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All Journal Jurnal Ilmu-Ilmu Perairan dan Perikanan Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Prosiding Seminar Biologi Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung The Journal of Experimental Life Sciences (JELS) Jurnal Pembangunan dan Alam Lestari Proceeding International Conference on Global Resource Conservation AGRIVITA, Journal of Agricultural Science Jurnal Pendidikan Biologi Indonesia Universa Medicina Jurnal Penelitian Pendidikan IPA (JPPIPA) Biosaintifika: Journal of Biology & Biology Education Journal of Research in Instructional Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Jurnal Kedokteran Hewan Indonesian Journal of Jamu
Sutiman B. Sumitro
Brawijaya University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Veterinary Other

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Assessment of microarchitecture and crystal structure of hydroxyapatite in osteoporosis Noor, Zairin; Sumitro, Sutiman B; Hidayat, Mohammad; Rahim, Agus Hadian; Taufiq, Ahmad
Universa Medicina Vol 30, No 1 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.29-35

Abstract

Osteoporosis is characterized by lower bone mineral density (BMD) and microarchitectural degeneration, which tends to increase bone fragility and fracture risk. Bone microstructure depends on interactions between the mineral atoms, which may perform substitution or incorporation into bone crystals, and may dynamically take over the function of calcium or may become a complementary part. The mineral atoms may also become a composite in the hydroxyapatite crystals. The aim of this study was to find an association between the bone microstructure and hydoxyapatite crystal structure in osteoporosis, in comparison to normal bone. The subjects of this study were surgery patients at the Department of Orthopedics of Ulin General Hospital in Banjarmasin and other centers. Inclusion criteria consisted of the presence of fracture of trabecular bone, normal or osteoporotic BMD values, and no past history of chronic disease. Bone was obtained from fracture patients during surgery. The characteristics of the hydroxyapatite crystals were analyzed by X-ray diffraction (XRD) and the microarchitecture by scanning electron microscopy (SEM). SEM showed degeneration of the microarchitecture of osteoporotic bone, in comparison with normal bone. On XRD there was a peak of hydoxyapatite crystals only and no other crystal phases. Diffraction patterns showed a larger crystal size in osteoporotic bone as compared to normal bone, indicating higher porosity. It may be concluded that there is a difference in crystal size and morphologic distribution of hydoxyapatite in osteoporotic bone, determining bone microarchitecture.
Computational Study of Oxidized Linoleic Acid on Dipeptidyl Peptidase-4 Shedding Suhargo, Listijani; Sumitro, Sutiman B.; Widodo, Nashi
Proceeding International Conference on Global Resource Conservation Vol 6, No 1: Proceeding of 6th ICGRC 2015
Publisher : Proceeding International Conference on Global Resource Conservation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.209 KB)

Abstract

Dipeptidyl Peptidase-4 is a epithelial transmembrane protein of many cell type such as gastrointestinal tract, biliary tract, pancreas, kidney, thymus, uterus, prostate and capillary endothelial cell. It has a cytoplasmic domain (amino acids 1-6), transmembrane domain  (amino acid 7-28) and extracellular domain (amino acids 29-766). Dipeptidyl Peptidase-4 also found in soluble form of serum and other body fluid. Soluble DPP-4 has not a cytoplasmic domain and transmembrane domain. The level of soluble dipeptidyl peptidase-4 increased in diabetes. In diabetes, Hydrogen Peroxide as Reactive Oxygen Species (ROS) involved in transmembrane DPP-4 shedding to produce soluble DPP-4. Hydrogen peroxide can be converted into hydroxyl radicals (•OH) which are highly reactive. Hydroxyl radicals can oxidize  fatty acid such as linoleic acid which is found mainly in Low Density Lipoprotein (LDL). This study was aimed to elucidate the molecular mechanism of oxidation to shed  transmembrane DPP-4 to produce soluble DPP-4. The DPP-4 model used is DPP-4 with 10-766 amino acid derived from Uniprot and 3D Jigsaw program. Oxidized linoleic acids were derived from NCBI pubchem. DPP-4 as a receptor was docked with oxidized linoleic acids as ligand by patchdock program. And the result show that 13-HODE more easily interact acid with DPP-4than  the other oxidized linoleic. That  oxidants had the active site on DPP-4 (Threonine 36 and Alanine 37) that allow the shedding of transmembrane DPP-4 to produce soluble DPP-4. But that oxidant also interact with the other  site  of DPP-4 that may destroy the catalytic domain.Keywords: DPP-4; oxidized linoleic acid; shedding
STUDY OF INSTRUCTIONAL MODELS AND SYNTAX AS AN EFFORT FOR DEVELOPING ‘OIDDE’ INSTRUCTIONAL MODEL Hudha, Atok Miftachul; Amin, Mohamad; Bambang, Sutiman
Jurnal Pendidikan Biologi Indonesia Vol 2, No 2 (2016): JULY
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (706.329 KB) | DOI: 10.22219/jpbi.v2i2.3448

Abstract

The 21st century requires the availability of human resources with seven skills or competence (Maftuh, 2016), namely: 1) critical thinking and problem solving skills, 2) creative and innovative, 3) behave ethically, 4) flexible and quick to adapt, 5) competence in ICT and literacy, 6) interpersonal and collaborative capabilities, 7) social skills and cross-cultural interaction. One of the competence of human resources of the 21st century are behaving ethically should be established and developed through learning that includes the study of ethics because ethical behavior can not be created and owned as it is by human, but must proceed through solving problem, especially ethical dilemma solving on the ethical problems atau problematics of ethics.The fundamental problem, in order to ethical behavior competence can be achieved through learning, is the right model of learning is not found yet by teachers to implement the learning associated with ethical values as expected in character education (Hudha, et al, 2014a, 2014b, 2014c). Therefore, it needs a decent learning model (valid), practical and effective so that ethics learning, to establish a human resources behave ethically, can be met.Thus, it is necessary to study (to analyze) and modificate the steps of learning (syntax) existing learning model, in order to obtain the results of the development model of learning syntax. One model of learning that is feasible, practical, and effective question is the learning model on the analysis and modification of syntax model of social learning, syntax learning model systems behavior (Joyce and Weil, 1980, Joyce, et al, 2009) as well as syntax learning model Tri Prakoro (Akbar, 2013). The modified syntax generate learning model OIDDE which is an acronym of orientation, identify, discussion, decision, and engage in behavior. Keywords: Ethics, OIDDE Learning Model, Model Behavior Learning System-consistent, Social Learning Model, Model Learning Triprakoro, Syntax
Cigarette Smoke Induces Colorectal Carcinogenesis in Wistar Rats by Decreasing The Expression of APC, MSH2 and MLH1 Novrial, Dody; Riwanto, Ignatius; Sumitro, Sutiman Bambang; Wijaya, Indra
Biosaintifika: Journal of Biology & Biology Education Vol 9, No 1 (2017): April 2017
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v9i1.8439

Abstract

Colorectal carcinogenesis induced by cigarette smoke requires at least 30-40 years. This long time duration causes an animal research conducted becomes relevant. This research was carried out to observe colorectal carcinogenesis due to cigarette smoke exposure in Wistar Rat. The observations focused on changes in epithelial morphology and expression of APC, MSH2 and MLH1. Twenty male Wistar rats inbreed strain were randomly allocated into control group and experimental group exposure to cigarettes smoke for 14 weeks and 28 weeks sequentially. Colorectal epithelial morphology was assessed on the histopathology examination, whereas the expression of APC, MSH2 and MLH1 was assessed on aspect of immunohistochemistry. The comparative analysis between the two groups was performed using non-parametric Mann-Whitney U test. Histology of colorectal epithelium showed pattern of colitis associated cancer that was significant both in 14 weeks and 28 weeks of treatment. This research indicated negative expression of APC, MSH2 and MLH1 in the colorectal cancer that were significant at 28 weeks of exposure. This research implies that chronic exposure to cigarette smoke can induce colitis associated colorectal cancer through decreased expression of APC, MSH2 and MLH1.
RECONSIDER OUR UNDERST ANDING ON BIOLOGICAL SYSTEM (A NEW CONCEPT DRIVEN BY NANOBIOLOGY AND COMPLEXITY SCIENCE) Sumitro, Sutiman Bambang
Prosiding Seminar Biologi Vol 8, No 1 (2011): Seminar Nasional VIII Pendidikan Biologi
Publisher : Prodi Pendidikan Biologi FKIP UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4957.715 KB)

Abstract

Sistem kehidupan adalah merupakan obyek kajian yang sangat rumit, dengan demikian Biologi menjadi bidang ilmu dengan obyek penelitian paling sulit dibandingkan Kimia, Fisika dan bahkan Matematika.  Akibat dari rumitnya obyek, maka kajian di bidang Biologi dan life sciences pada umumnya, cenderung dilakukan dengan pendekatan analitik  yang  bertujuan  mengurai kerumitan sehingga memudahkan pembicaraan dalam  pengembangan  konsep dan simpulan.  Namun demikian, tetap saja kita dihadapkan pada kenyataan rumitnya sistem serta banyaknya data sehingga cenderung untuk memilih maupun memilah yang pada akhirnya melakukan penyederhanaan dan pembatasan pada hal-hal yang dianggap penting atau utama sesuai dengan kapasitas kemampuan manusiawi yang kita miliki. Aktivitas penyederhanaan  (reduksionistik)  di atas merupakan jalan mencari pengetahuan yang selama kurun waktu puluhan sampai ratusan tahun belakangan ini dianggap sebagai jalan  untuk dapat  berfikir yang dapat diandalkan untuk pengembangan ilmu-ilmu hayati.  Melalui pendekatan reduksionistik seperti tersebut ini sudah banyak pengetahuan dan rahasia sistem kehidupan diperoleh dan menjadi pengetahuan ummat berupa khasanah keilmuan. Namun demikian di sisi lain, masih sangat  banyak  pula  hal yang menjadi misteri dan  terasa  tidak akan pernah dapat dipahami  bila  dikaji dengan  cara pendekatan yang selama ini dilakukan. Dominasi jalan berfikir analitik dan reduksionistik ini menjadikan khasanah ilmu hayati bersifat parsial dan bahkan terasa hanya menjadi tumpukan  pengetahuan-pengetahuan yang sulit dirajut menjadi pengetahuan untuk memahami hakekat yang memerlukan pendekatan yang lebih komprehensif.  Kecenderungan penyerderhanaan  obyek kajian  umumnya disertai  dengan memilih bagian yang dianggap strategis dan penting.  Sebagai konsekuensinya  banyak sekali asumsi dan  sekaligus juga pengabaian fakta, Akibat dari jalan berfikir selama ini  terlihat nyata pada pada Ilmu Kedokteran ketika melakukan  upaya-upaya  mengatasi permasalahan penyakit-penyakit  yang memiliki ketidak-jelasan  antara  sebab dan akibat. Penyakit-penyakit degeneratif  maupun penyakit-penyakit kejiwaan  adalah contoh  problematika  yang dianggap  pelik  di bidang Kedokteran  yang memerlukan bahasan dengan sudut pandang baru untuk mengatatasinya. Untuk memberikan kajian yang lebih komprehensif terhadap konsep-konsep bersifat linearistik hasil pendekatan analitik-reduksionistik, maka dalam kajian Ilmu-ilmu Hayati termasuk Kedokteran perlu memanfaatan konsep-konsep Fisika Modern. Hal ini berarti  Biologi  harus  menyentuh aspek diskusi  sampai pada sistem kerja atomik maupun partikel. Dengan demikian sebuah makro molekul tidak cukup hanya didiskusikan strukturnya ataupun dibahas hanya dengan bahasa Kimia, nmaun juga harus ada bahasan tentang karakter makro molekul tersebut di aspek medan gaya energi  serta  fenomena-fenomena  gerakan sangat cepat  yang  mengabaikan asas ruang dan waktu.  Selama ini,  menurut kaidah Fisika, pendekatan  Biologi diklasifikasikan sebagai cara berfikir  Newtonian. Maksudnya,  seluruh  fakta  Biologi hanya dikembangkan dari  fenomena yang  dapat  diamati melalui  indera dan  atau dengan instrumentasi yang membantu keterbatasan indera. Basis berfikir Newtonian ini menuntut  seluruh proses hidup  perlu  digambarkan dan divisualisasikan  baik tentang  struktur, bentuk, posisi (spatial) maupun  pola dan  mengamati  kecepatan gerakannya. Ceramah kali ini  berbicara tentang pemanfaatan pandangan  Nano  Biology dalam bidang Ilmu-ilmu Hayati dengan ilustrasi kajian-kajian yang menyentuh aspek molekul dan unit penyelenggara kehidupan yang berukuran antara 1 sampai 100 nm dengan memakai konsep fisika modern. Unit-unit berukuran nano tersebut  selama ini hanya didekati melalui perspektif hukum kimia  dan Biologi  dalam  kajian-kajian Biokimia dan  Biologi Sel.    Unit-unit ini umumnya berupa makro molekul bersifat susunan komplek dari beberapa komponen monomer, mereka    bekerja sangat spesifik bahkan dianggap memiliki kecerdasan. Mereka tahu kapan,  bagaimana, dimana dan dengan siapa  mereka harus bekerja.  Namun demikian bagaimana mekanismenya, medan gaya apa yang bekerja, dan mengapa dapat tetap bekerja dengan respon sangat cepat (dalam ukuran mikro sampai piko detik) sampai saat ini tidak dibahas. Selain itu sistem kehidupan mustinya juga dipandang sebagai aliran kontinu energi dan materi yang sedang menyelenggaraan  keteraturan  tubuh yang dinamis. Dengan diasumsikan bahwa rancangan atau konsep hidup sudah ada pada molekul-molekul makro ukuran nanomener ini, maka pendekatan Fisika Modern diharapkan dapat lebih membuka tabir rahasia  atom-atom atau molekul-molekul ketika mereka  menyelenggarakan  sifat hidup.  Pemikiran baru  ini terdukung oleh perkembangan  Ilmu Komputer dan Sistem Informasi,  yang memungkinkan penerapan Complexity Science dan sedapat mungkin menghindarkan pengabaian karena semua keberadaan dianggap memiliki peranan.   Kata Kunci: Biological System, Nanobiology, Complexity Science
INTERVENSI CYTOADHERENCE SEBAGAI PELUANG UNTUK PENCEGAHAN DAN TERAPI MALARIA BERAT Simamora, Dorta; Sumitro, Sutiman B.; Fitri, Loeki Enggar
Jurnal Kedokteran Brawijaya Vol 22, No 2 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.666 KB) | DOI: 10.21776/ub.jkb.2006.022.02.3

Abstract

Abstract  In  malarial  infection,  erythrocytes  infected  wih  Plasmodium  falciparum  bind  to  endothelial  vascular  (endothelial cytoadherence). This binding is implicated in the forming of sequestre and  rosette that affects the vascular circulation, and thus injures  the capillary wall. This mechanism is important in pathogenesis of malarial due to dysfunction of several organs. There are several receptors of  cytoadherence in human e.g Thrombospondine (TSP), CD-36, ICAM-1, and ELAM-1 as well as specific ligands of the parasite  e.g  Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP-1), 220 kDa protein of Pf60, Pf332, sequestrin, Pfaldhesin and STEVOR.  PfEMP-1 has been revealed as a molecule that is responsible for pathogenesis of severe malaria. This protein can pass parasitophorous vacoular membrane (PVM) of the parasite by attaching its molecule to carry Protein Export Elemen (PEXEL) and than go to the surface of erythrocytes in combination with specific helper protein in maeurer cleft.  The intervention on cytoadherence process through blocking of specific ligand directly or blocking the translocation of this ligand to the surface of erythrocytes might be important in regulating the outcome of malarial infection.  Key words : Cytoadherence, severe malaria, intervention, adhesion molecule.
Polimorfisme Gen CYP1A1 (3801 T/C dan Ile462Val) pada Pasien Kanker Serviks Paramita, Swandari; Soewarto, Soetomo; Aris, Mohammad; Bambang, Sutiman
Jurnal Kedokteran Brawijaya Vol 26, No 1 (2010)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.783 KB) | DOI: 10.21776/ub.jkb.2010.026.01.5

Abstract

ABSTRAKKanker serviks menempati peringkat pertama kanker di Indonesia dengan faktor risiko merokok, paritas tinggi dan penggunaan kontrasepsi hormonal. Sitokrom P450 1A1 (CYP1A1) memegang peran dalam metabolism karsinogen pada kanker servik yaitu Benzo[a]pyrene dan estrogen. Tujuan penelitian ini adalah untuk mengidentifikasi frekuensi dan distribusi polimosfisme gen CYP1A1 (3801 T/C and LLe462Val) pada kanker servik. Polimorfirme gen CYP1A1 dianalisis dengan menggunakan metode PCR-RFLP. Pada polimorfisme gen CYP1A1 (3801TC) ditemukan 36.1% dengan tipe wild-types T/T, 37.9% heterozigot T/C dan 25.9% homozigot C/C. Pada polimorfisme gen CYP1A1 (Ile 462Val) didapatkan 56.9% tipe wild-types Ile/Ile, 37.9% heterozigot Ile/Val dan 5.2% homozigot Val/Val. Gambaran polimorfisme tersebut sama dengan penelitian lain di Asia.Kata Kunci:  CYP1A1 gene polymorphisms, kanker servik
Karakteristik Atom Mineral pada Osteoporosis dengan Arsitektur Porosis dan Nonporosis Noor, Zairin; Sumitro, Sutiman B.; Hidayat, Mohammad; Rahim, Agus Hadian
Majalah Kedokteran Bandung Vol 45, No 1 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (651.505 KB)

Abstract

Terdapat hasil yang bervariasi dalam peningkatan bone mineral density (BMD) akibat asupan kalsium mengindikasikan keterlibatan atom mineral lain dalam perkembangan struktur tulang. Kuantitas atom mineral tulang yaitu kadar atom mineral dalam struktur tulang. Penelitian ini bertujuan untuk membandingkan karakteristik atom mineral pada gambaran arsitektur (scanning electron microscope/SEM) porosis dibandingkan dengan nonporosis. Sepuluh penderita osteoporosis dengan gambaran SEM porosis dan tujuh penderita gambaran SEM nonporosis terlibat dalam penelitian ini. Tulang yang diambil ketika operasi fraktur dianalisis mikrostruktur dengan SEM dan karakter atom mineral tulang dengan X-ray fluorescence (XRF). Pemeriksaan SEM dan XRF dilaksanakan di Laboratorium Fisika Universitas Negeri Malang. Penelitian dilakukan mulai Agustus 2010 sampai Januari 2011. Uji t dilakukan untuk menentukan perbedaan kadar mineral tulang. Hasil SEM menunjukkan perbedaan porositas dan integritas trabekular antara SEM porosis dan SEM nonporosis. Analisis XRF didapatkan komposisi atom yang lebih tinggi pada tulang SEM nonporosis yaitu P, S, Fe, Ni, Cr, Pb, dan Si. Sebaliknya, komposisi atom yang lebih tinggi pada tulang SEM porosis adalah Cu, Zn, Ca, dan Mo. Perbedaan komposisi atom tersebut tidak berbeda secara bermakna (p>0,05). Simpulan, perkembangan porositas pada osteoporosis tidak didasari oleh kuantitas atom mineral tulang. [MKB. 2013;45(1):23–7]Kata kunci: Arsitektur, atom mineral, komposit, osteoporosisMineral Atomic Characteristic on Porotic and Non Porotic Architecture  of OsteoporosisThere was variance result in increased bone mineral density (BMD) due to calcium intake which indicates involvement of another mineral atomic in bone structure development. Bone mineral atomic quantity is the level or concentration of mineral atomic in bone structure. Aim of this study was to compare mineral atomic characteristic in architecture (scanning electron microscope/SEM) porotic and non porotic figure. Ten osteoporosis patients with porotic SEM and seven non porotic SEM patients were involved in this study. Bone which was obtained from fracture surgery was analyzed for microstructure by SEM and for bone atomic mineral characteristic by X-ray fluorescence (XRF). Analysis of SEM and XRF were done in Physics Laboratory State University of Malang. This study was done from August 2010 to January 2011. t-test was done to analyse the difference of atomic mineral level. Scanning electron microscope result showed the difference in porosity and trabecular integrity between porotic and non porotic SEM. Analysis of XRF showed atomic composition was higher in porotic SEM such as P, S, Fe, Ni, Cr, Pb and Si. Conversely atomic composition such as Cu, Zn, Ca, and Mo, was higher in non porotic SEM. There was no significant difference between each groups (p>0.05). In conclusion, the development of porocity in osteoporosis is not depend on bone mineral atomic quantity. [MKB. 2013;45(1):23–7]Key words: Architecture, composite, mineral atomic, osteoporosis DOI: http://dx.doi.org/10.15395/mkb.v45n1.96
Bovine And Human Zona Pellucida 3 Gene Glycans Site Prediction Using In Silico Analysis Mubarakati, Nurul Jadid; Aulanni'am, Aulanni'am; Sumitro, Sutiman Bambang; Ciptadi, Gatot
Journal of Tropical Life Science Vol 4, No 3 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.04.03.08

Abstract

Zona pellucida is one of the protective layer of the egg cell and has a function as an intermediary species-specific fertilization. Glycoproteins of human and bovine zona pellucida is composed of three types, namely ZP1, ZP2 and ZP3. ZP3 gene has amino acid sequence homology with other mammals. Oligosaccharides components of the zona pellucida glycans are composed from units of asparagine residues (N -linked) and serine/threonine (O -linked). The aims of this study was to analyze the DNA sequences of human and bovine and further predicts glycans site on amino acid sequence of human and bovine ZP3. In this study, ZP3 gene fragments have been isolated from bovine and humans were analyzed in Silico. This work were conducted by comparing the data of DNA sequence from human and bovine PCR product using NCBI BLAST. The results showed that there were similarities at amino acid positions number 23-38. bZP3 sequence had three glycans site (Asn-X-Thr/Ser) and one site on hZP3 glycans. One of the sites was conserved between the two species.
Complex Compound with Transitional Metal of Akway Bark (Drimys piperita Hook f.) as Low Molecular Weight Scavenging Antioxidant: a Computational Study Hutasoit, Hostalige; Djoko, Dionysius Joseph; Sumitro, Sutiman B; Widjanarko, Simon Bambang
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.02

Abstract

Akway (Drimys piperita Hook f.) was known as an endogenous plant of Indonesia. This plant was investigated as free radical scavenger based on paramagnetic properties. This study aimed to identify the bioactive compound and the role of Fe metals ions to enhance the free radical scavenger capacity as Low molecular weight antioxidant (LWMA) of akway. This study was designed by ultra-performance liquid chromatography (UPLC) coupled with ultra-high-resolution time of flight-mass spectrometry detector (TOF-MS), docking (Pyrex and Discovery Studio 2016 Client) and pharmacokinetic properties prediction (SwissADME). UPLC-TOF-MS analysis showed that herbal akway bark has five molecular formula (C4H3N10O21-, C14H19N4O91-, C4H7N6O51-, C15H28NO31+, and C23H32NO71+). The docking was illustrated the complex binding akway formula with Fe and its role as a metal donor and metal acceptor. It also confirmed on pharmacokinetics properties prediction which molecular compounds of akway have aqueous solubility. It meant the herbal akway bark complexed to Fe could be a low molecular weight antioxidant and it could be escalated free radical scavenger capacity.
Co-Authors a, Aulanni'am A, Aulanniam A.A. Ketut Agung Cahyawan W Agus Hadian Rahim Ahmad Taufiq Amiruddin A Amiruddin Amiruddin Anis Artiyani Aristyani, Sherry Arman Sayuti Arman Sayuti Asri Pudjirahaju Atok Miftachul Hudha Aulanni'am, Aulanni'am Basuki B. Purnomo Basuki B. Purnomo Bayyinatul Muchtaromah Chomsa Dintasari Umi Baszary Dina Maulina Djoa, Dominikus Djago Djoko W. Soeatmadji Djoko, Dionysius Joseph Dody Novrial, Dody Dorta Simamora Dwinna Aliza Dwinna Aliza Edi Widjajanto Erdiansyah Rahmi Erdiansyah Rahmi Fatchiyah Fatah Fatchur Rohman Gatot Ciptadi Hutasoit, Hostalige Ibrohim Ibrohim Ignatius Riwanto, Ignatius Iwan Iwan Iwan Lalu A. Zaenuri Lestari, Sri Rarayu Listijani Suhargo, Listijani Loeki Enggar Fitri M. Aris A. Widodo M. Aris Widodo M. Aris Widodo M. Irsyad Nur Moch Sasmito Djati Mohamad Amin Mohammad Aris Mohammad Hidayat Muhammad Aris Widodo Muhammad Hambal Muhammad Hambal Mulyadi Adam Mulyadi Adam, Mulyadi Muslim Akmal Muslim Akmal Nashi Widodo Nur Hidayat Nurul Jadid Mubarokati Radita Intan Aisyah Pratiwi Rustidja , Sembiring, Rinawati SIMON BAMBANG WIDJANARKO Soetomo Soewarto Sri Rahayu Lestari Sri Wahjuningsih Sri Wahyuningsih Sri Widyarti Suhartojo Hardjopranjoto, Suhartojo Swandari Paramita Syafruddin s Syafruddin S T. Armansyah T. Armansyah Tongku Nizwan Siregar Warsito Warsito Zairin Noor