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All Journal Jurnal Farmasi Sains dan Komunitas Makara Journal of Health Research
Gulo, Lise Insani
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Medicine & Pharmacology

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THE EFFECT OF CANDESARTAN PRE-STROKE USE ON THE FUNCTIONAL OUTCOME OF POST ISCHEMIC STROKE PATIENTS IN BETHESDA HOSPITAL YOGYAKARTA Lise Insani Gulo; Rizaldy Taslim Pinzon; Esdras Ardi Pramudita
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 1 (2018)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.882 KB) | DOI: 10.24071/jpsc.00660

Abstract

Stroke is a leading cause of death and disability, where the main risk factor is hypertension. Angiotensin Receptor Blocker (ARB) is the most common drug for stroke prevention in high-risk hypertensive patients. The purpose of this study was to see whether the candesartan pre-stroke use can improve the functional outcomes of post ischemic stroke patients. The data were obtained from 191 retrospective observational studies. Data were collected from Stroke Registry and medical record at Bethesda Hospital Yogyakarta in 2014-2016, then analyzed univariate, followed by bivariate analysis using chi-square test, independent t-test and fisher exact test for the variable which has actual count (F0), and logistic regression for multivariate analysis. One hundred and ninety one samples were systematically reviewed to evaluate the effect of candesartan pre-stroke use on functional outcomes of post ischemic stroke patients in Bethesda hospital Yogyakarta whose range of ages was mostly between 61 and 70 years (30.9%) and were mostly male patients (56.5%). Patients with good functional outcomes (2) were 79.6% and poor functional outcomes (?2) were 20.4%. The results of bivariate analysis showed that candesartan did not affect the improvement of clinical outcome (OR: 1.806, 95% CI: 0.591-5.519, p: 0.294), and also not better than other angiotensin receptor blocker (p=0.505, OR=1.472, 95% CI= 0.470-4.611). The multivariate analysis showed that sex (OR: 0.366, 95% CI: 0.156-0.858, p: 0.021), loss of consciousness (OR: 0.107, 95% CI: 0.021-0.549, p: 0.007), limb weakness (OR: 0.236, 95% CI: 0.067-0.834, p: 0.025), dyslipidemia comorbidity (OR: 2.750, 95% CI: 1.177-6.427, p: 0.019) and aphasia (OR: 0.342, 95% CI: 0.107-1.100, p: 0.072) affected the functional outcome. The candesartan pre-stroke use did not improve the functional outcome of post ischemic stroke patient.
Caregivers of Elderly with Moderate to Total Dependence in Activities of Daily Living in Yogyakarta Indonesia: Correlation of Burden and Quality of Life Widagdo, The Maria Meiwati; Gulo, Lise Insani; Cendrasilvinia, Herose; Manus, Widya Christine
Makara Journal of Health Research Vol. 26, No. 3
Publisher : UI Scholars Hub

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Abstract

Background: Aging is accompanied by a functional decline leading to the loss of independence in conducting activities of daily living. The dependence of the elderly can cause burden that affects the quality of life of caregivers. This study aimed to assess the correlation between the burden and quality of life of caregivers looking after moderately to totally dependent elderly. Methods: This research is a cross-sectional study that used Zarit Burden Interview to assess caregiver burden and World Health Organization Quality of Life to measure the quality of life of people caring for elderly with moderate to total dependence based on the scores in Activities of Daily Living and Instrumental Activities of Daily Living questionnaires. The data were analyzed using Spearman’s rank correlation test. Results: A total of 30 caregivers participated in this study. Significant negative correlations were observed between the burden and quality of life of caregivers of elderly with moderate to total dependence in all four domains: physical (p = 0.001), psychological (p < 0.001), social relationships (p = 0.028), and environmental (p < 0.001). Conclusions: The findings imply that the burden of caring for the elderly with moderate to total dependence may affect the caregivers’ burden and quality of life in all domains.
Co-Authors Cendrasilvinia, Herose Esdras Ardi Pramudita Manus, Widya Christine Rizaldy Taslim Pinzon The Maria Meiwati Widagdo