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All Journal AcTion: Aceh Nutrition Journal Narra J Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Trends in Infection and Global Health
Setiani, Lily
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Analisis Perbedaan Angka Kesintasan pada Pasien Karsinoma Laring Yang Menjalani Total Laringektomi Dengan Dan Tanpa Diseksi Leher Fadhlia; Kurnia , Benny; Setiani, Lily; Fitria, Sova; Denantika, Oktaria; Suhanda, Rachmad
Journal of Medical Science Vol 6 No 1 (2025): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55572/jms.v6i1.117

Abstract

Pilihan terapi untuk karsinoma laring yang progresif (T3-T4) adalah operasi, baik untuk tumor laring maupun diseksi nodul pada leher, yang setelah itu dilanjutkan dengan kemoterapi, radiasi atau kombinasi kemoradiasi. Diseksi nodul pada leher dilakukan sesuai stadium penyakit. Sebagian besar pasien yang terdiagnosis pada stadium lanjut atau metastasis nodal regional, umumnya memiliki tingkat kelangsungan hidup 50%. Penelitian ini bertujuan menganalisis perbedaan angka kesintasan pasien dengan karsinoma laring yang telah menjalani total laringektomi dengan atau tanpa diseksi leher. Pengumpulan data menggunakan rekam medis pasien yang berobat ke Departemen THT-BKL RSUD dr. Zainoel Abidin sejak 1 Juli–30 September 2022. Metode penelitian berupa analitik observasional retrospektif dengan desain khusus analisis kesintasan, Diperoleh total 36 subjek, seluruhnya laki-laki, terbanyak (47,2%) pada kelompok usia 56-65 tahun. Mayoritas subjek (97,2%) memiliki riwayat merokok lebih dari 30 tahun, dengan 44,4% lokasi tumor berada di transglotis, dan pasien terbanyak (88,9%) datang ke rumah sakit pada stadium IV, secara histopatologi 75% jenis keratinizing squamous cell carsinoma. Sejumlah 41,7% menjalani total laringektomi saja dan 58,3% menjalani total laringektomi disertai diseksi leher. Hasil analisis kurva Kaplan Meier didapatkan angka bertahan hidup pada total laringektomi rata-rata 33,24 bulan dan 34,29 bulan pada total laringektomi dengan diseksi leher. Penelitian menunjukkan tidak terdapat perbedaan signifikan pada angka kesintasan pasien karsinoma laring yang menjalani total laringektomi dengan dan tanpa diseksi leher.
Management of fibrosarcoma soft palate: A rare case report Sinaga, Jakaria; Kurnia, Benny; Setiani, Lily
Trends in Infection and Global Health Vol 4, No 1 (2024): June 2024
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v4i1.38287

Abstract

Soft palate tumors can be categorized as benign or malignant, with malignant tumors being more common than benign ones. Up to 55% of intraoral tumors are found on the palate; thus, they are known as palatal tumors. Many causative or supporting factors may contribute to the development of palatal tumors, such as the long-term use of tobacco and alcohol. A final diagnosis of a palatal tumor is typically achieved through histological examination. This paper aims to present a case involving a patient diagnosed with palatal fibrosarcoma. The patient, a 39-year-old woman, was diagnosed with palatal fibrosarcoma and underwent treatment consisting of Mass Extirpation and Palatoplasty. Relevant evidence and literature were gathered through searches conducted on PubMed, Medline, and manual research. In this specific case, the surgical approach to excise the palatal tumor was determined based on factors such as its size and location. The diagnosis is based on a combination of the patient's medical history, physical examination, and further clinical assessment. Treatment for palatal tumors primarily involves surgery aimedat completely removing the tumor tissue.
Beetroot (Beta vulgaris L.) juice supplementation and hemoglobin response in head and neck cancer patients after chemotherapy Andini, Dena Tria; Kurnia, Benny; Setiani, Lily; Ridwan, Azwar; Haroen, Elvia
AcTion: Aceh Nutrition Journal Vol 10, No 4 (2025): December
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i4.2701

Abstract

Anemia frequently occurs in patients with cancer and can worsen due to chemotherapy. The literature on non-pharmacological interventions to increase hemoglobin levels in patients with head and neck cancer following chemotherapy remains limited. This study aimed to measure the effect of beetroot juice supplementation on changes in hemoglobin levels in patients with head and neck cancer who had undergone chemotherapy. Methods: An experimental study with a one-group pretest–posttest design was conducted at dr. Zainoel Abidin General Hospital, Banda Aceh (July–November 2024). The sample consisted of all head and neck cancer patients undergoing chemotherapy cycles I–VI (total sampling, n=40), divided into two treatment groups: 100 g beetroot juice (n=20) and 200 g beetroot juice (n = 20). Hemoglobin levels were measured before and 14 days after the intervention. The analysis was performed using paired t-tests and effect sizes (Cohen’s d). Results: Administration of 100 g of beetroot juice did not significantly alter hemoglobin levels, with an average difference of −0.24 g/dL (p = 0.241). In contrast, the 200-gram dose resulted in a significant increase in hemoglobin levels, with an average difference of +0.44 g/dL (p = 0.016) after 14 days of intervention. Furthermore, the estimated Cohen’s d (pooled SD) was 0.51, indicating a moderate effect. In conclusion, the administration of 200 g beetroot juice for 14 days was associated with a small but statistically significant increase in hemoglobin levels in patients with head and neck cancer who underwent chemotherapy. Further studies in the form of RCTs with larger sample sizes and stricter compliance monitoring are needed to confirm these findings and assess their clinical relevance.
Chronic tonsillitis and its potential alternative treatment: Exploration of the antibacterial activity of ethanolic Mentha piperita leaf extract against bacterial isolates from patients Munirwan, Puti G.; Setiani, Lily; Kurnia, Benny; Rahmawati, Novina; Ridwan, Azwar
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3064

Abstract

Chronic tonsillitis is commonly associated with persistent bacterial infection, predominantly involving Gram-positive organisms, and increasing antimicrobial resistance has encouraged exploration of alternative therapeutic agents derived from medicinal plants. Mint leaves (Mentha piperita) are known to contain bioactive compounds with potential antibacterial activity; however, their antibacterial efficacy against isolates specifically obtained from patients with chronic tonsillitis has not been clearly established. The aim of this study was to evaluate the antibacterial activity of ethanolic M. piperita leaf extract against bacterial isolates from patients with chronic tonsillitis. An experimental laboratory study was conducted using bacterial isolates from tonsillar core specimens. Antibacterial activity was assessed using the disk diffusion method at various extract concentrations, followed by determination of the minimum inhibitory concentration (MIC) by the microdilution method and the minimum bactericidal concentration (MBC) by subculture on plate count agar. Results showed that Gram-positive bacteria were the predominant isolates, with Staphylococcus aureus identified as the most frequent species, followed by Streptococcus agalactiae and Pseudomonas aeruginosa. The extract demonstrated greater inhibitory activity against Gram-positive bacteria, with the largest inhibition zone observed in Streptococcus agalactiae at 50% concentration (18.31 mm). In the microdilution assay, the lowest tested concentration (0.75%) inhibited bacterial growth in all tested species, and no colony growth was observed upon subculture, indicating bactericidal activity at this concentration. These findings suggest that ethanolic M. piperita leaf extract exhibits antibacterial activity, particularly against Gram-positive pathogens associated with chronic tonsillitis, and may represent a potential natural antimicrobial agent for further investigation.
Adenotonsilektomi pada Anak dengan Obstructive Sleep Apnea Berat yang disertai Obesitas Grade 2 : Tantangan Perioperatif dan Pendekatan Multidisiplin Miranda Fitri, Eva; Mondana, Wira; Cynthia Walter, Beatrice; Setiani, Lily; Natasya Br. Batu Bara, Audita
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 5 No. 2 (2026): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - April 2026
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jkkmm.v5i2.26555

Abstract

Hipertrofi adenotonsilar merupakan penyebab tersering Obstructive Sleep Apnea (OSA) pada anak, sementara obesitas berperan sebagai komorbid penting yang dapat meningkatkan derajat keparahan penyakit, risiko perioperatif, serta kemungkinan terjadinya OSA residual pascaoperasi. OSA pada anak berdampak signifikan terhadap kualitas tidur, fungsi kognitif, dan prestasi belajar, serta dapat meningkatkan morbiditas bila tidak ditangani secara adekuat. Adenotonsilektomi merupakan terapi lini pertama pada OSA pediatrik, namun pada pasien dengan obesitas diperlukan penilaian komprehensif dan modifikasi gaya hidup untuk mengoptimalkan hasil klinis. Tujuannya untuk mengetahui penilaian klinis OSA pada anak serta risiko komplikasi selama dan setelah tindakan adenotonsilektomi pada pasien OSA dengan komorbid obesitas. Kasus dilaporkan seorang anak perempuan berusia 8 tahun dengan OSA akibat hipertrofi adenotonsilar dan obesitas grade 2. Diagnosis ditegakkan berdasarkan anamnesis dan pemeriksaan fisik. Pasien menjalani tindakan adenotonsilektomi dengan anestesi umum, disertai pengaturan nutrisi untuk mencegah terjadinya OSA residual. Hasil yang didapatkan selama dan setelah tindakan tidak dijumpai komplikasi pernapasan maupun perdarahan. Nyeri pascaoperasi tergolong ringan dengan nilai Numeric Rating Scale (NRS) sebesar 2. Gejala OSA menunjukkan perbaikan yang bermakna setelah tindakan. Kesimpulannya Adalah denotonsilektomi merupakan tindakan yang aman dan efektif pada OSA pediatrik dengan obesitas apabila didukung oleh penilaian risiko perioperatif yang cermat dan pendekatan multidisiplin. Intervensi nutrisi sejak dini berperan penting dalam mencegah OSA residual dan meningkatkan luaran klinis.
Co-Authors Andini, Dena Tria Cynthia Walter, Beatrice Fadhlia Fitria, Sova Haroen, Elvia Kurnia , Benny Kurnia, Benny Miranda Fitri, Eva Mondana, Wira Munirwan, Puti G. Natasya Br. Batu Bara, Audita Oktaria Denantika Rachmad Suhanda Rahmawati, Novina Ridwan, Azwar Sinaga, Jakaria