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All Journal Oto Rhino Laryngologica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Airlangga, Tri Juda
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Sensorineural hearing loss in Bartter syndrome Zizlavsky, Semiramis; -, Fadilah; Soewento, Ronny; Airlangga, Tri Juda
Oto Rhino Laryngologica Indonesiana Vol 51, No 1 (2021): Volume 51, No. 1 January - June 2021
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v51i1.445

Abstract

Background: Bartter syndrome is a rare inherited case characterized by autosomal recessive and has few different types. Diagnosis is established by laboratory findings, namely hypokalemic metabolic alkalosis, and normotensive. Hearing loss indicates Bartter syndrome type IV. Purpose: To report a case of Bartter syndrome with delayed speech. Case report: A seven years old girl with delayed speech and recurrent hypokalemia was referred to the Otolaryngology Head and Neck Surgery Department, Dr. Cipto Mangunkusumo Hospital, in order to evaluate the hearing level and treatment needed. Based on the Otoacoustic Emission (OAE), Brainstem Evoked Response Audiometry (BERA), and Auditory State Steady Response (ASSR), the diagnosis was profound bilateral sensorineural hearing loss and proceeded with hearing aid and also speech occupational therapy. Clinical question: Is there a relationship between Bartter syndrome and the incidence of hearing loss? Review method: Literature review through PubMed, Cochrane, and EBSCO, using keywords such as the impacts of Bartter syndrome on hearing loss, and sensorineural hearing loss in Bartter syndrome case. Result: Following screening of double publication and based on clinical questions over the past five years, only one relevant literature was found. Conclusion: Audiological assessment should be done in all Bartter syndrome’s cases. Early intervention and timely audiological rehabilitation could improve the quality of life of such children.ABSTRAK Latar belakang: Sindrom Bartter merupakan kasus jarang, yang diturunkan secara autosomal resesif dan terdiri atas beberapa tipe. Diagnosis ditegakkan berdasarkan temuan laboratorium yaitu hipokalemi, alkalosis metabolik dan tekanan darah normal. Adanya gangguan pendengaran merupakan sindrom Bartter tipe IV. Tujuan: melaporkan kasus Sindrom Bartter dengan keterlambatan bicara. Kasus: Dilaporkan satu kasus anak perempuan berusia tujuh tahun dengan gangguan bicara dan terdapat riwayat hipokalemia berulang yang dirujuk ke Departemen Telinga Hidung Tenggorok-Bedah Kepala Leher, Rumah Sakit Cipto Mangunkusumo untuk menilai ambang dengar serta tatalaksana selanjutnya. Berdasarkan hasil pemeriksaan Otoacoustic Emission (OAE), Brainstem Evoked Response Audiometry (BERA) dan Auditory State Steady Response (ASSR) ditemukan tuli sensorineural sangat berat bilateral yang kemudian ditatalaksana dengan pemakaian Alat Bantu Dengar dan terapi wicara dan okupasi. Pertanyaan klinis: Apakah ada hubungan antara sindroma Bartter dengan insidens gangguan pendengaran? Telaah literatur: Pencarian literatur melalui, PubMed, Cochrane dan EBSCO dengan kata kunci hubungan gangguan pendengaran pada sindrom Bartter, gangguan pendengaran sensorineural pada sindrom Bartter. Hasil: Setelah dilakukan skrining yakni publikasi ganda dan sesuai pertanyaan klinis dari lima tahun terakhir hanya didapatkan satu literatur yang relevan. Kesimpulan: Pemeriksaan pendengaran harus dilakukan pada kasus dengan sindrom Bartter. Intervensi dini dan rehabilitasi audiologi yang tepat waktu dapat meningkatkan kualitas hidup anak dengan sindrom Bartter.Kata kunci: sindroma Bartter, tuli sensorineural.
Kajian faktor-faktor yang berhubungan dengan skor nasalance pada pasien celah palatum Yassi, Duhita; Widiarni, Dini; Airlangga, Tri Juda; Aryanti, Lestaria; Mansyur, Muchtarudin
Oto Rhino Laryngologica Indonesiana Vol. 45 No. 2 (2015): Volume 45, No. 2 July - December 2015
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v45i2.117

Abstract

Latar belakang: Celah bibir dan palatum merupakan kelainan proses pertumbuhan area orofasial yang menimbulkan permasalahan kompleks. Penelitian ini menitikberatkan permasalahanyang terkait dengan fungsi bicara. Tujuan: Penelitian ini melaporkan gambaran skor nasalance padacelah palatum, hubungan antara skor nasalance percontoh celah palatum dan tanpa celah palatum sertafaktor-faktor yang berhubungan dengan skor nasalance. Metode: Desain penelitian adalah comparativecross sectional. Pengambilan percontoh dilakukan dengan purposive sampling. Dilakukan wawancara,pengisian kuesioner, pemeriksaan THT, audiometri, timpanometri, nasoendoskopi, dan nasometri.Hasil: Didapatkan gambaran rerata skor nasalance percontoh celah palatum. Terdapat  perbedaanbermakna antara skor nasalance percontoh celah palatum dan tanpa celah palatum pada Uji Gajah danUji Hantu (p<0,001). Pada analisis multivariat secara keseluruhan faktor-faktor yang berhubungandengan skor nasalance (adenoid, otitis media efusi, serta gangguan pendengaran) dan keberadaancelah palatum berpengaruh secara signifikan terhadap skor nasalance untuk semua uji nasalance(p<0,05) pada pengujian terhadap kedua kelompok percontoh. Bila dilihat secara parsial faktor adenoidberpengaruh secara signifikan terhadap skor semua uji nasalance baik pada analisis kedua kelompokpercontoh maupun pada percontoh celah palatum saja. Kesimpulan: Rerata skor nasalance kelompokcelah palatum lebih tinggi daripada kelompok tanpa celah palatum. Didapatkan peran faktor yangberpengaruh terhadap skor nasalance, khususnya adenoid. Diperlukan penelitian lebih lanjut terhadappercontoh sesudah operasi sehingga bisa dijadikan sebagai evaluasi terhadap keberhasilan tindakan. Kata kunci: celah palatum, skor nasalance, tonsil, adenoid, otitis media efusi, gangguan pendengaran ABSTRACTBackground: Cleft lip and palate is an orofacial malformation and associated with many problems. This study concerned in speech problem in cleft palate patients. Purpose: This study reportednasalance score in cleft palate patients, the correlation between nasalance score in cleft palate and noncleft palate groups and also some factors related with nasalance score in cleft palate patients. Methods:The design of this study was comparative cross sectional, with purposive sampling. Data was collectedwith interview, questioner apllication, ENT examination, audiometry, tympanometry, nasoendoscopy,and nasometry. Results: The result of this study reported the mean of nasalance score in cleft palatepatients. There was significant difference in nasalance score between cleft palate and non cleft palatepatients in Uji Gajah and Uji Hantu (p>0,05). In multivariate analysis, in general the factors relatedwith nasalance score (adenoid, otitis media with effusion, and hearing loss) and cleft palate  itself weresignificantly correlated with nasalance score in all nasalance test (p<0,05) in both groups analysis butno signifficant correlation in cleft palate group analysis. Partially, adenoid  was significantly correlated in both group analysis and cleft palate group analysis. Conclusion: The mean of nasalance score incleft palate group was higher than non cleft group. Some factors in this study, especially adenoid had corelations with nasalance score. It needs further study to evaluate the nasalance score patients withcleft palate after surgery to compare the results. Keywords: cleft palate, nasalance score, tonsil, adenoid, otitis media with effusion, hearing disturbance
Sensorineural hearing loss in a child with congenital hypothyroidism receiving thyroid hormone replacement therapy Zizlavsky, Semiramis; Handayani, Tri; Suwento, Ronny; Safitri, Eka Dwi; Airlangga, Tri Juda
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i2.580

Abstract

ABSTRACTBackground: Congenital hypothyroidism remains as one of the most common causes of hearing loss in children, considering that thyroid hormone plays an essential role in the development and maturation of auditory organs. Purpose: To report a case of hearing loss in a child with congenital hypothyroidism who had received thyroid hormone replacement therapy. Case report: Presenting a 3-year-old boy with congenital hypothyroidism, growth and developmental delays, and a very severe bilateral sensorineural hearing loss. He was diagnosed at 6 months old, and even after subsequent therapies, the hearing impairment of the child remained profound. Clinical question: Could thyroid hormone replacement therapy improve the prognosis of hearing function in congenital hypothyroid patients accompanied by sensorineural hearing loss? Review method: Literature review through database PubMed, ProQuest, EBSCO, EBSCOhost and Embase, using keywords: “congenital hypothyroidism”, “hearing loss”, and “thyroid hormone replacement therapy”. Result: Screening on 1088 articles found no studies that were relevant with the clinical question and inclusion criteria. Conclusion: This report supported the evidence on the effects of congenital hypothyroidism on hearing loss, and the importance of early diagnosis and prompt treatment in congenital hypothyroid children. A missed diagnosis of congenital hypothyroidism in neonates may result in unfavorable effects on the child’s growth and development. Further studies are needed to assess the improvement of hearing function in congenital hypothyroid patients accompanied by sensorineural hearing loss that received thyroid hormone replacement therapy. ABSTRAKLatar belakang: Hipotiroidisme kongenital merupakan salah satu penyebab paling umum gangguan pendengaran pada anak-anak, terutama mengingat hormon tiroid berperan penting dalam perkembangan dan maturasi organ pendengaran. Tujuan: Melaporkan satu kasus gangguan pendengaran pada anak dengan hipotiroidisme kongenital yang menetap setelah terapi sulih hormon tiroid. Laporan kasus: Seorang anak laki-laki berusia 3 tahun dengan hipotiroidisme kongenital yang mengalami keterlambatan pertumbuhan dan perkembangan, dan gangguan pendengaran tipe sensorineural bilateral derajat sangat berat. Pasien didiagnosis pada usia 6 bulan, dan walaupun setelah terapi, gangguan pendengaran pada anak tersebut menetap. Pertanyaan klinis: Apakah terapi sulih hormon tiroid mempengaruhi prognosis perbaikan fungsi pendengaran pada pasien hipotiroid kongenital yang disertai gangguan pendengaran sensorineural? Tinjauan literatur: Melalui database PubMed, ProQuest, EBSCO, EBSCOhost dan Embase, menggunakan kata kunci: “hipotiroidisme kongenital”, “gangguan pendengaran”, “terapi sulih hormon tiroid”. Hasil: Setelah skrining 1088 artikel, tidak ada penelitian yang sesuai dengan pertanyaan klinis dan kriteria inklusi. Kesimpulan: Laporan ini menambah bukti tentang efek hipotiroidisme kongenital pada gangguan pendengaran, serta pentingnya diagnosis dini dan pengobatan segera pada anak hipotiroid kongenital. Diagnosis hipotiroidisme kongenital yang tidak terdeteksi pada neonatus, dapat mengakibatkan efek buruk pada pertumbuhan dan perkembangan anak. Diperlukan penelitian lebih lanjut untuk menilai prognosis peningkatan fungsi pendengaran pada pasien hipotiroid kongenital dengan gangguan pendengaran sensorineural, yang mendapatkan terapi sulih hormon tiroid.
Penerimaan dan Kegunaan Pengguna untuk Deteksi Dini Gangguan Pendengaran Menggunakan Aplikasi LittlEars: Sebuah Studi Validitas Suharti, Amien; Roselina, Elsa; Ramadhani, Riznadia; Natilda, Fiya; Putranto, Fikri Mirza; Airlangga, Tri Juda; Hawalie, Azwien Niezam
Majalah Kedokteran Indonesia Vol 74 No 5 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.5-2024-1405

Abstract

Introduction: This study aims to evaluate the acceptance among Posyandu cadres of the Littlears application, which is designed to identify hearing impairments in children early on. Method: The LittlEars Questionnaire, designed to identify hearing impairment in children, has evolved into the LittlEars application with the objective of early detection of hearing loss. The evaluation of system usability within the framework of the USE Questionnaire involves four key elements: usability, user-friendliness, learnability, and user satisfaction, and is assessed through 35 specific questions. Result: The usability assessment of the LittlEars application through the USE questionnaire revealed that its usefulness stands at 95.4%, its ease of use at 93.5%, its ease of learning at 92.8%, and satisfaction levels at 94.6%. The average for all dimensions combined is 9.07%. Conclusion: The LittlEars application can be accepted by users, especially Posyandu cadres, and is an application that is easy to use in detecting hearing loss in children.
Efektivitas Kamar Ultraviolet Germicidal Irradiation (UVGI) Rumah Sakit Cipto Mangunkusumo untuk Disinfeksi Respirator N95 di Pandemi COVID-19: Studi Pendahuluan Restuti, Ratna Dwi; Priyono, Harim; Saleh, Rangga Rayendra; Sriyana, Ayu Astria; Yusuf, Prasandhya Astagiri; Airlangga, Tri Juda; Prayitno, Ari; Sitohang, Gortap; Arman, Fitri; Priyanto, Suko Dwi
Majalah Kedokteran Indonesia Vol 72 No 1 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.1-2022-583

Abstract

Introduction: During the COVID-19 pandemic, where the disease might spread in a medical facility setting, the common problems found in every country is the shortage of personal protective equipment (PPE) for medical personnel – especially the disposable N95 respirators. Thus, a higher amplitude to disinfect and reuse N95 is urgently needed. In this study, we designed an effective and safe disinfection methods through an Ultraviolet Germicidal Irradiation (UVGI) chamber in Dr. Cipto Mangunkusumo Hospital to control the shortage of PPE by disinfecting and reusing disposable N95 respirators. Purpose: To evaluate the dosage and effectiveness of UV-C radiation for disposable N95 respirators disinfection in our designated UVGI chamber. Methods: This study used a cross-sectional design to determine the dose and the effectiveness of UV-C radiation in eradicating SARS-CoV 2 on disposable N95 respirators. Results: Using two different distances from the light source, we confirmed the inverse square law of UV-C radiation power. Irradiation for 2 hours with a radiation dose of 1080 mJ/cm2 resulted in undetected SARS-CoV-2 gene based on PCR examination in 10 out of 10 samples. Conclusion: This UVGI chamber is a potential solution for hospitals or medical facilities to overcome the limitations that occurred in the pandemic by disinfecting PPE.
Co-Authors -, FADILAH Ari Prayitno, Ari Arman, Fitri Aryanti, Lestaria Hawalie, Azwien Niezam Muchtarudin Mansyur Natilda, Fiya Priyanto, Suko Dwi Priyono, Harim Putranto, Fikri Mirza Ramadhani, Riznadia Restuti, Ratna Dwi Ronny Suwento, Ronny Safitri, Eka Dwi Saleh, Rangga Rayendra Sitohang, Gortap Soewento, Ronny Sriyana, Ayu Astria Suharti, Amien Tri Handayani Widiarni, Dini Yassi, Duhita Yusuf, Prasandhya Astagiri Zizlavsky, Semiramis