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KARAKTERISTIK FISIK DAN INDEKS IRITASI PADA SEDIAAN SHOOTING GEL KOMBINASI LIDAH BUAYADAN BUAH ANGGUR Suharsanti, Ririn; Ariyani, Lilies Wahyu
Media Farmasi Indonesia Vol. 13 No. 1 (2018): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (353.056 KB)

Abstract

ABSTRACT Shooting gel is one of cosmetic preparations that work to overcome dry skin. High active ingredients in shooting gel are considered able to rehydrate the skin, especially dry skin. In this research will be formulated shooting gel preparation with active ingredients ofAloe vera and grapes. The famous Aloe vera helps to moisturize the skin while the grapes also contain active compounds that are efficacious as antioxidants that are good for the skin. Therefore, the combination of these two active ingredients should be developed on the shooting gel preparation. This study aims to see the spread, stickiness, pH, viscosity, irritation of shooting gel with variations of concentration of active ingredients of Aloe vera and grapes. This research was started with formulation of shooting gel preparation with combination concentration of active ingredient 80% (FI); 85% (FII); 90% (FIII). Shooting gel is evaluated physical characteristics with parameters spreadibility, adhesivity,viscosity and pH. It was also evaluated the irritation index of the skin using male rats. The data obtained were analyzed with different 95% confidence level test to know the existence of significant difference between treatment groups. The experimental results of shooting gel physical characteristics showed that the concentration variation did not affect the adhesivity (p> 0.05) but affects pH, viscosity and spreadibility (p <0.05). Shooting gel with all three concentrations did not irritate the skin of male rats.
FORMULASI SEDIAAN NANOGEL MINYAK ZAITUN SEBAGAI ANTIACNE Ariyani, Lilies Wahyu; Wulandari, Wulandari
CENDEKIA EKSAKTA Vol. 5 No. 2 (2020)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.3194/ce.v5i2.3737

Abstract

Minyak zaitun mengandung polifenol yang ada dalam buah zaitun, air limbah minyak zaitun, dan daun zaitun memiliki aktivitas antimikroba terhadap mikroorganisme spektrum luas. Staphylococcus aureusmerupakan salah satu penyebab terjadinya jerawat. Upaya untuk mengatasi jerawat salah satunya dengan membuat sediaan nanogel minyak zaitun yang sekaligus untuk meningkatkan daya penetrasinya. Penelitian ini bertujuan untuk memformulasikan sediaan nanogel minyak zaitun danmengetahui karakteristik fisiknya serta mengetahui daya hambat nanogel minyak zaitun terhadap bakteri Staphylococcus aureus dengan metode sumuran. Konsentrasi minyak zaitun yang digunakan yaitu F I 2,5%, F II 5% dan F III 7,5%. Berdasarkan hasil pengujian, minyak zaitun dapat diformulasikan menjaadi sediaan nanogel dan peningkatan konsentrasi minyak zaitun dapat mempengaruhi karakteristik fisik sediaan. Formula yang memiliki karakteristik fisik dan aktivitas antibakteri Staphylococcus aureus terbaik adalah formula II dengan konsentrasi minyak zaitun 5%. Kata kunci: Antiacne, Minyak Zaitun, Nanogel, Staphylococcus aureus