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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Pengabdian Masyarakat Indonesia Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Folia Medica Indonesiana
Fertilita, Soilia
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Humanities Biochemistry, Genetics & Molecular Biology Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Pengaruh Ekstrak Daun Sirsak terhadap Ekspresi CD8 pada Populasi Limfosit Tumor Payudara Tikus Sparaque Dawley Fertilita, Soilia; Sandhika, Willy; Suprabawati, Desak Gede Agung
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 6, No 2 (2020): JMK Yayasan RS.Dr.Soetomo, Oktober 2020
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1162.081 KB) | DOI: 10.29241/jmk.v6i2.296

Abstract

Perubahan klinis pada payudara sebagian besar bersifat jinak, hanya 3 – 6% yang merupakan keganasan payudara. Namun demikian, kanker payudara menjadi perhatian utama mengingat angka kejadian yang terus menerus meningkat serta morbiditas dan mortalitas yang tinggi. Pengobatan kanker hingga saat ini masih menjadi tantangan. Hal ini membuka peluang penelitian terapi kanker terutama dari bahan herbal. Daun sirsak telah banyak digunakan masyarakat secara tradisional untuk pengobatan tumor. Di samping itu berbagai studi juga telah menunjukkan efek sitotoksik tanaman ini terhadap berbagi cell line kanker. Namun demikian belum ada penelitian yang menganalisis efek ekstrak daun sirsak terhadap populasi limfosit di lingkungan mikro tumor terutama yang berfungsi pada respon imun anti tumor. Penelitian ini bertujuan untuk mengetahui infiltrasi sel limfosit T CD8 pada jaringan tumor yang payudara tikus Sparaque Dawley yang diberikan ekstrak etanol daun sirsak. Ekspresi CD8 dianalisis melalui pewarnaan imunohistokimia. Ekspresi CD8 positif ditandai dengan warna coklat pada sitoplasma sel limfosit, selanjutnya ekspresi CD8 dari setiap sampel dihitung pada 3 lapang pandang dengan high-power field, kemudian ditentukan nilai rata-ratanya. Pewarnaan HE menunjukkan variasi infiltrasi limfosit pada nodul payudara tikus SD. Rata-rata ekspresi CD8 kelompok kontrol menunjukkan hasil lebih tinggi dibandingkan kelompok perlakuan. Namun demikian, hasil uji komparasi menunjukkan tidak ada perbedaan bermakna  (p > 0,05) antara ekspresi CD8 kelompok kontrol dengan perlakuan. Hasil ini menunjukkan bahwa pemberian ekstrak daun sirsak tidak menyebabkan perbedaan bermakna ekspresi CD8 pada populasi limfosit yang menginfiltrasi tumor payudara tikus SD.  
Effectiveness of Cherry Tomato Extract in Gel Form to Accelerate the Healing Process of Excision Wounds in Wistar White Rats Fertilita, Soilia; Zulfadli, Muhammad; Larasati, Veny; Rasyid, Riana Sari Puspita; Argentina, Fifa; Tanta, Yudhi; Athiah, Medina
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.427-434

Abstract

Cherry tomatoes (Solanum lycopersicum L. var. cerasiforme) are rich in antioxidants, particularly flavonoids and lycopene, which help reduce free radicals and promote wound healing. Flavonoids exhibit anti-inflammatory, antioxidant, antibacterial, and antidiabetic properties. They enhance wound contraction, collagen deposition, granulation tissue formation, and epithelialization in wound healing. This study evaluates the efficacy of cherry tomato extract gel in accelerating excision wound healing in Wistar rats. This in vivo experimental study used a post-test control group design. Twenty-five 2–3-month-old Wistar rats with excision wounds were treated with cherry tomato extract gel or controls. The five groups included a positive control (NaCl), a negative control (CMC-Na gel), and treatment groups receiving 8%, 12%, or 16% extract gel. Wound size was measured on days 3, 5, 7, and 9, with data analyzed using One-Way ANOVA and post hoc tests. The extract-treated groups exhibited nearly complete wound closure by day 9. The wound size of the treatment groups significantly differed from the control groups (p<0.05). Cherry tomato extract gel significantly accelerates wound closure at 8%, 12%, and 16% concentrations, with the best results observed at 16% (p<0.05), surpassing even the positive control. The 16% extract gel group demonstrated the most effective wound healing. Cherry tomato extract gel significantly enhances wound healing, with the 16% concentration demonstrating the most effective acceleration of wound closure. These findings suggest that cherry tomato extract gel, particularly at 16%, holds promise as a potent wound-healing agent.
Pemberdayaan Masyarakat Desa Ulak Kerbau Baru dalam Penyusunan Program Toga melalui Perkuliahan Terintegrasi Solihah, Indah; Shiyan, Shaum; Puspita Rasyid, Rianasari; Fertilita, Soilia
Jurnal Pengabdian Masyarakat Indonesia Vol 5 No 4 (2025): JPMI - Agustus 2025
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.3736

Abstract

Pengetahuan masyarakat desa Ulak Kerbau Baru, kecamatan Tanjung Raja, kabupaten Ogan Ilir, Sumatera Selatan masih rendah. Peningkatan keilmuan masyarakat terkait cara penggunaan tanaman obat yang benar, dari segi ketepatan bahan, takaran, cara penggunaan, khasiat, dan keamanannya perlu dilakukan. Metode yang digunakan dapat melalui kegiatan perkuliahan terintegrasi pada mata kuliah Obat Tradisional yang ada di Jurusan Farmasi FMIPA UNSRI. Penggunaan lahan kosong yang tidak produktif sebagai lahan TOGA yang diinisiasi melalui Kepala Desa dan perangkatnya. Lahan yang telah disepakati selanjutnya akan diolah menjadi lahan TOGA dengan penanaman beberapa tanaman obat dengan variasi penggunaan tanaman yang dimanfaatkan bagian daun, bunga, buah, dan rimpang. Penunjukkan kader TOGA melalui musyawarah dengan masyarakat dan perangkat desa untuk menjaga dan merawat TOGA yang sudah dibentuk. Proses penanaman dan pemeliharaan tanaman obat pada TOGA melibatkan mahasiswa dan kader TOGA yang telah ditunjuk. Pasca kegiatan penyuluhan terlihat adanya peningkatan pengetahuan masyarakat setelah diberikan penyuluhan terkait TOGA, budidaya tanaman obat, serta manfaat tanaman obat.
Comparison of anti-SARS-CoV-2 IgG seropositivity among vaccinated, unvaccinated, and COVID-19 survivor individuals: A cross-sectional study in Palembang, Indonesia Retnaningsih, Ekowati; Nuryanto, Nuryanto; Oktarina, Reni; Komalasari, Oom; Maryani, Sri; Larasti, Veny; Fertilita, Soilia
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2890

Abstract

Measurement of anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody levels provides evidence of prior infection or vaccination. Persistent vaccine hesitancy underscores the importance of robust, evidence-based data to inform policy decisions. The aim of this study was to compare anti-SARS-CoV-2 IgG seropositivity among vaccinated individuals, unvaccinated individuals, and coronavirus disease 2019 (COVID-19) survivors in the community during the pandemic. In this cross-sectional study, 517 participants were enrolled, including 167 vaccinated individuals, 97 COVID-19 survivors, and 253 unvaccinated individuals, selected through multistage cluster sampling of 40 clusters. Anti-SARS-CoV-2 IgG seropositivity was defined as ≥50 AU/mL. Multivariable logistic regression was performed to evaluate associations between group type and seropositivity, adjusting for demographic factors, COVID-19 symptoms, hypertension, and body mass index (BMI). Vaccinated individuals demonstrated significantly higher odds of seropositivity compared with unvaccinated participants (odds ratio (OR)=5.60; 95% confidence interval (CI): 2.36–13.27). Covariates independently associated with seropositivity (p<0.05) included the presence of COVID-19 symptoms, hypertension, and BMI. Vaccination was strongly associated with increased anti-SARS-CoV-2 IgG seropositivity in the community, independent of clinical and demographic factors. These findings support ongoing vaccination campaigns and highlight the relevance of comorbidities and symptomatic history in shaping humoral immune responses.
The expression of Ki-67 and clinicohistopathological characteristics of breast cancer in Southern Sumatra, Indonesia Harist, Muhammad; Wresnindyatsih; Fertilita, Soilia; Prasetyo, Nauval Togi; Abdurrachman, Muhammad Rafi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 2, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss2.art6

Abstract

Background: Breast cancer is the most frequently diagnosed cancer in the world, approximately 2.3 million new cases (11.7% of all cancer cases) per year in 2020. The Ki-67 expression is clinically used to classify molecular subtypes of breast cancer into luminal A and luminal B groups.Objectives: This study aimed to investigate relationships between clinicohistopathological characteristics (ages, histopathological types, histopathological grades, molecular subtypes) of breast carcinoma patients and the Ki-67 proliferation index at dr. Moh. Hoesin General Hospital (RSMH) Palembang in 2019–2021.Method: This study applied an observational analytic study with a cross-sectional approach. 521 samples were included in this study based on inclusion and exclusion criteria. The samples in this study included invasive breast carcinoma patients who underwent histopathological examination and immunohistochemistry (IHC), recorded in the medical records at RSMH Palembang for 2019–2021 period. Then a statistical analysis was performed by using the chi-square test, which was analysed in the SPSS application.Results: The correlation between Ki-67 proliferation index and histopathological grades was statistically significant (p=0.018). The Ki-67 proliferation index was also statistically significantly associated with the molecular subtypes (p=0.000). Neither age (p=0.315) nor histopathological types (p=0.417) were significantly associated with the Ki-67 proliferation index.Conclusion: The Ki-67 expression was significantly associated with histopathological value and molecular subtype in breast carcinoma patients at RSMH Palembang in 2019–2021. The Ki-67 expression was not associated with the clinic-histopathological characteristics of ages and histopathological types.
The Effects of Intermittent Fasting on the Size and Number of Subcutaneus Adipocytes in Obese Mouse Models Larasati, Veny; Rasyid, Riana Sari Puspita; Fertilita, Soilia; Suciati, Tri; Farhan, Muhammad
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. This study helps bridge the gap between systemic effects and tissue-level changes, providing a deeper understanding of how histological analysis can be used to explore the effects of intermittent fasting on adipocytes and body weight regulation. 2. This study contributes to obesity management through lifestyle modification, specifically intermittent fasting, by focusing on histological changes in adipose tissue. Abstract The accumulation of adipose tissue can have deleterious effects and lead to obesity. Intermittent fasting (IF), an approach that involves time-restricted eating, has gained popularity as an obesity treatment option because it enhances insulin sensitivity and promotes beneficial changes in glucose metabolism. This study used a time-restricted meal intake (TRM) approach to assess the effects of IF on the histological features of obese mouse models' subcutaneous inguinal adipose tissue. The investigation employed an in vivo experimental posttest-only control group design. Twenty male mice were divided into four groups: a normal control group, an obese control group, a TRM group with a high-fat diet (TRM-HF), and a TRM group with a standard diet (TRM-S). The TRM treatment was administered for fourteen days, with a fasting window from 4 p.m. to 8 a.m. The pre- and post-treatment weight analyses were conducted using the paired t-test for normally distributed data and the Wilcoxon test for non-normally distributed data (p<0.05). One-way analysis of variance (ANOVA) was employed for unpaired data on the post-treatment weight. Per field of view, there were an average of 120,500 cells (49,700–136,200) in the normal control group, 68,380±9,194 cells in the obese control group, 70,860±11,029 cells in the TRM-HF group, and 79,360±5,112 cells in the TRM-S group. The average cell sizes (μm3) were 56,730.142±19,273.257 in the normal control group, 138,934.331±27,670.558 in the obese control group, 106,827.767±20,580.501 in the TRM-HF group, and 68,689.114±8,219.727 in the TRM-S group. The number of cells in each group did not differ significantly, but there were significant variations in cell size. The mice receiving TRM treatment did not exhibit substantial body weight changes, whereas the obese control group showed a significant body weight increase. In conclusion, TRM has an effect on cell size but does not affect the quantity of adipocytes in subcutaneous inguinal fat tissue.
Co-Authors Abdurrachman, Muhammad Rafi Athiah, Medina Ekowati Retnaningsih Fifa Argentina Harist, Muhammad Larasati, Veny Larasti, Veny Maryani, Sri Muhammad Farhan Nuryanto Nuryanto Oom Komalasari Prasetyo, Nauval Togi Puspita Rasyid, Rianasari Rasyid, Riana Sari Puspita Reni Oktarina Shaum Shiyan Solihah, Indah Suprabawati, Desak Gede Agung Tanta, Yudhi Tri Suciati Willy Sandhika Wresnindyatsih Zulfadli, Muhammad