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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Sumatera Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Yuneldi Anwar
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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The Risk of Albuminuria to The Ischemic Acute Patient With or Without Metabolic Syndrome Ana Fresia; Yuneldi Anwar
Sumatera Medical Journal Vol. 2 No. 3 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v2i3.1243

Abstract

Stroke is not only a major cause of death, but also a leading cause of disability worldwide. Metabolic syndrome is one of the predictor of stroke since it has been linked to the development of atherosclerosis that will lead to cerebrovascular event. Albuminuria is known to be an indicator of endothelial dysfunction that is a major cause of cerebrovascular disease. In this study, 50 subjects of acute ischemic stroke consist of 25 subjects of acute ischemic stroke with metabolic syndrome and 25 subjects of acute ischemic stroke without metabolic syndrome. The ischemic stroke with metabolic syndrome population is significantly associated with increased risk of albuminuria 16 times higher than the ischemic stroke without metabolic syndrome (OR = 16, IK95% 1.855 – 137.97, p=0.002).Subjects of ischemic stroke with metabolic syndrome is significantly associated with increased risk of albuminuria.
FIBRINOGEN DAN TRANSCRANIAL DOPPLER DI STROK ISKEMIK AKUT (Fibrinogen and Transcranial Doppler in Acute Ischemic Stroke) Hafizah Soraya Dalimunthe; Adi Koesoema Aman; Yuneldi Anwar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1281

Abstract

Elevated fibrinogen levels is related to the blood hyperviscosity, that causes low blood velocity. Non-contrast-enhanced transcranialDoppler (TCD) is used to evaluate blood flow from the cerebrovascular system. To know the relationship between fibrinogen levels andexamination of TCD in acute ischemic stroke through evaluation. A cross sectional study was admitted from July 2012-Juny 2013.The researchers determined the differences between fibrinogen and TCD in the stroke group and control. The researchers examinedthe relationship between fibrinogen and TCD examination in the stroke group. The fibrinogenwas measured with Clauss method. TheTCD was examined due to middle of the cerebral artery (MCA) and the Internal Carotid one Artery (ICA). The patients were diagnosedas ischemic stroke from head CT-scan. Statistical analyses employed the Independent T test, Anova test and Pearson correlation. Theresearchers had 24 patients and 24 controls that the Fibrinogen levels in stroke group is 549.16±104.84 mg/mL and in the control groupis 385.64±16.80 mg/mL. The researchers examined MCA in the stroke as well as the control and found the mean velocity 43.12±21.03and 56.97±6.22 (p=0.05), the peak velocity 74.17±32.58 and 94.55±14.11 (p=0.05) end diastolic velocity 23.27±12.66 and35.30±7.34 (p=0.00). In ICA, the stroke group and control and found the mean velocity 31.40±8.86 and 43.07±8.06 (p=0.00), thepeak velocity 54.99±11.50 and 75.04±16.04 (p=0.00) end diastolic velocity 18.23±7.67 and 25.64±5.24 (p=0.00). The correlationbetween fibrinogen and TCD in the stroke group was not significant on MCA and ICA, P>0.05. It can be concluded that the differencesbetween fibrinogen levels and TCD in the stroke group and control are significant. But there is no correlation between the fibrinogenand TCD in the stroke group.
Hubungan kadar leptin plasma, lipid plasma, dan waist to hip ratio dengan kejadian stroke Suherman A. Tambunan; Yuneldi Anwar; Hasan Sjahrir
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 2 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background : Stroke constitutes a national health problem with many risk factor. Leptin, produced by adipocyte was shown to be important risk factor for stroke. The circulating lipids and lipoproteins plays an important etiologic role in stroke. Waist to hip ratio (WHR) has been shown to be predictor of stroke. The purpose of this study is to investigate the correlation between plasma leptin, plasma lipid and WHR with stroke.Methods : A cross-sectional study performed in stroke and non stroke matched patients in Adam Malik General Hospital from March until June 2012. Concentration of plasma leptin, plasma lipid and WHR was examined and then performed a statistical analyzed.Results : From 62 subjects with stroke and non stroke have a significant correlation between plasma leptin with stroke in female group (p=0.036), but not in male (p=0.454), a significant correlation between HDL (p=0.000) and triglyceride (p=0.000) with stroke, no significant correlation between WHR and stroke in male (p=0.776), significant correlation between waist circumferences (p=0.005) and hip circumferences (p=0.002) with stroke in male. There was moderate correlation between plasma leptin and total cholesterol in stroke (r=0.413), weak correlation between plasma leptin and LDL in stroke (r=0.392), moderate correlation between plasma leptin and waist circumferences in stroke (r=0.505), strong correlation between plasma leptin and hip circumferences in stroke (r=0.624). No significant correlation between plasma leptin (p= 0.937), plasma lipid and WHR in stroke Conclusion : There was significant correlation between plasma leptin and stroke in female group, significant correlation between HDL and triglyceride with stroke, significant correlation between total cholesterol and LDL with plasma leptin in stroke. Keywords : stroke; plasma leptin; plasma lipid; WHR.
Hubungan terapi manitol 20% dengan fungsi ginjal pada penderita stroke perdarahan intraserebral dengan peningkatan tekanan intrakranial Anyta Prisca Dormida; Yuneldi Anwar; Puji Pinta O. Sinurat
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background : Intracerebral hemorrhage can increase intracranial pressure. Treatment of increased ICP is one of the most important and most common problems. Mannitol has been seen as one of the first choices in the immediate-treatment of increased ICP. The most common complications of mannitol therapy are fluid and electrolyte imbalances, hypersensitivity reactions and might also cause renal failure even in therapeutic doses. However the influence of osmotherapy on renal function in patients treated with mannitol due to increased intracranial pressure was not so far well described.Method : This was a cross sectional study of 39 subjects in Haji Adam Malik General Hospital. Subjects were patients who diagnosed with stroke caused by intracerebral hemorrhage with increasing of intracranial pressure based on neurological examination and head CT scan examination and treated with mannitol 20% dose 0.5 g/kg body weight for 3 days. Renal function were measured before and after mannitol 20% administration.Results : Of 39 patients (21 males, 18 females), mannitol 20% administration showed changes of renal function parameter on the 3rd day. There were increasing of serum creatinine level 0.21 (SD 0.51) mg% (p=0.014), increasing of serum ureum level 18.44 (SD 25.7) mg% (p=0.000), increasing of serum osmolality 8.64 (SD 17.95) mmol/kgH2O (p=0.005) and decreasing of serum sodium level 3.03 (SD 6.68) mEq/L (p=0.007). Increasing of serum potassium level and decreasing of serum chloride level were also found (p>0.05). None of patients developed anuria or oliguria. There was decreasing of GFR 14.87 (SD 36.42) mL/menit (p=0.015), but none of patients developed acute renal failure. There was a significant relationship between creatinine level and serum osmolality on the 3rd day (r=0.415, p=0.009).Conclusion : Mannitol 20% administration for stroke caused by intracerebral hemorrhage with increasing of intracranial pressure showed changes of serum creatinine, ureum, osmolality and natrium level significantly (p<0.05) and also decreased of glomerular filtration rate (p<0.05).Keywords : mannitol 20%; renal function; stroke caused by intracerebral hemorrhage; intracranial pressure
Hubungan antara kadar lipoprotein dengan kejadian stroke dan tumor otak Cut Diana Maya Theresa; Yuneldi Anwar; Alfansuri Kadri
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.258 KB)

Abstract

Background : Recent evidences showed correlation main class of lipoprotein with stroke and brain tumor. Stroke and brain tumor can caused by multifactor, and nutrition is one of their etiology.Objectives : This study aimed to investigate correlation between lipoprotein with stroke and brain tumor.Methods : This was a cross-sectional study, subjects with stroke (26 persons) and brain tumor (26 persons). All patients underwent physical and neurological examinations, neuroimaging and lipoprotein serum examinations. Results : Stroke subjects consisted of 17 (65.4%) women and 9 (34.6%) men, with mean age ±54.38 years. Mean HDL level was 38.96±15.66 mg/dL, mean LDL level was 131.69±32.37 mg/dL, mean VLDL level was 22.42±6.64 mg/dL. The LDL level were significantly correlated with stroke and had a moderate correlation (r=0.426, p=0.030). The HDL level were not significantly correlated with stroke and had a very weak correlation (r=-0.010, p=0.960). VLDL level were not significantly correlated with stroke and had a very weak correlation (r=-0.087, p=0.672). Brain tumor subjects consisted of 16 (61.5%) men and 10 (38.5%) women, with mean age ±46.46 years. Mean HDL level was 38.58±12.73 mg/dL, mean LDL level was 131.42±43.67 mg/dL, mean HDL level was 26.70±10.75 mg/dL. The LDL level were not significantly correlated with brain tumor and had a very weak correlation (r=-0.103, p=0.618). HDL level were not significantly correlated with brain tumor and had a very weak correlation (r=0.087, p=0.672). VLDL level were not significantly correlated with brain tumor and had a very weak correlation (r=0.031, p=0.881).Conclusion : There was a significant correlation between LDL level and stroke, but no significant corelation between HDL levels with stroke and VLDL levels with stroke . The HDL, LDL and VLDL levels were not significant corelation with brain tumor. Keywords : lipoprotein, HDL, LDL, VLDL, stroke,brain tumor
Hubungan penggunaan nasogastric tube dengan kejadian pneumonia pada pasien stroke akut dengan disfagia Eva Rahmi Halim; Yuneldi Anwar; Puji Pinta O. Sinurat
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background : Aspiration pneumonia is the most important acute complication of stroke related dysphagia. Tube feeding is usually recommended as an effective and safe way to supply nutrition in stroke patients with dysphagia. On the cointains, many patients on continued to aspirate eventhough the used the nasogastric tube.The purpose of this study was to confirm that there werethe is correlation between nasogastric tube usege and incidence of pneumonia in acute stroke patient with dysphagia. Methods : This cross sectional study observed 60 acute stroke patients with dysphagia consist, 30 patiens using tube feeding and 30 were not using tube feeding, who stayed in Adam Malik General Hospital. Patients who admitted with pneumonia or other pulmonary infection or decreased level of conciussness were excluded. Patients were follow up in acute phase and pneumonia was diagnosed based on Center for Disease Control Criteria that were adopted by Indonesia Association of Lung Doctors.Results : In 30 acute stroke group patients with dysphagia who used nasogastric tube mean age is of 59 years old, 13(43.3%) females and 17(56.7%) males. While the other group who not do use nasogastric tube tube feeding were 30 acute stroke patients the mean age of 54 years old, 16(53.3%) males and 14(46.7%) females. There was no significant association with very weak correlation between Nasogastric tube usedwith pneumonia ( p=0591, r=0.063).Conclusion: Nasogastric Tube using does not have a significant with very weak correlation to the occurance of pneumonia. Keywords : nasogastric tube; pneumonia; dysphagia
Co-Authors Adi Koesoema Aman Ana Fresia Anyta Prisca Dormida Cut Diana Maya Theresa Eva Rahmi Halim Hafizah Soraya Dalimunthe Hasan Sjahrir Kadri, Alfansuri Puji Pinta O. Sinurat Suherman A. Tambunan