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All Journal Jurnal Kedokteran Brawijaya Sumatera Medical Journal
Ana Fresia
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Immunology & microbiology Medicine & Pharmacology

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 1 
The Risk of Albuminuria to The Ischemic Acute Patient With or Without Metabolic Syndrome Ana Fresia; Yuneldi Anwar
Sumatera Medical Journal Vol. 2 No. 3 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v2i3.1243

Abstract

Stroke is not only a major cause of death, but also a leading cause of disability worldwide. Metabolic syndrome is one of the predictor of stroke since it has been linked to the development of atherosclerosis that will lead to cerebrovascular event. Albuminuria is known to be an indicator of endothelial dysfunction that is a major cause of cerebrovascular disease. In this study, 50 subjects of acute ischemic stroke consist of 25 subjects of acute ischemic stroke with metabolic syndrome and 25 subjects of acute ischemic stroke without metabolic syndrome. The ischemic stroke with metabolic syndrome population is significantly associated with increased risk of albuminuria 16 times higher than the ischemic stroke without metabolic syndrome (OR = 16, IK95% 1.855 – 137.97, p=0.002).Subjects of ischemic stroke with metabolic syndrome is significantly associated with increased risk of albuminuria.
Effect of Strobilanthes crispa (Keji Beling) Ethanol Extract (EESC) on Body Weight in High-Fat Diet-Induced Wistar Rats Suandy; Sun, Michelle Angelia; Ana Fresia
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Obesity is a growing global health concern and a major risk factor for metabolic diseases. Pharmacological therapies have limitations and adverse effects. Strobilanthes crispa has demonstrated pharmacological activities. However, its ethanol extract has not been extensively evaluated for body weight effects in high-fat diet (HFD)-induced rats. This study aimed to evaluate the effect of Strobilanthes crispa ethanol extract (EESC) on body weight in HFD-induced Wistar rats. In this pretest–posttest experimental study, following a 12-week HFD induction, rats were randomly assigned to four groups (n = 6/group): vehicle control, atorvastatin (20 mg/kg BW), EESC-400 (400 mg/kg BW), and EESC-600 (600 mg/kg BW). Treatments were administered orally for 28 days, and body weight was recorded on Days 0, 7, 14, 21, and 28. Repeated measures ANOVA revealed significant effects of time (F = 28.316, p < 0.001, partial η² = 0.586) and time × group interaction (F = 17.163, p < 0.001, partial η² = 0.720), whereas the main effect of group was not significant (F = 1.983, p = 0.149). The greatest mean reduction in Δ body weight was observed in the EESC-400 group (−8.33 g), followed by the EESC-600 group (−6.67 g). The Kruskal–Wallis test demonstrated significant differences in Δ body weight among the experimental groups (H = 16.187, p = 0.001). Bonferroni-adjusted pairwise comparisons revealed significant differences between the vehicle group and the EESC-400 (p = 0.002) and EESC-600 (p = 0.006) groups. In conclusion, EESC may reduce body weight in HFD-induced Wistar rats.
Effect of Strobilanthes crispa (Keji Beling) Ethanol Extract (EESC) on Body Weight in High-Fat Diet-Induced Wistar Rats Suandy; Sun, Michelle Angelia; Ana Fresia
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.02.4

Abstract

Obesity is a growing global health concern and a major risk factor for metabolic diseases. Pharmacological therapies have limitations and adverse effects. Strobilanthes crispa has demonstrated pharmacological activities. However, its ethanol extract has not been extensively evaluated for body weight effects in high-fat diet (HFD)-induced rats. This study aimed to evaluate the effect of Strobilanthes crispa ethanol extract (EESC) on body weight in HFD-induced Wistar rats. In this pretest–posttest experimental study, following a 12-week HFD induction, rats were randomly assigned to four groups (n = 6/group): vehicle control, atorvastatin (20 mg/kg BW), EESC-400 (400 mg/kg BW), and EESC-600 (600 mg/kg BW). Treatments were administered orally for 28 days, and body weight was recorded on Days 0, 7, 14, 21, and 28. Repeated measures ANOVA revealed significant effects of time (F = 28.316, p < 0.001, partial η² = 0.586) and time × group interaction (F = 17.163, p < 0.001, partial η² = 0.720), whereas the main effect of group was not significant (F = 1.983, p = 0.149). The greatest mean reduction in Δ body weight was observed in the EESC-400 group (−8.33 g), followed by the EESC-600 group (−6.67 g). The Kruskal–Wallis test demonstrated significant differences in Δ body weight among the experimental groups (H = 16.187, p = 0.001). Bonferroni-adjusted pairwise comparisons revealed significant differences between the vehicle group and the EESC-400 (p = 0.002) and EESC-600 (p = 0.006) groups. In conclusion, EESC may reduce body weight in HFD-induced Wistar rats.
Co-Authors Suandy Sun, Michelle Angelia Yuneldi Anwar