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Complex Compound with Transitional Metal of Akway Bark (Drimys piperita Hook f.) as Low Molecular Weight Scavenging Antioxidant: a Computational Study Hutasoit, Hostalige; Djoko, Dionysius Joseph; Sumitro, Sutiman B; Widjanarko, Simon Bambang
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.02

Akway (Drimys piperita Hook f.) was known as an endogenous plant of Indonesia. This plant was investigated as free radical scavenger based on paramagnetic properties. This study aimed to identify the bioactive compound and the role of Fe metals ions to enhance the free radical scavenger capacity as Low molecular weight antioxidant (LWMA) of akway. This study was designed by ultra-performance liquid chromatography (UPLC) coupled with ultra-high-resolution time of flight-mass spectrometry detector (TOF-MS), docking (Pyrex and Discovery Studio 2016 Client) and pharmacokinetic properties prediction (SwissADME). UPLC-TOF-MS analysis showed that herbal akway bark has five molecular formula (C4H3N10O21-, C14H19N4O91-, C4H7N6O51-, C15H28NO31+, and C23H32NO71+). The docking was illustrated the complex binding akway formula with Fe and its role as a metal donor and metal acceptor. It also confirmed on pharmacokinetics properties prediction which molecular compounds of akway have aqueous solubility. It meant the herbal akway bark complexed to Fe could be a low molecular weight antioxidant and it could be escalated free radical scavenger capacity.

Sifat Fisik, Kandungan Fitokimia dan Aktivitas Antibakteri Minyak Essensial Kulit Batang Akway (Drimys piperita Hook f.) Muhammad Zakariyah; Gino Nemesio Cepeda; Hostalige Hutasoit
Agritechnology Vol 1 No 2 (2018): Edisi Desember
Publisher : Fakultas Teknologi Pertanian, Universitas Papua, Manokwari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51310/agritechnology.v1i2.18

Minyak essensial merupakan produk cairan yang diperoleh melalui proses ekstraksi dari berbagai bagian tumbuhan aromatik. Akway (Drimys piperita Hook f.) merupakan salah satu jenis tumbuhan aromatik yang memiliki kulit batang yang mengandung minyak essensial. Konsentrasi dan jenis senyawa penyusun minyak essensial sangat menentukan sifat fisik, kimia dan antibakterinya. Penelitian ini bertujuan untuk menentukan sifat fisik dan kandungan fitokimia minyak essensial kulit batang akway serta potensi antibakterinya terhadap pertumbuhan bakteri patogen. Proses ekstraksi minyak essensial kulit batang akway dilakukan menggunakan metode distilasi air. Pengujian sifat fisik yang dilakukan meliputi warna, kelarutan dalam alkohol dan indeks refraktif sedangkan pengujian kandungan kualitatif fitokimianya meliputi terpenoid, flavonoid, alkaloid dan saponin. Pengujian aktivitas antibakteri dilakukan pada konsentrasi 0-10% dengan metode difusi cakram di dalam medium agar. Hasil menunjukkan bahwa minyak essensial kulit batang akway memiliki warna jernih kekuningan, kelarutan 1 : 2 dalam alkohol 80%, dan indeks refraktif sebesar 1,4942. Minyak essensial kulit batang akway mengandung terpenoid, flavonoid, alkaloid dan saponin serta dapat menghambat pertumbuhan bakteri patogen dengan konsentrasi hambat tumbuh minimum sebesar 2,7-5,0 mg/ml.

Complex Compound with Transitional Metal of Akway Bark (Drimys piperita Hook f.) as Low Molecular Weight Scavenging Antioxidant: a Computational Study: Complex Compound of AkwayBark as Scavenging Antioxidant Hostalige Hutasoit; Dionysius Joseph Djoko; Sutiman B Sumitro; Simon Bambang Widjanarko
Journal of Tropical Life Science Vol. 11 No. 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.02

Akway (Drimys piperita Hook f.) was known as an endogenous plant of Indonesia. This plant was investigated as free radical scavenger based on paramagnetic properties. This study aimed to identify the bioactive compound and the role of Fe metals ions to enhance the free radical scavenger capacity as Low molecular weight antioxidant (LWMA) of akway. This study was designed by ultra-performance liquid chromatography (UPLC) coupled with ultra-high-resolution time of flight-mass spectrometry detector (TOF-MS), docking (Pyrex and Discovery Studio 2016 Client) and pharmacokinetic properties prediction (SwissADME). UPLC-TOF-MS analysis showed that herbal akway bark has five molecular formula (C4H3N10O21-, C14H19N4O91-, C4H7N6O51-, C15H28NO31+, and C23H32NO71+). The docking was illustrated the complex binding akway formula with Fe and its role as a metal donor and metal acceptor. It also confirmed on pharmacokinetics properties prediction which molecular compounds of akway have aqueous solubility. It meant the herbal akway bark complexed to Fe could be a low molecular weight antioxidant and it could be escalated free radical scavenger capacity.

Karakterisasi Senyawa Caulersin, Caulerpol, Caulerpenyne dan Farocaulerpin Pada Alga Hijau (Caulerpa racemosa) dari Manggewa Pulau Mansinam Manokwari dengan Pendekatan Uji In Silico Rumayomi, Esterlina; Wattimury, Dougklas; Hutasoit, Hostalige
Agritechnology Vol 7 No 2 (2024): Volume 7 Nomor 2 (Desember) 2024
Publisher : Fakultas Teknologi Pertanian, Universitas Papua, Manokwari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51310/agritechnology.v7i2.129

In some Asian cultures, C. racemosa is utilized through Traditional Medicine where it is used as a source of nutrition and is thought to have health benefits, including antioxidant and anti-inflammatory properties. One of them is treating digestive problems, which is carried out by several traditional medicine practices using C. racemosa to help overcome digestive problems or to improve intestinal health because of its fiber content. The bioactive compounds in Caulerpa racemosa play an important role, one of which is the compounds Caulersin, Caulerpol, Farocaulerpol and Caulerpenyne which are a group of compounds known as glucosinolates, which have various biological activities including the potential for health. This research method was carried out in an exploratory descriptive manner using an online database with the Windows 10 system, namely SwissADME, PubChem and PASSonline. The ingredients consist of 4 structures of C.racemosa bioactive compounds, namely: Caulersin, Caulerpol Farocaulerpol and Caulerpenyne which were obtained from the PubChem database. Based on research results, it shows that the bioactive compounds Caulersin and Caulerpol have the ability to act as hydrogen bond donors and acceptors, which shows that they are more polar and soluble in water, this has the potential to increase interactions with other molecules or proteins which can influence biological activity. Meanwhile, the absorption (GI Absorption) is only found in the compounds Caulersin, Caulerpol and Farocaulerpine, showing high absorption ability so that it can be absorbed well into the blood circulation after consumption. Overall compounds 1,2 and 3 showed good potential in terms of absorption, solubility and biological interactions. Meanwhile, the Caulerpenyne compound requires further research to understand its properties and capabilities.

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