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All Journal The Journal of Experimental Life Sciences (JELS) Biotropika
Shofiyah, Aya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Expression of IL-17 on Breast Cancer Mice Treated by Combination of Phyllanthus Urinaria and Catharanthus roseus Extract Shofiyah, Aya; M. Sasmito Djati; Muhaimin Rifa'i
The Journal of Experimental Life Science Vol. 12 No. 2 (2022)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2022.012.02.05

Abstract

This study aimed to evaluate the effect of combination Phyllanthus urinaria and Catharanthus roseus in breast cancer mice based on the expression of IL-17. 7,12-Dimethylbenz(α)anthracene (DMBA) was injected intraperitoneally into normal mice at dose 1.5 mg.kg-1 weight to obtain breast cancer mice. Total of 24 experimental mice divided into normal mice (N), breast cancer mice (K), breast cancer mice with cisplatin (C) treatment (5 mg.kg-1 weight), breast cancer mice with combination extract Dose 1 (P. urinaria 500 mg.kg-1 weigt + C. roseus 15mg.kg-1 weight), breast cancer mice with combination extract Dose 2 (P. urinaria 1000 mg.kg-1 weight + C. roseus 75mg.kg-1 weight), and breast cancer with combination extract Dose 3 (P. urinaria 2000 mg.kg-1 weight + C. roseus 375 mg.kg-1 weight). Cheral was given orally for 14 days. The level of IL-17 was evaluated by flow cytometry analysis. The combination can suppress the expression of IL-17 which down regulation of IL-17 indicate a good prognosis for the breast cancer mice, for 6.17% in breast cancer condition to 0.93% with Dose 3 treatment. The combination can be used as immunomodulatory agent in humoral immunity through the regulation of IL-17. Keywords: Breast cancer, Catharanthus roseus, IL-17, Phyllanthus urinaria
Expression of IL-6 on Breast Cancer Mice Treated by Combination of Phyllanthus Urinaria and Catharanthus roseus Extract Shofiyah, aya; Djati, Mohammad Sasmito; Rifa'i, Muhaimin
Biotropika: Journal of Tropical Biology Vol. 10 No. 2 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.02.03

Abstract

Breast cancer is one kind of cancer that can cause the death in women. Although, many kind of treatment have done to suppress the growth of breast cancer case, but the number of case still increased. Chemotherphy is one kind of treatment used to suppress breast cancer case. But it is known that can give many poor effect. So it need to get an alternative treatment such as using a herbal plant as medicine as Phyllanthus urinaria and Catharanthus roseus. This research aimed to study the effect of Phyllanthus urinaria and Catharanthus roseus on IL-6 expressed by CD11bin breast cancer model.this research using RAL divided into 6 group as Normal group (N), cancer group (K), Cisplatin treatment (C), Dose 1 (D1) (Phyllanthus urinaria 500 mg/kg weight and Catharanthus roseus 15 mg/kg weight), dose 2 (D2) (Phyllanthus urinaria 1000 mg/kg weight and Catharanthus roseus 75 mg/kg weight) and dose 3 (D3) (Phyllanthus urinaria 2000 mg/kg weight and Catharanthus roseus 375 mg/kg weight).  the mice had inject by DMBA in 0,015 mg/kg weight in six week. The combination of Phyllanthus urinaria and Catharanthus roseus were administrated orally in two weeks. The expression of IL-6 expressed by CD11b ws analysed by flow cytometry. Data analysed by SPPSS in one way ANOVA and tukey test. Based on result, it showed that dose 3 is the optimal dose to suppress the growth of cancer cells based on IL-6 expression. All of the dose used can suppress the growth of IL-6.   Keywords: Breast cancer, Catharanthus roseus, IL-6, machrophage, Phyllanthus urinaria
Co-Authors Djati, Mohammad Sasmito Moch Sasmito Djati Muhaimin Rifa'i Rifa'i, Muhaimin