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All Journal Conservative Dentistry Journal Indonesian Journal of Community Empowerment
Setyabudi, Setyabudi
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Agriculture, Biological Sciences & Forestry Humanities Dentistry Education Environmental Science Public Health

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Toxicity test of bioceramic biphasic calcium phospate (BCP) Sr-Ag doping as bone graft in BHK-21 fibroblast cells Wahjuningrum, Dian Agustin; Setyabudi, Setyabudi; Chusnita, Ria
Conservative Dentistry Journal Vol. 13 No. 1 (2023): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v13i1.2023.33-36

Abstract

Background: Bone graft is a substitute material that is used to assist reconstruction, stabilize the structure and bonds in bone, stimulate the osteogenesis process and as a healing bone defect. One type of bone graft that has good osteoinductive and bicompatibility is alloplast which is a synthetic calcium phosphate compound. The most frequently used Calcium Phosphate groups are Hydroxyapatite (HA), β-Tricalcium Phosphate (β-TCP), and Biphasic Calcium Phosphate (BCP). In this study the material used was BCP doping Sr2+ and Ag+. Strontium ions (Sr2+) can increase osteoblast activity, reduce osteoclast activity and cytokine production, improve osteointegration, and minimize fractures. Ag+ ion has the ability as an antibacterial agent. Purpose: To explain and prove the toxicity of bioceramic Biphasic Calcium Phosphate (BCP) doped Sr-Ag as bone graft on BHK-21 fibroblast cells. Methods: This type of research is a laboratory experiment with a post-test only control group design. Treatment with Biphasic Calcium Phosphate (BCP) doped Sr-Ag with concentrations of 200 ppm, 180 ppm, 160 ppm, 140 ppm, 120 ppm, 80 ppm, 40 ppm, 20 ppm, 10 ppm, 5 pmm, 2.5 ppm, 1.25 ppm, 0.625 ppm in BHK-21 fibroblast cell culture. Results: The percentage of fibroblast cell life at concentrations of 200 ppm, 180 ppm, 160 ppm, 140 ppm, 120 ppm, 80 ppm, 40 ppm, 20 ppm, 10 ppm, 5 pmm, 2.5 ppm, 1.25 ppm, 0.625 ppm, respectively, the percentage of live cells was 38% 44%, 46%, 50%, 52%, 65%, 69%, 71%, 72%, 75%, 77%, 81%, and 87%. The parameter used in this toxicity test is CD50. Conclusion: The results of the toxicity test of bioceramic Biphasic Calcium Phosphate (BCP) doped Sr-Ag as a bone graft showed a toxic and non-toxic effect on BHK-21 fibroblast cells at certain concentrations.
SOSIALISASI URBAN FARMING BAGI KARANG TARUNA DAN UMKM KELURAHAN PESANTREN KECAMATAN MIJEN  SEMARANG Parju, Parju; Nurchayati, Nurchayati; Suyati, Suyati; Suparmi, Suparmi; Setyabudi, Setyabudi; Suroto, Suroto; Aminah, Siti; Wibowo, Agung; Suprapti, Sri; Muchayatin, Muchayatin
MAJU : Indonesian Journal of Community Empowerment Vol. 2 No. 3 (2025): MAJU : Indonesian Journal of Community Empowerment, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/maju.v2i3.1249

Abstract

This socialization aims to encourage increased capacity for Karang Taruna and UMKM in Pesantren Village, Mijen District, Semarang City. In order for Karang Taruna and UMKM to improve, socialization and training in catfish farming are needed. Catfish farming is widely favored by the Indonesian people and is developing in both villages and cities. Catfish is a freshwater fish, easily cultivated commercially by the Indonesian people. Catfish farming is growing rapidly because it can be cultivated with limited land and water sources with high stocking density, relatively easy cultivation technology and relatively low business capital, so it is natural that this business is widely favored, because the demand for catfish continues to increase.
Co-Authors Agung Wibowo Chusnita, Ria Dian Agustin Wahjuningrum Muchayatin, Muchayatin Nugraha, Asta Nurchayati Nurchayati Parju, Parju Siti Aminah Sri Suprapti Suparmi Suparmi Suroto Suroto Suyati -