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All Journal Jurnal Respirasi (JR) Indonesian Journal of Global Health Research
Wesnawa, Made Agustya Darma Putra
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Udayana University, Denpasar, Indonesia.
Health Professions Medicine & Pharmacology Public Health

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Emerging Role of Precision Medicine in Diagnosis and Treatment of Chronic Respiratory Disease Wesnawa, Made Agustya Darma Putra; Asmara, Oke Dimas; Supadmanaba, I Gede Putu
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.85-92

Abstract

Precision medicine is the current approach to managing chronic respiratory diseases, especially asthma and chronic obstructive pulmonary disease (COPD). It involves the evaluation of genetic, environmental, and lifestyle variations for each patient. It requires valid and specific biomarkers obtained through genetic studies, biomolecular technology, and omics-based technology to determine targeted therapies. Asthma and COPD have heterogeneous clinical phenotype variations, and giving one standard treatment for asthma and COPD may not necessarily provide the same effectiveness to other patients. The endotype, a specific molecular mechanism in disease pathogenesis, is essential in phenotype variation. The role of precision medicine in asthma and COPD is to determine endotypes through specific biomarkers and to provide specific targeted therapy for achieving personalized treatment in each patient. The application of precision medicine not only provides precise diagnosis and treatment but also enables early detection in individuals at risk and prevention of progression and exacerbation in asthma and COPD.
Lung Aging and Lung Function Assessment in Elderly Wesnawa, Made Agustya Darma Putra; Subagiarta, I Made; Nathania, Evelyn
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.93-100

Abstract

The lung is one of the organs that experiences the most frequent decline in function among the elderly. Reduced lung function associated with aging is a physiological condition. The lungs transform both their cellular composition and their functional capabilities. The lungs of an aging population may show structural changes to the respiratory muscles, chest wall, lung parenchyma, and upper and lower respiratory tracts. The elderly are more susceptible to reduced lung perfusion, respiratory mechanics, infection, and weaker respiratory muscles because of aging. The body plethysmograph, oscillometer, spirometry, and carbon monoxide (CO) diffusing lung capacity are techniques used to assess lung function in the elderly. For elderly people, lung function testing might be challenging due to frailty and cognitive decline. Consequently, choosing the best lung function test method for the elderly and offering an accurate and suitable interpretation of the test findings are crucial. Early detection of changes in lung function and accurate assessment of lung function can help identify lung function abnormalities in the elderly and give the appropriate treatment and intervention. This review focused on lung aging, the potential benefits and drawbacks of different lung function tests in the elderly, and the proper way to interpret specific lung function tests.
Early Detection of Chronic Obstructive Pulmonary Disease in Limestone Quarry Communities with Puma Score and Portable Spirometry Made Agustya Darma Putra Wesnawa; I Gusti Ngurah Bagus Artana; I Desak Putu Agung Krisdanti; Putu Gita Indraswari; Made Indira Shinta Pratiwi; Maria Carlina
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2805

Abstract

Chronic obstructive pulmonary disease (COPD) remains underdiagnosed in primary care, particularly in communities with occupational dust exposure and limited access to spirometry. Objective: This study described COPD risk profiles and examined factors associated with airflow obstruction among adults in a limestone quarry community in Ungasan, Bali. A community-based cross-sectional study design was utilized in this research, with a total of 50 participants selected via a consecutive sampling technique. Data included demographic characteristics, body mass index, smoking history, occupational and biomass exposure, PUMA questionnaire score, and portable spirometry. Airflow obstruction was defined from spirometric interpretation recorded in the screening database. Categorical associations were analysed using two-sided exact tests and odds ratios. Results: Participants had a mean age of 50.0 ± 19.8 years; 56.0% were male and 46.0% were obese. Nine participants (18.0%) were classified as high-risk by PUMA, while airflow obstruction was found in six participants (12.0%). Ever or current smoking was associated with obstruction (31.2% versus 2.9%; OR 15.00; 95% CI 1.58-142.73; p=0.010). Brinkman Index ≥200 and high-risk PUMA status showed elevated odds but did not reach statistical significance. Targeted community screening using PUMA and portable spirometry can identify undetected airflow obstruction in dusty occupational settings, with smoking history remaining the clearest risk marker.
Co-Authors Asmara, Oke Dimas I Desak Putu Agung Krisdanti I G. P. Supadmanaba I Gusti Ngurah Bagus Artana Made Indira Shinta Pratiwi Maria Carlina Nathania, Evelyn Putu Gita Indraswari Subagiarta, I Made