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All Journal Jurnal Respirasi (JR) Jurnal Abdi Masyarakat Indonesia Folia Medica Indonesiana
Syafa'ah, Irmi
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Health Professions Medicine & Pharmacology Neuroscience Public Health

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The Effect of Vitamin D3 Supplementation on Interleukin-6 and PRESS Score in Children with Pneumonia and Vitamin D Deficiency Setyoningrum, Retno Asih; Kristianto, Wigit; Chafid, Arda Pratama Putra; Hapsari, Rika; Syafa'ah, Irmi
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.107-113

Abstract

Introduction: Pneumonia is a significant health issue in children under 5 years old. Vitamin D may help to reduce childhood mortality, morbidity, and interleukin-6 (IL-6) levels in children with pneumonia, but the evidence is still limited and controversial. This study aimed to evaluate the effect of vitamin D3 supplementation on IL-6 levels and clinical manifestations in children with pneumonia and vitamin D inadequacy. Methods: This was a randomized, placebo-controlled, and double-blinded trial study. Twenty-eight children diagnosed with pneumonia and vitamin D deficiency were enrolled and divided into a supplementation (n=15) or placebo group (n=13). Children were given a single dose (100,000 international units/IU) of vitamin D3 or placebo on the first day of hospitalization. Clinical manifestations were assessed by the Pediatric Respiratory Severity Score (PRESS). Results: The level of 25-hydroxyvitamin D (25-OH D3), IL-6, and PRESS score at baseline showed no significant difference between groups. Seven days post-supplementation, only the PRESS score showed a significant difference between groups (p=0.025). Analysis of the vitamin D3 group showed a significantly increased 25-OH D3 level and a reduced PRESS score (p=0.039 and p=0.02, respectively). Conclusion: A single high dose of vitamin D3 supplementation in children with pneumonia and inadequate vitamin D levels helps elevate 25-OH D3 levels and reduce clinical manifestations, as indicated by the PRESS score.
Bilateral Multiple Lower Limb Tuberculous Aneurysms in a Pregnant Woman with Drug-Induced Liver Injury due to Tuberculosis Treatment Almadina, Farah; Prinasetyo, Kana Wulung Arie Ichida; Roziqo, Dewi; Syafa'ah, Irmi
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.256-262

Abstract

Introduction: Tuberculosis (TB) is a long-term infectious disease caused by Mycobacterium tuberculosis (MTB). It can occur during pregnancy, in which its treatment can cause side effects, such as drug-induced liver injury (DILI). Tuberculous aneurysm due to TB infection is a rare occurrence, which can spread directly and hematogenously from the vascular wall. We report a case of bilateral multiple lower limb tuberculous aneurysms in a pregnant woman with DILI due to TB treatment. Case: A 27-year-old pregnant woman at 14-15 weeks of gestation presented with painless lumps on the left side of her neck and both ankles. Fine needle aspiration biopsy (FNAB) of the left cervical lymph nodes confirmed tuberculous lymphadenitis. Vascular Doppler ultrasound of both lower limbs revealed multiple aneurysms, suspected to be infected tuberculous aneurysms with intramural thrombi, located on the lateral and anterior aspects of the distal leg extending to the left ankle, compressing the distal posterior and anterior tibial arteries. After one month of category one anti-TB drug (ATD) therapy, the patient developed elevated bilirubin levels (3.76 mg/dL). Following surgical intervention, the anti-TB regimen was resumed, leading to the resolution of the pseudoaneurysms by the fifth month of treatment. Conclusion: Tuberculous aneurysm in pregnant patients with TB is a rare and potentially life-threatening condition. It is difficult to diagnose, but TB infection should be considered a possible cause in endemic countries. Surgery combined with anti-TB treatment improves outcomes.
Conservative Management of Chest Tube and Ambulatory Water Sealed Drainage in Persistent Pneumothorax due to Tuberculosis Candrawati, Ni Wayan; Sanjaya, Franciscus; Syafa'ah, Irmi
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.263-268

Abstract

Introduction: Pneumothorax is characterized by the presence of air in the pleural cavity, which can result from various pulmonary conditions, including tuberculosis (TB). Conservative management, including the use of chest tubes with ambulatory water-sealed drainage (WSD), offers a viable alternative for patients who are ineligible for surgery or decline surgical intervention. This case report aimed to highlight that all treatment options should be discussed with the patient to determine their primary priority, with consideration for the least invasive option. Case: A 22-year-old woman with secondary spontaneous pneumothorax due to TB presented with shortness of breath following a cough and was found to have a >2cm lucent area on chest X-ray. Initial management included chest tube insertion and WSD. A persistent pneumothorax was identified after 13 days of admission, and surgery was advised, but the patient declined. Conservative management was continued with ambulatory drainage for a total of 34 days, and management of TB as an underlying disease, and adequate nutritional support. Over the course of a month, clinical symptoms improved, and subsequent evaluations confirmed resolution of the pneumothorax. The chest tube was removed. The patient completed 12 months of anti-TB therapy, was declared cured, and experienced no recurrence of pneumothorax. Conservative management, including ambulatory WSD, effectively manages persistent air leak (PAL) for patients unsuitable for surgery. Ambulatory WSD facilitates mobility, reduces hospital stay, and minimizes complications. Proper patient education, nutritional support, and management of underlying conditions are essential for favorable outcomes. Conclusion: The management of persistent pneumothorax should be guided by the patient’s clinical condition. Conservative management can yield favorable results, followed by best supportive management.
The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Khaerunnisa, Siti; Syafa'ah, Irmi; Wungu, Citrawati Dyah Kencono; Prabowo, Gwenny Ichsan; Handajani, Retno; Safitri, Indri; Notopuro, Harianto; Qurnianingsih, Ema; Lukitasari, Lina; Humairah, Ira; Bakhtiar, Arief; Suwandito, Suwandito; Asih, Susi Wahyuning; Anggraeni, Zuhrotul Eka Yulis; Adi, Ginanjar Sasmito; Nugrahani, Ely Rahmatika; Zulka, Ayesie Natasha; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.
Case Report: Survival of A Coronavirus Disease-2019 (Covid-19) Patient with Acute Respiratory Distress Syndrome (ARDS) in Dr. Soetomo Hospital, Surabaya, Indonesia Soedarsono, Soedarsono; Semedi, Bambang Pudjo; Setiawati, Rosy; Meliana, Resti Yudhawati; Kusmiati, Tutik; Permatasari, Ariani; Bakhtiar, Arief; Syafa'ah, Irmi; Indrawanto, Dwi Wahyu
Folia Medica Indonesiana Vol. 56, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that began in Wuhan, China has spread rapidly in multiple countries of the world and has become a pandemic. Currently, there is no vaccine or specific antiviral for COVID-19. A study reported 7.3% of critical patients admitted to ICU, 71% of them required mechanical ventilation, and 38.5% of them were survived. Herein, we reported a 54 year old man with Acute Respiratory Distress Syndrome (ARDS) of COVID-19 who survived the disease. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasopharyngeal and oropharingeal swabs were positive for SARS-CoV-2. Diagnosis of ARDS was also according to clinical symptoms, laboratory, chest radiograph, and chest CT scan. Alcaligenes faecalis and Candida albicans were also identified from sputum culture. Treatment for this patient was causal and supportive therapy, including antibiotic, antiviral, and antifungal therapy according to the culture results, fluid resuscitation, and oxygen supply from the mechanical ventilator. This patient was survived and discharged on hospital day-29. A fibrosis in parenchyma pulmonary and sensory peripheral neuropathy occurred after survived from ARDS. Monitoring of clinical, laboratory, and chest radiograph were continued after the patient discharged from the hospital. This case highlights the importance of early diagnosis and effective treatment to the care of COVID-19 patient.
Predicting Prolonged Hospitalization in Pneumonia: The Role of Lung Injury Score Putri, Mayandra Alif Anggita; Marhana, Isnin Anang; Hakim, Arief Rakhman; Bakhtiar, Arief; Syafa'ah, Irmi
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.27-34

Abstract

Introduction: Pneumonia is a lung infection with a high prevalence and is associated with prolonged length of stay (LOS). An excessive LOS increases the risk of complications, while a short LOS may lead to inadequate treatment. The lung injury score (LIS), which assesses the severity of lung injury and respiratory dysfunction, is expected to be an accurate predictor of LOS in patients with pneumonia. This study aimed to determine the correlation between LIS and LOS in hospitalized patients with pneumonia. Methods: This retrospective cohort study included adult patients hospitalized at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, with a diagnosis of pneumonia between January and December 2023. The LIS component scores (chest X-ray findings, arterial partial pressure of oxygen-to-fractional inspired oxygen ratio, positive end-expiratory pressure (PEEP), and static lung compliance) were obtained from electronic medical records and used to calculate LIS values. The correlation between LIS and LOS was analyzed using the Spearman test, while the cut-off point was determined using receiver operating characteristic (ROC) curve analysis. Results: A total of 152 patients fulfilled the inclusion criteria. The mean LIS was 1.82±0.89, while the mean LOS was 10.23±6.27 days. A statistically significant correlation was found between LIS and LOS (p<0.001) with a correlation coefficient of 0.317. Receiver operating characteristic curve analysis identified the optimal LIS cut-off point for an LOS of 10 days as 1.75. Conclusion: There was a statistically significant correlation between LIS and LOS in patients with pneumonia. The LIS cut-off point of 1.75 for an LOS of 10 days was statistically significant.
Pengabdian Masyarakat melalui Penyuluhan dan Pemberian Modul Tuberkulosis (TB) Paru sebagai Upaya Peningkatan Pengetahuan dan Kinerja Kader TB di Pondok Pesantren Annuqoyah, Kabupaten Sumenep, Jawa Timur Bakhtiar, Arief; Kusmiati, Tutik; Syafa'ah, Irmi; Tanoto, Julius; Aulia Rahman, Nuha; Rahmawati Hariputri, Wulan; Najich Riza Firmansyah, Achmad; Maulaningtyas, Hamidia; Firdausi Rafidah, Salsabila
Jurnal Abdi Masyarakat Indonesia Vol 6 No 1 (2026): JAMSI - Januari 2026
Publisher : CV Firmos

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54082/jamsi.2464

Abstract

Eliminasi tuberkulosis (TB) masih menjadi tantangan kesehatan masyarakat di Indonesia, termasuk di Kabupaten Sumenep, yang pada tahun 2021 belum mencapai target penemuan dan pengobatan kasus TB. Tingginya jumlah pondok pesantren di wilayah ini menjadikan pesantren sebagai sasaran strategis dalam upaya eliminasi TB. Pondok pesantren dengan kepadatan hunian dan intensitas kontak antar santri yang tinggi berpotensi meningkatkan risiko penularan. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan dan peran kader TB pesantren yang telah ditunjuk dalam mendukung upaya eliminasi TB. Kegiatan dilaksanakan di Pondok Pesantren Annuqayah, Kecamatan Guluk-Guluk, Kabupaten Sumenep, yang sebelumnya belum memiliki kader TB pesantren. Pengabdian masyarakat dilakukan melalui penyuluhan dengan metode ceramah, diskusi, dan simulasi, disertai pemberian modul TB paru dan lembar balik sebagai media edukasi. Evaluasi dilakukan menggunakan pretest dan posttest, kemudian dianalisis dengan uji t berpasangan. Hasil menunjukkan peningkatan pengetahuan kader yang signifikan, dengan nilai rata-rata pretest sebesar 36,87 meningkat menjadi 71,96 pada posttest (p=0,000). Selain itu, kader menunjukkan peningkatan peran aktif melalui penemuan santri terduga TB dalam tiga bulan setelah kegiatan. Kegiatan ini efektif dalam meningkatkan kapasitas kader TB pesantren dan diharapkan dapat memperkuat peran kader dalam mendukung eliminasi TB di lingkungan pesantren.
Co-Authors Adi, Ginanjar Sasmito Almadina, Farah Anggraeni, Zuhrotul Eka Yulis Aulia Rahman, Nuha Bakhtiar, Arief Candrawati, Ni Wayan Chafid, Arda Pratama Putra Ely Rahmatika Nugrahani, Ely Rahmatika Firdausi Rafidah, Salsabila Hakim, Arief Rakhman Hapsari, Rika Harianto Notopuro Humairah, Ira Indrawanto, Dwi Wahyu Indri Safitri, Indri Isnin Anang Marhana Khaerunnisa, Siti Kristianto, Wigit Kusmiati, Tutik Kusmiati, Tutik Lukitasari, Lina Maulaningtyas, Hamidia Najich Riza Firmansyah, Achmad Permatasari, Ariani Prabowo, Gwenny Ichsan Prinasetyo, Kana Wulung Arie Ichida Putri, Mayandra Alif Anggita Qurnianingsih, Ema Rahmawati Hariputri, Wulan Resti Yudhawati Retno Asih Setyoningrum Retno Handajani Roziqo, Dewi Sanjaya, Franciscus Semedi, Bambang Pudjo Setiawati, Rosy Soedarsono Soedarsono SOETJIPTO . Susi Wahyuning Asih, Susi Wahyuning Suwandito, Suwandito Tanoto, Julius Wungu, Citrawati Dyah Kencono Zulka, Ayesie Natasha