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All Journal Jurnal Surya Medika JSFK (Jurnal Sains Farmasi & Klinis)
Sapriati, Aisyah Nur
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Treatment of the cytokine storm in COVID-19: review of clinical pharmacology Sapriati, Aisyah Nur; Rahmawati, Fita; Nuryastuti, Titik
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.2.162-183.2023

Abstract

The cause of the COVID-19 pandemic can be attributed to the Acute Respiratory Syndrome Virus-2 (SARS-CoV-2). COVID-19 manifests with severe symptoms in the upper respiratory tract and can progress to a critical condition due to an acute hyperinflammatory response that triggers a cytokine storm. The cytokine storm refers to an excessive or impaired production of proinflammatory cytokines, resulting in immune dysregulation and uncontrolled inflammatory activity. To effectively address the hyperinflammatory state induced by SARS-CoV-2 infection, it is imperative to explore promising strategies aimed at overcoming the cytokine storm, such as the prompt initiation of anti-inflammatory therapy. Several classes of drugs can potentially prevent the deterioration of COVID-19 patients by mitigating immune system dysregulation and suppressing uncontrolled inflammatory responses. These drug classes encompass corticosteroids, chloroquine and hydroxychloroquine, inhibitors of interleukin-1 (IL-1), inhibitors of interleukin-6 (IL-6), inhibitors of tumor necrosis factor (TNF), and anti-inflammatory drugs. Additionally, tumor necrosis factor alpha (TNF-α) inhibitors, as well as inhibitors targeting the Janus kinase signaling pathway and activator of transcription (JAK/STAT), have exhibited efficacy in treating COVID-19. This efficacy is evident when considering the drug's mechanism of action and pharmacokinetics, while also taking into account the tolerable side effects associated with their usage
Badai Sitokin pada Covid-19: Ulasan Naratif: Cytokine Storm in Covid-19: Narative Review Sapriati, Aisyah Nur; Rahmawati, Fita; Nuryastuti, Titik
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.7243

Abstract

SARS-Cov-2 adalah virus yang dapat menyebabkan terjadinya penyakit COVID-19 yang parah yang terkait dengan peningkatan produksi sitokin/kemokin proinflamasi. Badai sitokin adalah pelepasan sitokin proinflamasi yang berlebihan atau tidak terkendali yang menyebabkan kekacauan pada sistem kekebalan tubuh dan respon inflamasi yang tidak terkendali. Artikel ini dibuat dengan tujuan untuk memberikan pemahaman terkait badai sitokin, patofisiologi yang menyertainya, manifestasi klinis, pengukuran laboratorium, dan faktor-faktor yang memicu terjadinya badai sitokin. Badai sitokin pada COVID-19 ini menyebabkan terjadinya kegagalan multi-organ bahkan kematian. Faktor-faktor yang menyebabkan terjadinya badai sitokin pada pasien COVID-19 ini bukan saja disebabkan oleh adanya SARS-CoV-2 tetapi adanya factor pendukung lain seperti usia yang lebih tua, jenis kelamin laki-laki, golongan darah A serta adanya gangguan metabolisme pada pasien seperti peningkatan tekanan darah, obesitas maupun diabetes.
Co-Authors Fita Rahmawati Titik Nuryastuti