Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Jurnal Gizi Journal of Nutrition College
Madjid, Indah Juliana
Unknown Affiliation
Environmental Science Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
IDENTIFIKASI POTENSI SENYAWA ISOFLAVON DAN QUERCETIN DAN PERBANDINGAN IKATAN TERHADAP ACE (ANGIOTENSIN-CONVERTING ENZYME) MENGGUNAKAN STUDI IN SILICO Nissa, Choirun; Sukma, Guritan Indra; Madjid, Indah Juliana; Sidin, Nur Mariyah; Musyarrofah, Maulidatul
Journal of Nutrition College Vol 11, No 1 (2022): Januari
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v11i1.29500

Abstract

Prevalensi hipertensi di Indonesia tergolong tinggi, sekitar 29,1% pada laki-laki dan perempuan sebesar 26,6%. Penderita hipertensi di Jawa Timur juga tergolong tinggi, sebanyak 31.789 orang. Solusi alternatif dalam penelitian ini, memanfaatkan isoflavon dan quercetin sebagai antihipertensi. Isolavon dan quercetin merupakan seyawa fenolik yang mampu berikatan dengan Angiotensin Converting Enzyme(ACE) dan mempengaruhi tekanan darah. Penelitian ini mengidentifikasi potensi senyawa isoflavon dan quercetin serta perbandingan ikatan antara isoflavon dan quercetin terhadap ACE dengan menggunakan perangkat lunak Hex 8. Penelitian ini adalah deskriptif kuantitatif dengan penelusuran melalui metode in silico (pengunduhan molekul dan penambatan molekul) secara komputerisasi.  Softwareatau aplikasi yang digunakan pada penelitian ini adalah pass server dan HEX 8.0. Hasil visualisasi penambatan molekul ditampilkan dengan perangkat lunak Discovery Studio. Hasil penelitian ini menunjukkan bahwa senyawa quercetin dan isoflavone berpotensi sebagai vasoprotektor. Energi penambatan molekul Isoflavon terhadap ACE sebesar -194,66 kkal.mol. Quercetin sebesar -236,47 kkal.mol, Captopril sebesar -494.56 kkal/mol. Energi penambatan ligan isoflavon dan quercetin terhadap ACE (Angiotensin Converting Enzyme) lebih besar daripada penambatan ligan Captopril terhadap ACE (Angiotensin Converting Enzyme). Hasil penelitian ini memberi harapan potensi penggunaan senyawa ligan sebagai antihipertensi namun memerlukan penelitian lebih lanjut.
Perbandingan Jenis Cairan Rehidrasi terhadap Tingkat Dehidrasi dan VO2 Maksimal pada Remaja Putri Peserta Ekstrakurikuler Bola Basket Nissa, Choirun; Madjid, Indah Juliana; Januardo, Ferdian Hapreda
Jurnal Gizi Vol 10, No 2 (2021): Jurnal Gizi UNIMUS
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jg.10.2.2021.1-9

Abstract

Indonesia currently tends to have fluctuative achievement in sports, especially in basketball. The sports performance can be affected by several things, which are relatedto the fulfillment of nutritional adequacy. Balance of fluid is one of essential intakes forathletes. This study aimed to analyze the comparison of rehydration fluids type todehydration level and vo2max on female teens of basketball extracurricular participants.This study design was quasy experiment with posttest only group design. Thetreatments in this study were divided into 3 groups, the first is water-given group, thesecond water-CHO 6%-given group and the third is isotonic water-given group. Alltreatments were performed to 8 female teens of basketball extracurricular participantson the different days. The results of Kruskal-Wallis statistical test showed difference in the level ofdehydration in a variety of treatments (p = 0.0001). Based One Way Anova there wereno differences in the various treatments VO2max (p = 0.180). The conclusion of thisresearch was that providing isotonic water could help reach the best level of hydrationfor an athlete during training. Key words: Dehydration Level, VO2max, Rehydration Fluid
Co-Authors Januardo, Ferdian Hapreda Musyarrofah, Maulidatul Nissa, Choirun Sidin, Nur Mariyah Sukma, Guritan Indra