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Hernowo, Bethy Surjawathy
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Health Professions Public Health

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Karakteristik Pasien Lesi Prakanker Serviks di Rumah Sakit Tersier Jawa Barat, Indonesia Maulana, Akbar; Dewayani, Birgitta Maria; Hernowo, Bethy Surjawathy
Majalah Patologi Indonesia Vol. 31 No. 2, Mei 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i2.504

Abstract

BackgroundThe incidence of cervical cancer was continues to increase even though various risk factors and prevention efforts have been made.Cervical cancer begins with the development of a precancerous lesion (Cervical Intraepithelial Neoplasia/CIN) which is an abnormalcell growth in the cervical epithelium. This study aims to see the proportion of risk factors for cervical cancer in CIN patients at Dr.Hasan Sadikin, Bandung.MethodsThis study used a cross-sectional retrospective descriptive research method using secondary data of CIN patients for the periodJanuary 2016 - December 2020 from the archives of the anatomical pathology laboratory and clinical medical records of patients inthe form of age, marriage history, total parity, age at marriage, age at menarche, usage of hormonal contraceptives, smoking habits,clinical symptoms and histopathological degrees.ResultThere were total sample 40 cases of CIN. The 41-50 year age category is the largest age range of all NIS cases (35%). The resultsof this research data were history of marriage 1x (85%), age at marriage in the range of 20-30 years (47.5%), history of menarche inthe age range 10-15 years (90%), history of multiparous (65%), used of hormonal contraceptives (52.5%), non-smoking habits(67.5%), clinical symptoms of vaginal bleeding (42.5%) and histopathological grade of CIN 1 (47.5%).ConclusionCervical precancerous lesions at RSUP Dr. Hasan Sadikin occurred between fourth and fifth decades of life with a history of beingmarried once, multiparous, married at the age of 20-30 years, menarche at the age of 10-15 years, using hormonal contraception,not smoking, complaints of vaginal bleeding and the majority of cases were CIN 1.
Analisis Karakter Klinikopatologik pada Kasus Karsinoma Payudara Subtipe Luminal A Like Susanto, Andi; Dewayani,, Birgitta Maria; Hernowo, Bethy Surjawathy
Majalah Patologi Indonesia Vol. 30 No. 3, September 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i3.477

Abstract

BackgroundMolecular subtypes of breast carcinoma, luminal A like has the best prognosis, but in the previous studies there were cases thatshowed poor clinical outcomes. This study attempted to investigate the clinicopathological characteristics in luminal A like subtypebreast carcinoma.MethodsThis study is a cross sectional study. The samples used were 67 medical records of patients with luminal A like subtype breastcarcinoma in January 2014 to June 2019 period from Hasan Sadikin Hospital, Bandung. According to estrogen receptor (ER) andprogesteron receptor (PR) expression status by adding both intensity and distribution scores, the data were divided into twosubgroups: low histoscore (<7) and high histoscore (≥7). Clinicopathological characteristics (age, TNM stage, treatment, location,histologic type, grading and metastasis) were evaluated for each subgroup.ResultsFrom 67 luminal A like subtype breast carcinoma patients, 73.13% were in the high histoscore subgroup, with higher percentage oflow grade histopathologic features (63.27%). There were no significant differences in age and TNM staging between the twosubgroups. Among 67 breast carcinoma patients, 43 were diagnosed in advanced stages. There were significant differences inlymph nodes metastasis between the two subgroups (p-value 0.013), however, there were no significant difference in metastasis toother organs.ConclusionThis study shows that 73.13% of patients with luminal A like subtype breast carcinoma have a high histoscore of hormone receptor.Low histoscore subgroups luminal A like subtype breast carcinoma will metastasize to lymph nodes.
Co-Authors Andi Susanto Dewayani, Birgitta Maria Dewayani,, Birgitta Maria Maulana, Akbar