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All Journal Jurnal Penyakit Dalam Indonesia Jurnal Muara Medika dan Psikologi Klinis
Diahtantri, Riyanti Astrid
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Health Professions Medicine & Pharmacology Neuroscience

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The Association between D-dimer Concentration and Laboratory Parameters for Plasma Leakage in Dengue Infection Suwarto, Suhendro; Diahtantri, Riyanti Astrid; Hudiya, Elian
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 3
Publisher : UI Scholars Hub

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Abstract

Introduction. Plasma leakage and activation of the coagulation system are the pathological hallmark of dengue hemorrhagic fever (DHF) that causes an increase in D-dimer concentration due to the degradation of fibrin clots. This study was conducted to determine the association between of D-dimer and laboratory parameters of plasma leakage, namely: thrombocytopenia, hypoalbuminemia, hemoconcentration and concentration serum glutamic oxaloacetic transaminase (SGOT) in dengue infected patients. Methods. A retrospective study was conducted at private hospitals in Jakarta, from December 2016 to March 2018. Patients >14 years with dengue infection and positive NS-1 were included in this study, and were classified into dengue fever (DF) group or DHF group. The Mann Whitney test was used for non-parametric variables and the Spearman test was used for the correlation for non-normally distributed numeric variables. Results. Seventy-three dengue infected patients included in this study consists of 29 (39.7%) female and 44 (60.3%) male. Total of 43 (58.9%) were classified as DD group, 30 (41.1%) were classified as DHF group. The D-dimer concentration of the DHF group in the fever phase was higher compared to the DD group (p = 0.004). There was a weak correlation in the fever phase between D-dimer concentration and the degree of thrombocytopenia (r = 0.35; p = 0.003) and weak inverse correlation in the fever phase between D-dimer concentration and albumin concentration (r = -0.34; p = 0.049). We found a weak correlation in the critical phase between D-dimer concentration and the degree of thrombocytopenia (r = 0.39; p = 0.034) and the moderate inverse correlation in the critical phase between the D-dimer concentration and albumin concentration (r = -0.43; p = 0.032). Conclusions. D-dimer concentrations in DHF patients in the fever phase are higher compare to DD patients. D-dimer concentration correlates with the degree of thrombocytopenia and hypoalbuminemia.
PERAN TERAPI ANTIOKSIDAN PADA MELASMA Diahtantri, Riyanti Astrid; Mughni, Fadhli Aulia; Menaldi, Sri Linuwih
Jurnal Muara Medika dan Psikologi Klinis Vol. 4 No. 1 (2024): Jurnal Muara Medika dan Psikologi Klinis
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jmmpk.v4i1.34338

Abstract

Melasma adalah penyakit hiperpigmentasi pada kulit yang terpajan sinar matahari dan dapat bersifat kronik rekuren. Penyebab pasti melasma belum diketahui akan tetapi spesies oksigen reaktif (ROS) akibat pajanan sinar ultraviolet (UV) diduga berperan dalam patogenesis melasma. Mekanisme pertahanan terhadap toksisitas ROS mencakup antioksidan enzimatik, yang terdiri atas katalase, superoksida dismutase (SOD), dan glutation peroksidase, serta antioksidan non-enzimatik. Dalam tulisan ini akan dijelaskan jenis-jenis ROS, antioksidan, dan stres oksidatif serta pengobatan melasma yang berhubungan dengan penggunaan antioksidan untuk menetralisir efek stres oksidatif.
Co-Authors Hudiya, Elian Mughni, Fadhli Aulia Sri L. Menaldi Suhendro Suwarto, Suhendro