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Salendu, Praevilia Margareth
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Health Professions Medicine & Pharmacology

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Risk factors for sleep disturbances and low quality of life in adolescents with epilepsy Salendu, Praevilia Margareth; Manurung, Elsa Ameliana
Paediatrica Indonesiana Vol. 65 No. 2 (2025): March 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.2.2025.117-21

Abstract

Background Epilepsy impacts health-related quality of life and increases sleep disturbances. Duration of medication use, recurrent seizures, number of anti-epileptic drugs (AEDs), abnormal electroencephalography (EEG), and comorbidities are factors that might affect sleep and quality of life in adolescents with epilepsy. Objective To analyze risk factors related to sleep disturbances and quality of life in adolescents with epilepsy. Methods This analytical-observational study was performed in epilepsy outpatients treated between January – June 2024, of adolescent age, and had used AEDs for more than a year. Quality of life was evaluated using the Pediatric Quality of Life InventoryTM (PedsQLTM) – Epilepsy Module, and sleep disturbances were evaluated using the Sleeping Disturbance Scale for Children (SDSC) questionnaire. Fisher’s and Kolmogorov-Smirnov analyses were performed along with logistic regression for multivariate analysis. Results Forty-eight patients participated in this study. Subjects’ mean age was 12.69 (SD 2.4) years and 54.2% of subjects were male. Mean duration of medication use was 2 years with the minimum interval of the last seizure episode occurring 1 week before observation. More than half of the patients (60.4%) had abnormal EEGs. Most patients were treated with monotherapy AED (81.3%). Seventy five percent of patients had low quality of life and 47.9% had sleep disturbances. In multivariate analysis, adolescents with abnormal initial diagnosis EEGs had 19.1 times higher risk of sleep disturbances (95%CI 3.3 to 110.4 P= 0.001) than those with normal EEGs. Among patients with abnormal EEGs, sleep disturbances increase the risk of low quality of life (OR 1.6; 95%CI 0.93 to 2.73; P=0.015) . Conclusion Abnormal EEG was a significant risk factor for sleep disturbances and low quality of life in adolescent epilepsy patients.
Hubungan Jenis, Jumlah, dan Lama Pemberian Obat Anti Epilepsi dengan Kadar 25-Hidroksi Vitamin D pada Anak Epilepsi Wijaya, Aji Kristianto; Salendu, Praevilia Margareth; Mandei, Jose Meky
Sari Pediatri Vol 25, No 5 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.5.2024.328-32

Abstract

Latar belakang. Penggunaan obat anti epilepsi diduga dapat menyebabkan defisiensi vitamin D.Tujuan. Mengetahui adanya hubungan jenis, jumlah, dan lama pemberian obat anti epilepsi terhadap kadar 25-hidroksi vitamin D pada anak epilepsi.Metode. Penelitian observasional analitik secara potong lintang pada anak epilepsi usia 7 bulan-18 tahun di poli neurologi anak RSUP Prof. R. D. Kandou Manado antara 1 Agustus 2022 - 31 Desember 2022. Hasil. Dari total 66 anak epilepsi ditemukan 19 anak defisiensi vitamin D (28,8%), 20 anak insufisiensi (30,3%), dan 27 anak status vitamin D normal (40,9%). Anak yang mendapat obat asam valproat, fenitoin, dan karbamazepin memiliki kadar 25(OH)D sebesar 27,66 (15,45 – 58,10), 25,17 (21,44 – 33,50), dan 29,49 (17,89 – 41,10) dengan nilai p = 0,991. Anak yang mendapat pengobatan monoterapi memiliki kadar 25(OH)D lebih tinggi yaitu 28,09 (16,20 – 58,10) dibandingkan pengobatan politerapi yaitu 18,94 (15,45 – 35,10) dengan nilai p=0,036. Lama pemberian obat monoterapi dan politerapi dengan kadar 25(OH)D diperoleh nilai signifikansi sebesar 0,000 (sig < 0.05) dengan koefisien korelasi sebesar -0,528 (0,41 – 0,60). Kesimpulan. Tidak terdapat hubungan antara jenis OAE dengan kadar vitamin D. Terdapat hubungan antara jumlah OAE dan lama pemberian OAE dengan kadar vitamin D.
Co-Authors Aji Kristianto Wijaya Jose Meky Mandei, Jose Meky Manurung, Elsa Ameliana