is the dominant subtype causing death from ovarian cancer. CCNE1 amplification occurs in 20% of ovarian HGSC and is associated with recurrence after platinum chemotherapy. Assessment of CCNE1 expression can be a screening for CCNE1 amplification. Measurement of CA-125 levels is routinely used for treatment monitoring and recurrence of HGSC patients. This study aims to assess CCNE1 expression, demographic characteristics and CA-125 levels of ovarian HGSC patients. Of the 31 HGSC patients, the study subjects were dominated by patients aged >50 years (61.3%), clinical stage FIGO III (64.5%), CCNE1 overexpression (71%), preoperative CA-125 levels ≥500 U/ml (77.4%) and postchemotherapy CA-125 levels <35 U/ml (58.1%).
The expression of Ki-67 and clinicohistopathological characteristics of breast cancer in Southern Sumatra, Indonesia Harist, Muhammad; Wresnindyatsih; Fertilita, Soilia; Prasetyo, Nauval Togi; Abdurrachman, Muhammad Rafi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art6

Abstract

Background: Breast cancer is the most frequently diagnosed cancer in the world, approximately 2.3 million new cases (11.7% of all cancer cases) per year in 2020. The Ki-67 expression is clinically used to classify molecular subtypes of breast cancer into luminal A and luminal B groups.Objectives: This study aimed to investigate relationships between clinicohistopathological characteristics (ages, histopathological types, histopathological grades, molecular subtypes) of breast carcinoma patients and the Ki-67 proliferation index at dr. Moh. Hoesin General Hospital (RSMH) Palembang in 2019–2021.Method: This study applied an observational analytic study with a cross-sectional approach. 521 samples were included in this study based on inclusion and exclusion criteria. The samples in this study included invasive breast carcinoma patients who underwent histopathological examination and immunohistochemistry (IHC), recorded in the medical records at RSMH Palembang for 2019–2021 period. Then a statistical analysis was performed by using the chi-square test, which was analysed in the SPSS application.Results: The correlation between Ki-67 proliferation index and histopathological grades was statistically significant (p=0.018). The Ki-67 proliferation index was also statistically significantly associated with the molecular subtypes (p=0.000). Neither age (p=0.315) nor histopathological types (p=0.417) were significantly associated with the Ki-67 proliferation index.Conclusion: The Ki-67 expression was significantly associated with histopathological value and molecular subtype in breast carcinoma patients at RSMH Palembang in 2019–2021. The Ki-67 expression was not associated with the clinic-histopathological characteristics of ages and histopathological types.
Co-Authors Abdurrachman, Muhammad Rafi Aida Farida Farida Dian Fitriani Fertilita, Soilia Harist, Muhammad Prasetyo, Nauval Togi Susilawati Verli Saniba Yunike Rinelda Zen Hafy Zulkarnain Musa