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Wesnawa, Made Agustya Darma Putra
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Health Professions Medicine & Pharmacology Public Health

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Emerging Role of Precision Medicine in Diagnosis and Treatment of Chronic Respiratory Disease Wesnawa, Made Agustya Darma Putra; Asmara, Oke Dimas; Supadmanaba, I Gede Putu
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.85-92

Abstract

Precision medicine is the current approach to managing chronic respiratory diseases, especially asthma and chronic obstructive pulmonary disease (COPD). It involves the evaluation of genetic, environmental, and lifestyle variations for each patient. It requires valid and specific biomarkers obtained through genetic studies, biomolecular technology, and omics-based technology to determine targeted therapies. Asthma and COPD have heterogeneous clinical phenotype variations, and giving one standard treatment for asthma and COPD may not necessarily provide the same effectiveness to other patients. The endotype, a specific molecular mechanism in disease pathogenesis, is essential in phenotype variation. The role of precision medicine in asthma and COPD is to determine endotypes through specific biomarkers and to provide specific targeted therapy for achieving personalized treatment in each patient. The application of precision medicine not only provides precise diagnosis and treatment but also enables early detection in individuals at risk and prevention of progression and exacerbation in asthma and COPD.
Lung Aging and Lung Function Assessment in Elderly Wesnawa, Made Agustya Darma Putra; Subagiarta, I Made; Nathania, Evelyn
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.93-100

Abstract

The lung is one of the organs that experiences the most frequent decline in function among the elderly. Reduced lung function associated with aging is a physiological condition. The lungs transform both their cellular composition and their functional capabilities. The lungs of an aging population may show structural changes to the respiratory muscles, chest wall, lung parenchyma, and upper and lower respiratory tracts. The elderly are more susceptible to reduced lung perfusion, respiratory mechanics, infection, and weaker respiratory muscles because of aging. The body plethysmograph, oscillometer, spirometry, and carbon monoxide (CO) diffusing lung capacity are techniques used to assess lung function in the elderly. For elderly people, lung function testing might be challenging due to frailty and cognitive decline. Consequently, choosing the best lung function test method for the elderly and offering an accurate and suitable interpretation of the test findings are crucial. Early detection of changes in lung function and accurate assessment of lung function can help identify lung function abnormalities in the elderly and give the appropriate treatment and intervention. This review focused on lung aging, the potential benefits and drawbacks of different lung function tests in the elderly, and the proper way to interpret specific lung function tests.
Co-Authors Asmara, Oke Dimas I G. P. Supadmanaba Nathania, Evelyn Subagiarta, I Made