Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Science and Technology Indonesia Communications in Science and Technology
Roswanda, Robby
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Engineering Environmental Science Materials Science & Nanotechnology Physics

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Discovery of thymol-fused chalcones as new competitive \(\alpha\)-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies Danova, Ade; Hermawati, Elvira; Chavasiri, Warinthorn; Mujahidin, Didin; Alni, Anita; Roswanda, Robby
Communications in Science and Technology Vol 9 No 2 (2024)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.9.2.2024.1497

Abstract

This study aims to synthesize and evaluate the inhibitory activity of thymol derivatives targeting ?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) including five new thymol-fused chalcones (7-11) were successfully synthesized. Among them, four compounds (4, 8, 9, 11) showed the best inhibitory activity with IC50 values of 18.45, 13.75, 8.86, and 10.67µM compared with acarbose (IC50 = 832.82 µM), respectively. The kinetic study of three new thymol-fused chalcones (8, 9, 11) exhibited a competitive inhibition. Molecular docking demonstrated the predicted interactions between ligand (8, 9, 11) and ?-glucosidase, which are responsible for inhibiting the enzyme's catalytic abilities. Furthermore, molecular dynamics simulation of the enzyme-ligand 9 complex indicated that this complex was stable in aqueous condition. This research contributes significantly to the understanding of thymol-fused chalcones that may have therapeutic potential and their possible application in the treatment of type 2 diabetes mellitus (T2DM) for further study.
Intramolecular Oxa-Michael Cyclization of 2’-Hydroxychalcones for the Synthesis of Flavanones: A Comparative Study Ramadhini, Rizky Annisa; Danova, Ade; Roswanda, Robby
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1169-1178

Abstract

In this study, flavanones were synthesized using a two-step reaction process starting from 2’ hydroxyacetophenone and aldehydes. Claisen-Schmidt condensations were carried out on the starting materials to produce 2’-hydroxychalcones with mono-, di-, and tri-substituents on ring B. Subsequently, flavanones were produced via intramolecular oxa-Michael cyclization under three different reaction conditions: methanesulfonic acid in ethanol, sodium acetate in methanol, and piperidine in water. These approaches aimed to investigate the steric and electronic effects to achieve high yields in optimal reaction conditions for flavanone synthesis. Twelve 2’-hydroxychalcones (1a-1l) were successfully synthesized with yields ranging from 17% to 99%. The use of methanesulfonic acid in ethanol resulted in modest flavanone yields (11% for 2a, 13% for 2c). The synthesis of flavanones using sodium acetate was successful for seven 2’-hydroxychalcones (2a-2g), yielding products with varying yields (2-49%). Furthermore, piperidine was effective for three 2’-hydroxychalcones (1a, 1b, 1e), resulting in high flavanone yields (74-93%). These findings indicate that the three reaction conditions are only effective for certain 2’-hydroxychalcones.
Co-Authors Ade Danova Anita Alni, Anita Chavasiri, Warinthorn Didin Mujahidin Hermawati, Elvira Ramadhini, Rizky Annisa