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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Journal of Public Health Science (JoPHS) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Khairunnisa, Nadiah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Analisis Cemaran Daging Babi pada Bakso Sapi yang Dijual di Tanjung Priok menggunakan Real-Time Polymerase Chain Reaction (RT-PCR) Zilhadia, Zilhadia; Adhiyanto, Chris; Gustida, Ayu; Khairunnisa, Nadiah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 1 (2020): J Sains Farm Klin 7(1), April 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.1.83-91.2020

Abstract

Bakso sapi sebagai makanan yang disukai oleh masyarakat Indonesia rawan terhadap cemaran daging babi karena daging sapi harganya relatif mahal. Kasus pencampuran tersebut tentu menimbulkan ketidaknyamanan bagi masyarakat muslim di Indonesia karena daging babi tidak halal dikonsumsi. Karena itu perlu dilakukan analisis cemaran daging babi pada bakso sapi. Sampel diambil dari wilayah Tanjung Priuk karena jumlah penganut yang boleh mengkonsumsi daging babi di daerah tersebut signifikan banyaknya. Bakso kontrol (100% babi, 100% sapi, campuran 50% babi) dan 10 bakso sampel di analisis menggunakan metode real-time polymerase chain reaction (RT-PCR). Isolat DNA yang digunakan adalah DNA mitokondria dengan daerah target sitokrom B. Hasil amplifikasi RT-PCR pada 3 bakso kontrol menggunakan primer babi menunjukkan bakso kontrol 100% babi dan campuran 50% babi menghasilkan kenaikan kurva amplifikasi dengan CP 22,82 dan 20,03. Sedangkan hasil amplifikasi 10 sampel bakso sapi menggunakan primer babi tidak menghasilkan kenaikan kurva amplifikasi yang menunjukkan bahwa tidak adanya DNA babi yang teramplifikasi pada produk bakso sapi tersebut.
Pharmacogenomic Regulation Of The NF-KB-NRF2 Axis By Curcumin: A Precision Molecular Approach to Inflammation and Oxidative Stress Alisya, Questa Soundri Alisya; Khairunnisa, Nadiah
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Book of Abstrack RCIMS 2025
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.948

Abstract

Introduction: Chronic inflammation and oxidative stress are major mechanisms in degenerative diseases, including cancer, diabetes, and cardiovascular disorders. The NF-kB and Nrf2 pathways play a role in maintaining redox balance and inflammatory response. Curcumin, the main bioactive compound of Curcuma longa L., can simultaneously modulate both pathways through pharmacogenomic mechanisms influenced by individual genetic variations. Methods: This study used the Systematic Literature Review method in accordance with the PRISMA 2020 guidelines. Searches were conducted in PubMed, Scopus, ScienceDirect, and Google Scholar until October 2025 using the keywords “Curcumin,” “NF-kB,” “Nrf2,” “Oxidative Stress,” and “Pharmacogenomics.” Studies assessing the molecular modulation of NF-kB/Nrf2 by curcumin and gene-dependent effects were included. Results and Discussion: A total of 31 studies met the inclusion criteria, including in vitro, in vivo, in silico, and clinical studies. Curcumin suppressed NF-kB activation and activated Nrf2/HO-1, thereby reducing ROS and proinflammatory cytokines. Variations in the ERCC5 rs751402 gene, as well as the expression of SLC7A11 and ATAD3A/B, influenced the cellular response to curcumin. In silico and network pharmacology analyses revealed multigenic targets related to inflammation and oxidative stress. Nanoformulations enhance bioavailability and clinical immune response. Conclusion: Curcumin acts as a dual-regulator pharmacogenomic agent that balances the NF-kB and Nrf2 pathways, reducing inflammation and oxidative stress in a gene-dependent manner. These findings support its potential as a natural biomolecule for the development of precision therapies for chronic diseases involving inflammation and oxidative stress. Keywords: Curcumin, NF-kB, Nrf2, Oxidative Stress, Pharmacogenomics
FAKTOR-FAKTOR YANG MEMPENGARUHI OBESITAS PADA ANAK DALAM LITERATUR KONTEMPORER: LITERATURE REVIEW Septriani, Fany; Khairunnisa, Nadiah; Akbar, Resti Rahmadika; Hariyani, Insil Pendri; Anissa, Mutiara
Journal of Public Health Science Vol. 3 No. 1 (2026): Maret
Publisher : Yayasan Nuraini Ibrahim Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70248/jophs.v3i1.3666

Abstract

Childhood obesity is a major global public health concern due to its increasing prevalence and long-term health consequences. The World Health Organization (WHO) reports that the prevalence of childhood obesity has risen significantly worldwide over the past decades. Childhood obesity not only affects physical health but also increases the risk of psychological and social problems. An imbalance between energy intake and energy expenditure over time leads to excessive fat accumulation, resulting in overweight and obesity. Body Mass Index (BMI) above normal levels is commonly used to indicate obesity in children. The primary cause of obesity is the accumulation of excess body fat due to excessive energy intake relative to energy needs. Childhood obesity is influenced by multiple factors, including genetic, maternal, nutritional, and socio-economic factors. These factors interact to shape dietary patterns, food choices, and physical activity levels, ultimately contributing to the development of obesity in children.
Co-Authors Akbar, Resti Rahmadika Alisya, Questa Soundri Alisya Anissa, mutiara CHRIS ADHIYANTO Gustida, Ayu Hariyani, Insil Pendri Septriani, Fany Zilhadia Zilhadia