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All Journal Althea Medical Journal Jurnal Kesehatan Andalas Indonesian Journal of Obstetrics & Gynecology Science Majalah Patologi Indonesia Jurnal Integrasi Kesehatan dan Sains Jurnal Locus Penelitian dan Pengabdian
Dewayani, Birgitta Maria
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Aerospace Engineering Automotive Engineering Decision Sciences, Operations Research & Management Dentistry Electrical & Electronics Engineering Health Professions Mathematics Medicine & Pharmacology Nursing Public Health

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Association of Nuclear VDR Immunoexpression with Breslow’s Thickness in Acral Melanoma Sholihah, Fitria; Usman, Hermin Aminah; Dewayani, Birgitta Maria
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.2801

Abstract

Background: Acral melanoma (AM) is a subtype of malignant melanoma (MM) that has a predilection for glabrous skin and is the most common type of melanoma among Asians. Depth of invasion is one of the prognostic factors in AM. VDR may have an association with depth of invasion in AM. However, reports from Asian patients are still lacking. The aim of this study was to explore the association between VDR immunoexpression and depth of invasion in AM patients in Bandung, Indonesia.Methods: This study was a retrospective cross-sectional study that analyzed the nuclear and cytoplasm VDR expression of melanoma cells and its association with Breslow’s thickness in patients with AM in Dr. Hasan Sadikin General Hospital Bandung. VDR immunostaining was performed on paraffin blocks. The Breslow thickness was measured using dot slide software. Chi square statistical analysis was done to determine the results.Results: Of the 30 patients, 73% had a Breslow thickness of >4 mm.  There was a significant inverse association between nuclear VDR immunoexpression and Breslow thickness of AM (p<0.001), but not for cytoplasmic VDR immunoexpression (p=0.914). Conclusion: Low nuclear VDR immunoexpression is associated with the depth of invasion in AM. Nuclear VDR immunoexpression possibly affect progression and should be considered before administration of vitamin D therapy in AM. 
Peran Magnetic Resonance Imaging pada Diagnosis Kanker Serviks yang Menyerupai Kanker Endometrium – Laporan Kasus Erfiandi, Febia; Harsono, Ali Budi; Soekersi, Hari; Dewayani, Birgitta Maria; Kireina, Jessica
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.444

Abstract

Pendahuluan: Magnetic resonance imaging (MRI) merupakan modalitas penting dalam diagnosis kanker ginekologi, terutama serviks dan endometrium. Laporan kasus ini bertujuan melihat peranan MRI dalam menentukan asal tumor, keterlibatan parametrium, dan metastasis kelenjar getah bening retroperitoneal.Presentasi Kasus: Pada laporan kasus ini pasien didiagnosis kanker serviks stadium IB3 dengan diagnosis banding kanker endometrium stadium II karena keluhan perdarahan pasca-menopause, massa di serviks bersifat endofitik, dan ukuran uterus membesar. Hasil histopatologi kuretase yaitu endometrioid endometrial carcinoma moderately differentiated Dd/adenocarcinoma cervix. Magnetic resonance imaging (MRI) dilakukan untuk melihat asal tumor dan menetukan stadium. Skor MRI menganalisis tujuh perbedaan fitur: lokasi dan perfusi tumor, penyengatan perifer, massa atau distensi rongga endometrium, invasi miometrium, dan infiltrasi jaringan sekitar; skor 10 didapatkan pada kasus dengan menggunakan sekuens T2WI sagital, DWI-ADC, dan DCE yang menyimpulkan bahwa tumor berasal dari serviks dan telah menginfiltrasi parametrium.Kesimpulan: Skor MRI bisa dijadikan pertimbangan untuk melihat asal tumor (serviks atau endometrium) selain melihat keterlibatan parametrium dan kelenjar getah bening pelvis sehingga diagnosis dan manajemen lebih baik.The Role of Magnetic Resonance Imaging in the Diagnosis of Cervical Cancer Resembling Endometrial Cancer – A Case ReportAbstractObjective: Magnetic resonance imaging (MRI) is an important modality in the diagnosis of gynecological cancer, especially cervical and endometrial cancer. This case report aims to examine the role of MRI in determining tumor origin, parametrial involvement, and retroperitoneal lymph node metastases.Case presentation: In this case report, the patient was diagnosed with stage IB3 cervical cancer Dd/ stage II endometrial cancer due to complaints of postmenopausal bleeding, endophytic cervical mass, and uterine enlargement. The histopathological results of curettage were moderately differentiated endometrioid endometrial carcinoma Dd/adenocarcinoma of the cervix. Magnetic resonance imaging (MRI) is performed to determine the origin of the tumor and its stage. MRI score was analyzed for seven distinct features: tumor location and perfusion, peripheral rim, endometrial cavity mass or distension, invasion of the myometrium, and surrounding organs infiltration; score of 10 was obtained in these cases using sagittal T2WI, DWI-ADC, and DCE sequence which concluded that the tumor was cervical origin and had infiltrated the parametrium.Conclusion: MRI score can be considered to see the origin of the tumor (cervical or endometrial) in addition look for involvement of the parametrium and pelvic lymph nodes so that diagnosis and management will be better.Key words: Magnetic Resonance Imaging, Cervical Cancer, Endometrial Cancer, Gynecological Cancer, Parametrial Infiltration
Insidensi Bayi Berat Lahir Rendah pada Spektrum Plasenta Akreta di Rumah Sakit Dr Hasan Sadikin Bandung Kharisma, Yuktiana; Agustina, Hasrayati; Suryanti, Sri; Dewayani, Birgitta Maria; Hernowo, Bethy Suryawati
Jurnal Kesehatan Andalas Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.2063

Abstract

Low birth weight (LBW) babies are closely related to infant morbidity, stunted growth and cognitive development, and chronic diseases. Placenta accreta spectrum (PAS) is a condition that complicates pregnancy and is closely related to low birth weight. Objectives: To determined the incidence of LBW in mothers with SPA at the hospital Dr. Hasan Sadikin Bandung. Methods: A descriptive observational study involving 71 cases of SPA in hospitals  Dr. Hasan Sadikin Bandung, period 2016-2020, which has met the inclusion and exclusion criteria. SPA cases were divided into three groups: placenta accreta, increta, and percreta. In each SPA group, the incidence of LBW was evaluated. Results: 46.5% (33/71 cases of PAS) had low birth weight, while 53.5% (38/71 cases of PAS) had normal birth weight babies. The placenta accreta and percreta groups were dominated by normal birth weight infants [(18/31 cases), (5/9 cases)], while the placenta increta group was dominated by low birth weight infants (16/31 cases). The LBW category is divided into Extremely Low Birth Weight (ELBW), Very Low Birth Weight (VLBW), and LBW. In placenta accreta, there were 2 ELBW and VLBW infants, and 9 LBW infants. In the placenta increta, there are 3 ELBW and VLBW, and 10 LBW. In the placenta percreta, there were 1 ELBW and 3 LBW, while VLBW was not found in the placenta percreta. Conclusion: The incidence of LBW is found in almost half the population of SPA cases in hospitals. DR. Hasan Sadikin in the 2016-2020 period.Keywords:  low birth weight, placenta accreta spectrum
Neuroendocrine Carcinoma of The Uterine Cervix: Clinicopathological Profile and Outcomes From a Tertiary Referral Center in Indonesia Permatasari, Anita; Dewayani, Birgitta Maria; Yantisetiasti , Anglita
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 9 (2025): : JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i9.4856

Abstract

Neuroendocrine carcinoma of the cervix (NECC) is a rare and aggressive cervical malignancy with poor prognosis. Data from Indonesia remain scarce. We retrospectively reviewed 55 cases of NECC diagnosed at Dr. Hasan Sadikin General Hospital, Bandung, between 2019 and 2025. Clinicopathological data included age, International Federation of Gynecology and Obstetrics (FIGO) stage, histologic subtype, lymphovascular invasion (LVI), and metastatic status. Overall survival (OS) was estimated using Kaplan–Meier analysis. Patients’ ages ranged from 24 to 82 years, with a median age of 46 years. Most cases were diagnosed at locally advanced stages (FIGO II–III, 54.5%), while 14 patients (25.5%) presented with distant metastatic disease (IVB). Small cell NECC was the predominant subtype, while large cell and admixed variants were less frequent. LVI was present in more than half of the cases. Distant metastases at diagnosis were identified in the lungs, bone, and liver. At the last follow-up, 25 patients (45.4%) had died. Kaplan–Meier analysis revealed a median OS of 14.5 months, with 1-year survival of 52% and 2-year survival of 42%. NECC in Indonesia presents mostly at locally advanced stages, with high rates of LVI and frequent metastases, leading to poor survival. These findings highlight the aggressive course of NECC and provide baseline data for future studies in Indonesia.
Clinicopathologic Characteristics of Ovarian Carcinoma in Hasan Sadikin General Hospital Bandung Suryajaya, Bernard Santoso; Yantisetiasti, Anglita; Dewayani, Birgitta Maria
Majalah Patologi Indonesia Vol. 34 No. 3 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Background: Ovarian carcinoma (OC) has several subtypes with overlapping histopathological presentation and usually has a poor prognosis. According to WHO, ovarian Mucinous Carcinoma (MC) is the most common subtype of OC in Southeast Asia, especially Indonesia. Objectives: This study aimed to report the incidence and clinicopathologic characteristics of OC between 2018-2023 tertiary Hospital in Bandung, Indonesia Materials and Methods: We conducted a descriptive study, collecting OC data from medical records in Hasan Sadikin General Hospital, a tertiary referral hospital. Results: The most common subtypes from 460 patients were MC (n=460;32%) based on histomorphology and immunohistochemistry, followed by Ovarian Endometrioid Carcinoma (EC) (n=460;21%). The mean age was 47.89 years (range 14-81). We revealed EC's incidence was higher than ovarian High-Grade Serous Carcinoma (HGSC) (21% vs. 18%), discordant with the WHO report as the most common subtype. The largest OC reported was 70 cm in the greatest dimension found in MC, and the smallest OC was 3 cm found in Ovarian Clear Cell Carcinoma. Conclusion: The most common subtype of ovarian carcinoma was ovarian mucinous carcinoma; the overall mean age was 47.89 years. The largest ovarian carcinoma was mucinous carcinoma, with 70 cm in the greatest dimension.
Hubungan Karakteristik dengan Tingkat Pengetahuan Perempuan Usia Reproduktif mengenai Berat Badan Lahir Rendah dan Spektrum Plasenta Akreta pada Salah Satu Komunitas Perguruan Tinggi Swasta di Bandung Agustina, Hasrayati; Dewayani, Birgitta Maria; Suryanti, Sri; Hernowo, Bethy Suryawaty; Kharisma, Yuktiana
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 1 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i1.11816

Abstract

Berat badan lahir rendah (BBLR) dan spektrum plasenta akreta (SPA) merupakan salah satu masalah kesehatan yang menyebabkan morbiditas serta mortalitas ibu dan janin yang signifikan. Pengetahuan tentang kesehatan sangat penting untuk mengurangi efek buruk tersebut. Penelitian bertujuan mengetahui tingkat pengetahuan perempuan usia reproduktif mengenai BBLR dan SPA. Studi potong lintang berbasis masyarakat tersebut dilakukan pada bulan Agustus 2021 pada 65 partisipan komunitas usia reproduktif pada salah satu perguruan tinggi swasta di Bandung melalui pengisian kuesioner yang telah tervalidasi. Analisis data menggunakan uji chi-square melalui perangkat lunak STATA versi 15 untuk mengevaluasi hubungan antara karakteristik partisipan dengan tingkat pengetahuan BBLR dan SPA. Hasil penelitian sebanyak 54% partisipan memiliki pengetahuan BBLR dan SPA itu cukup.  Terdapat hubungan signifikan karakteristik pekerjaan (p=0,02) dengan tingkat pengetahuan BBLR dan SPA, sedangkan karakteristik usia (0,009), status pernikahan (0,24), dan pendidikan (0,2) tidak berhubungan dengan tingkat pengetahuan mengenai BBLR dan SPA. Terdapat beberapa faktor yang memengaruhi pengetahuan, seperti usia, pendidikan, sosial budaya, ekonomi, lingkungan, serta pekerjaan. Simpulan, pemberian stimulus berupa informasi seputar BBLR dan SPA melalui kegiatan sosialisasi yang berkesinambungan diharapkan dapat menjadi salah satu solusi untuk meningkatkan pengetahuan pada komunitas perempuan usia reproduktif AbstractLow birth weight (LBW) and placenta accreta spectrum (PAS) are health problems that cause significant maternal and fetal morbidity and mortality. Health knowledge is very important to reduce these adverse effects. This study aims to determine the level of knowledge of women of reproductive age about LBW and PAS. The cross-sectional community-based study was conducted in August 2021 on 65 participants of the reproductive age community at a private university in Bandung by filling out a validated questionnaire. Data analysis used the Chi-Square test by STATA software version 15 to evaluate the association between participant characteristics and knowledge level of LBW and PAS. The results showed that most of the participants had sufficient knowledge of LBW and PAS (54%). There was a significant relationship between job characteristics (p=0.02) and the level of knowledge of LBW and SPA, while the characteristics of age (0.009), marital status (0.24), and education (0.2) are not related to the level of knowledge of LBW and SPA. Several factors influence knowledge, such as age, education, socio-culture, economy, environment, and work. In conclusion, health education in the form of information about LBW and PAS through continuous counseling is expected to be one of the solutions to increase knowledge in the community.
Co-Authors Anglita Yantisetiasti Anita Permatasari Bethy Suryawati Hernowo Erfiandi, Febia Hari Soekersi Harsono, Ali Budi Hasrayati Agustina Hermin Aminah Usman Hernowo, Bethy Suryawaty Kireina, Jessica Sholihah, Fitria Sri Suryanti Suryajaya, Bernard Santoso Yantisetiasti , Anglita Yuktiana Kharisma