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All Journal HAYATI Journal of Biosciences Journal of Food and Pharmaceutical Science Jurnal Biodjati Jurnal Wiyata : Penelitian Sains dan Kesehatan Media Farmasi Indonesia Jurnal Pengabdian Masyarakat Bangsa Journal of Health Management and Pharmacy Exploration (JOHMPE) Journal of Food and Pharmaceutical Sciences Biosaintifika: Journal of Biology & Biology Education Kunir: Jurnal Farmasi Indonesia (KJFI) Indonesian Journal of Jamu
Ririn Suharsanti, Ririn
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KADAR KURKUMIN EKSTRAK RIMPANG KUNYIT (Curcuma domestica) SECARA KLT DENSITOMETRI DENGAN PERBEDAAN METODE EKSTRAKSI Suharsanti, Ririn; Astutiningsih, Christina; Susilowati, Novy Dwi
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 7, No 2 (2020)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

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Abstract

Latar belakang: Senyawa kurkuminoid terdiri dari kurkumin, desmetoksi kurkumin dan bisdemetoksi kurkumin. Cara ekstraksi sangat mempengaruhi konsentrasi atau hilangnya efek terapi dari simplisia karena beberapa simplisia bersifat relatif stabil dan juga dapat terurai tergantung dari cara ekstraksi yang digunakan. Tujuan: Menetapkan kadar senyawa kurkumin dengan perbandingan metode ekstraksi maserasi dan sokletasi. Metode: Serbuk rimpang kunyit diekstraksi dengan 2 cara yakni maserasi dan sokletasi. Dua sampel ekstrak tersebut dianalisis kualitatif dengan KLT menggunakan fase gerak kloroform : metanol 9,5:0,5 dan dideteksi pada sinar tampak dan sinar UV. Penetapan kadar kurkumin dilakukan pada panjang gelombang 254 nm dengan KLT densitometer. Hasil: Rendmen ekstrak hasil ekstraksi maserasi adalah 16,25% dan  22,36% untuk sokletasi. Hasil skrining fitokimia kedua sampel mengandung senyawa fenolik, flavonoid dan triterpenoid. Kadar kurkumin hasil maserasi 41,11µg/ml dan sokletasi 41,33 µg/ml. Hasil uji t diperoleh signifikansi 0,445<0,05. Simpulan: Kadar kurkumin hasil sokletasi lebih banyak dibanding maserasi namun tidak terdapat perbedaan yang antara keduanya setelah di uji t.
PENGARUH GAYA HIDUP TERHADAP KENAIKAN TEKANAN DARAH DI KOTA SEMARANG Prasetyaningrum, Erna; Suharsanti, Ririn
Media Farmasi Indonesia Vol. 12 No. 1 (2017): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

ABSTRACT One of the degenerative diseases causing death was cardiovascular diseases. Hypertension is a major risk factor for cardiovascular found in 14% of the Indonesian population. Many risk factors that cause hypertension are lifestyle habits such as smoking, drinking alcohol, fatty foods. The aim of research is to know the correlation between the lifestyle of the community blood pressure rise in Semarang. Research is a non-experimental research. The variables studied are gender, age, smoking behavior, relish eating fried foods, offal, fat, drinking sodas and coffee. The research subject is Jatisari village community Mijen Subdistrict, District Limbangan boja and Muktiharjo Tlogosari Semarang. The number of subjects are 54 people, at least 20 years old. Collecting data is carried out using interview techniques and measurement of blood is performed pressure using a sphygmomanometer. Data were analyzed by descriptive analytic. The results showed that increased blood pressure in people Semarang based on gender male by 29.6%, amounting to 70.4% of women, by the age of 20-30 years was 1.8%, 30-40 th of 3.7 %, 7.5% 40-50 years old, 50-60 years old 31.5%, 60-70 years old amounted to 35.2%,> 70 th by 20.4%, amounting to 20.7% of smoking, eating fries 44.6%, eating offal of 5.4%, 11.9% fat meal, drink soft drinks by 3.3%, coffee by 20.7%, 6.5% high-salt foods. The education related to the symptoms, risk factors, treatment of hypertension and prevention of complications through printed and electronic media can prevent hypertension or other complications.
KARAKTERISTIK FISIK DAN INDEKS IRITASI PADA SEDIAAN SHOOTING GEL KOMBINASI LIDAH BUAYADAN BUAH ANGGUR Suharsanti, Ririn; Ariyani, Lilies Wahyu
Media Farmasi Indonesia Vol. 13 No. 1 (2018): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

ABSTRACT Shooting gel is one of cosmetic preparations that work to overcome dry skin. High active ingredients in shooting gel are considered able to rehydrate the skin, especially dry skin. In this research will be formulated shooting gel preparation with active ingredients ofAloe vera and grapes. The famous Aloe vera helps to moisturize the skin while the grapes also contain active compounds that are efficacious as antioxidants that are good for the skin. Therefore, the combination of these two active ingredients should be developed on the shooting gel preparation. This study aims to see the spread, stickiness, pH, viscosity, irritation of shooting gel with variations of concentration of active ingredients of Aloe vera and grapes. This research was started with formulation of shooting gel preparation with combination concentration of active ingredient 80% (FI); 85% (FII); 90% (FIII). Shooting gel is evaluated physical characteristics with parameters spreadibility, adhesivity,viscosity and pH. It was also evaluated the irritation index of the skin using male rats. The data obtained were analyzed with different 95% confidence level test to know the existence of significant difference between treatment groups. The experimental results of shooting gel physical characteristics showed that the concentration variation did not affect the adhesivity (p> 0.05) but affects pH, viscosity and spreadibility (p <0.05). Shooting gel with all three concentrations did not irritate the skin of male rats.
UJI AKTIVITAS ANTIJAMUR EKSTRAK ETANOL DAUN SOM JAWA TERHADAP PERTUMBUHAN Candida albicans UNTUK MENJAMIN MUTU PENGGUNAAN SEBAGAI OBAT HERBAL ANTIKEPUTIHAN Suharsanti, Ririn; Wibowo, F.X. Sulistyanto
Media Farmasi Indonesia Vol. 11 No. 2 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

ABSTRACT Empirically, leaves and roots of som Java (Talinum triangulare (Jacq.) Willd) has been used as a whiteness medicinal drug efficacious. This study aims to better ensure the quality of ethanolic leaf extract som Java as whiteness herbal medicine based test antifungal activity against Candida albicans growth. The method used was agar diffusion method with PDA (Potatoes Dextrose Agar) were inoculated Candida albicans, then filled with test compounds antimicrobials that are reconstituted with the solvent DMSO extract concentration, incubated for 3x24 hours at a temperature of 25°C, observations were made by measuring the inhibition zone around sinks. Antifungal activity test showed inhibition zone began to extract the solvent DMSO concentration of 40% amounting to 1.380 ± 0.028, increasing the concentration of the inhibitory zones is increasing as well. This is due to the increasing concentration, it also increase the active substance content which are within the extract that can serve as an antifungal
POTENSI TABIR SURYA SERTA KANDUNGAN FENOLIK DAN FLAVONOID TOTAL EKSTRAK ETANOL DAUN JATI CINA (Cassia Angustifolia) PADA BERBAGAI KONSENTRASI PELARUT Suharsanti, Ririn; Ariani, Lilies Wahyu
Media Farmasi Indonesia Vol. 14 No. 1 (2019): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Daun jati cina yang biasa dikenal sebagai pelangsing memiliki kandungan senyawa fenolik yang cukup tinggi. Adanya kandungan fenolik ini membuat daun jati cina menarik untuk digali lebih lanjut potensinya sebagai tabir surya. Penelitian ini bertujuan untuk membandingkan kandungan fenolik total dan flavonoid total serta potensi tabir surya dengan nilai sun protection factor (SPF), persen transmisi eritema (% Te) dan persen transmisi pigmentasi (% Tp) daun jati cina yang dimaserasi menggunakan pelarut etanol 50%, 70% dan 96%. Metode penetapan kadar fenolik total menggunakan Folin-Ciocalteu dengan standar asam galat sedangkan flavonoid total menggunakan AlCl3 dengan standar rutin. Penentuan nilai SPF, % Te dan % Tp menggunakan metode spektrofotometri Uv-Vis. Hasil pengukuran total fenolik ekuivalen asam galat dan total flavonoid ekuivalen rutin pada pelarut etanol 50%, 70% dan 96% berturut turut adalah 7,10 mg EAG (ekivalen asam galat)/g dan 65,10 mg ER (ekivalen rutin)/g; 7,96 mg EAG/g dan 23,16 mg ER/g serta 14,83 mg EAG/g dan 155,17 mg ER/g. Ekstraksi dengan pelarut etanol 96% mampu menarik senyawa fenolik dan flavonoid tertinggi dibandingkan yang lain. Nilai SPF pada pelarut etanol 50%, 70% dan 96% berturut turut adalah 17,63; 15,88 dan 23,89. Nilai % Te dan % Tp pada pelarut etanol 50%, 70% dan 96% berturut turut adalah 6,29% dan 3,64%; 9,51% dan 7,00% serta 1,91% dan 0,97%. Nilai SPF daun jati cina pada semua konsentrasi pelarut etanol memiliki kategori ultra karena berada pada nilai di atas 15 dengan nilai SPF terbaik pada ekstraksi dengan pelarut etanol 96%. Nilai hasil %Te dan %Tp ekstraksi daun jati cina dengan pelarut etanol 96% dikatakan paling baik menahan kulit untuk mencegah kemerahan (eritema) dan menahan penggelapan kulit (pigmentasi) dengan kategori ekstra proteksi.
KADAL IRAN (ETHANOL CONTENT NIRA SIWALAN (Borassus flabellifer)) WITH GC-MS (GAS CHROMATOGRAPHY MASS SPECTROMETRY) ANALYSIS Ulfa, Maria; Astuti, Retno Yuni; Alam, Rizky Bachrul; Suharsanti, Ririn
Media Farmasi Indonesia Vol. 14 No. 2 (2019): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

There are many siwalan saplings among the people who utilize various kinds of fruit,leaves, nira siwalan. However, many people like the fruit and the water. In this case, legenlontar or other names nira siwalan can produce ethanol from siwalan flowers. So that, frommany people using nira only as a drink and so far some people produce nira on a small scale.Nira is a liquid that contains certain sugar levels, namely sucrose, glucose, fructose andcarbohydrates, which have an average acidity level of 6-7 and smell nice. This study aims todetermine the amount of ethanol content contained in nira siwalan and determine the effect ofstorage time on ethanol levels in nira siwalan. Samples of nira siwalan both original andbulk were fermented for 3 days, 6 days, and 9 days and then distilled at a temperature of78.37 ° C. Determination of ethanol content in the distillate results was carried out usingGCMS (Gas Chromatography Mass Spectrometry). The results of this study are the originalethanol content of nira siwalan at storage of 3.6.9 consecutive days, namely 0.27%, 0.91%,and 1.02%. While the results of the bulk ethanol juice of the siwalan level at storage of 3,6.9days were obtained ethanol levels respectively ie 32.05%, 39.99% and 44.42%. From thisstudy it can be concluded that the ethanol content in bulk nira siwalan is more than theoriginal nira siwalan.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL, AIR BUNCIS (Phaseolus vulgaris L.) DAN FRAKSI-FRAKSINYA TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Kristianto, Yosua Bayu; Sulistyarini, Indah; Suharsanti, Ririn
Media Farmasi Indonesia Vol. 14 No. 2 (2019): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Infection is a disease caused by the entry of a pathogenic microorganism in the body'stissues. One of the bacteria that can cause infection is Staphylococcus aureus. Beans are oneof the plants that contain alkaloids, flavonoids and saponins. Which is believed to inhibit thegrowth of Staphylococcus aureus bacteria. This study aims to determine the antibacterialactivity of extracts and its fraction on the growth of Staphylococcus aureus bacteria atconcentrations of 5%, 10%, and 15%. Bean powder was remacerated with 70% ethanol for 3days, and the extract obtained was subjected to fractionation with n-hexane, ethyl acetate,and water using a separating funnel. The antibacterial activity on the extract and eachfraction was made with a concentration of 5, 10, and 15% using the agar well method.Dimethyl Sulphoxide (DMSO) as a negative control and ciprofloxacin 0.005% as a positivecontrol. Antibacterial activity was measured using the inhibition zone diameter of bacterialgrowth. The results showed that the average inhibition zone diameter of ethanol extract, nhexanefraction and ethyl acetate fraction of beans at concentration of 5%, 10% and 15%respectively were of 0.842; 0.935 and 1.042 cm. The n-hexane fraction is 0.595; 0.787; and0.947 cm. Ethyl acetate fraction of 0.926; 1,008 and 1,049 cm. Whereas the water fractiondoes not provide antibacterial activity. The contact bioautography test results showed thatalkaloid compounds, flavonoids and saponins were able to inhibit the growth ofStaphylococcus aureus bacteria. The conclusions of this study are ethanol extract, n-hexanefraction, and ethyl acetate fraction of chickpeas having antibacterial activity againstStaphylococcus aureus bacteria, but the water fraction has no antibacterial activity against S.aureus; there was a significant difference (p <0.05) between the extract, n-hexane fraction,ethyl acetate fraction and water fraction.
PERBANDINGAN KANDUNGAN FENOLIK TOTAL, FLAVONOIDTOTAL DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLDAUN JAMBU BOL (Syzigium malaccense L.) DAN DAUN JAMBU AIR KANCING (Syzigium aqueum) Zahrani Primadiastri, Ilavi; Dwi Wulansari, Endang; Suharsanti, Ririn
Media Farmasi Indonesia Vol. 16 No. 2 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.028 KB) | DOI: 10.53359/mfi.v16i2.180

Abstract

Leaves of malay apple (Syzygium malaccense L.) and water apple (Syzygium aqueum) are plants that contain phenolic and flavonoid compounds which have antioxidant activity. The aim of this study was to determine the differences in total phenolic content, total flavonoids and antioxidant activity of ethanol extract of malay apple leaves and water apple leaves. The extraction method uses maceration with 96% ethanol solvent in a ratio of 1:15. The ethanol extract of malay apple leaves and water apple was tested for total phenolic content using the Folin-Ciocalteu method, total flavonoids using the colorimetric method and antioxidant activity using the DPPH method. Qualitative identification of quercetin compounds was performed by densitometry tlc. In the phenolic and flavonoid content test, the total sample extract was made with a concentration of 5000 ppm. In the antioxidant activity test of the extract samples, a series of concentrations of 80, 100, 120, 140 and 160 ppm were made. The results showed that the total phenolic content in the ethanol extract of malay apple leaves has an average of 12.5149 mgGAE/g and water apple leaves of 14.3207 mgGAE/g. The total flavonoid content in the ethanol extract of malay apple leaves has an average of 9.1613 mgQE/g and water apple leaves of 16.5893 mgQE/g. The ethanol extract of malay apple leaves has antioxidant activity with an average IC50 of 138.3315 ppm and water apple leaves of 117.6745 ppm. In qualitative identification densitometry the Rf value of quercetin is 0,68; ethanol extract of malay apple leaves is 0,68 and water apple leaves is 0,85. The results of the independent statistical T test showed that there were differences in the total phenolic content, total flavonoids and antioxidant activity in the ethanol extract of malay apple leaves and water apple leaves.
Comparison of ethyl acetat fracination of ganitrie (Elaeocarpus sphearicus) seeds as anti bacterial of Staphylococcus aureus and determination of total flavonoid content Sari, Yunita Kurnia; Suharsanti, Ririn; Wulandari, Wulandari
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.291

Abstract

Infectious disease is a disease coused by the presence pf pathogenic microbes. Stahpylococcus aureus is a gram positive aerobic bacterium that couses phyogenic infections on humans. Antibiotics are the best choise to treat an infections. The purpose of this study was to determine the antibacterial activity of ganitri seed (Elaeocarpus sphearicus) to determine the exstract ratio, the ethyl acetat fractination of ganitri seeds woth a concetration of 35% on the growth of staphylococcus aureus bacteria and to determine the total flavonoid content. Exctraction was carried out by maceration method for 3x24 hours with 96% ethanol as solvent. Exctraction fractination using 2 methods, the first method is using 30% ethanol, cloroform, and ethyl acetat as solvent. The second fractination method uses hot destiled water and ethyl acetat as solvents. The test result of total flavonoid content in ganitri (Elaeocarpus sphearicus) seeds in ethanol exstract were 38.009 mgEQ / g, fraction 1 of 99.512 mgEQ / g, fraction 2 of 68.235 mgEQ / g. From the result of the determinatoin of the ethyl acrtat fraction 1 had highest yield with an average value of 99,512 mgEQ/g. The antibacterial activity test was 35% in each sample ang using a positive control of ciprofloxcacin and a negative control of DMSO. Based on the result of the clear zone of the ethanol extract was 1.118 cm, the ethyl acetate 1 fraction was 1.170 cm, and the ethyl acetat 2 fraction was 0,956 cm.
Antioxidant Activity and Pancreatic Lipase Inhibition of Curcuma aeruginosa Roxb Rhizome Fractions Suharsanti, Ririn; Wahyuono, Subagus; Yuniarti, Nunung; Astuti, Puji
Jurnal Biodjati Vol 9, No 2 (2024): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i2.33900

Abstract

Antiobesity with a lipase inhibitor mechanism will block the hydrolysis of triglycerides into fatty acids and glycerol, while antioxidant compounds are very useful in conditions of obesity to prevent excess damage from degenerative diseases. Curcuma aeruginosa Roxb extract has been proven to have the effect of inhibiting pancreatic lipase so further effects will be seen at the fraction level. The purpose of this research is to investigate the phytochemical components ,antioxidant activity and pancreatic lipase inhibition of Curcuma aeruginosa Roxb fractions. Ethanolic extract of the Curcuma aeruginosa Roxb rhizome was separated using the solid-liquid chromatography with 3 different solvents (n-hexane, ethyl acetate, ethanol) to give n-hexane (HF), ethyl acetate (EAF), and ethanol (EF), and the insoluble (IF) fractions. Each fraction detected phenolics, flavonoids, alkaloids, tannins, saponins, triterpenoids/steroids. EF has the highest total flavonoid and phenolic content. Antioxidant activity of all fractions were measured using DPPH reduction, ABTS, and FRAP methods. The best antioxidant activity of all fractions using the DPPH method was EF with IC50 21.93 ± 3.39µg/mL, ABTS method was HF with IC50 24.56±1,03 µg/mL and FRAP method was IF with IC50 20.79±1,03 µg/mL. Totals of phenolics and flavonoids in EF strongly support the antioxidant activity of the DPPH method. The highest inhibition of pancreatic lipase was found in EAF at 35.16±0.24 % (100 µg/ml). There was significant difference between EAF and xenical (orlistat) (p
Co-Authors Advistasari, Yustisia Dian Alam, Rizky Bachrul Ariani, Lilies Wahyu Ariyani, Lilies Wahyu Aryanti, Ninda Astuti, Retno Yuni Christina Astutiningsih Dwi WULANSARI, Endang Endang Lukitaningsih erna prasetyaningrum Faidliyah Nilna Minah Firmiaty, Sri Indah Sulistyarini Intan Martha Cahyani, Intan Martha Ismail, Wan Ismahanisa Khairunnisa, Hanifah Kristianto, Yosua Bayu Lia Kusmita Maria Ulfa Muhammad Ryan Radix Rahardhian Mutiara, Erlita Verdian Nining Sugihartini Nunung Yuniarti Nurjanah, Hidayatillah Puji Astuti Putri, Chintiana Nindya Ramonah, Dewi Ryan Radix Rahadhian, Muhammad Ryan Radix Rahardhian, Muhammad Sari, Yunita Kurnia Sri Adi Sumiwi Subagus Wahyuono Sufiyanto, Mohammad Imam Susilowati, Novy Dwi Wahyu Wulandari Wardhani, Risty Ayu Wibowo, F.X. Sulistyanto Wulandari Wulandari Yasmiwar Susilawati Zahrani Primadiastri, Ilavi