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All Journal Jurnal Sains Teh dan Kina Communications in Science and Technology Jurnal Kartika Kimia JKPK (Jurnal Kimia dan Pendidikan Kimia)
Anita Alni, Anita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Engineering Environmental Science Industrial & Manufacturing Engineering Mechanical Engineering

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The oxidation reaction of quinine by potassium permanganate (KMnO4) Rosalina, Reny; Alni, Anita; Mujahidin, Didin; Santoso, Joko
Jurnal Penelitian Teh dan Kina Vol 18, No 2 (2015)
Publisher : Research Institute for Tea and Cinchona

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.892 KB) | DOI: 10.22302/pptk.jur.jptk.v18i2.76

Abstract

Quinine was known widely as malarial drug and a bitter taste ini soft drink. Recently, quinine have been also applied in organo-catalysis process, separation and purification of chiral compounds from enantiomeric mixture by diasteromeric salt crystallization and chiral chromatography. Quinine contains various functional groups which easily transforms by oxidations. This research was to study the oxi-dation reaction of quinine by using potassium permanganate (KMnO4) as oxidator. The KMnO4 oxidation carried out under acidic con-ditions. The separation and purification of pro-ducts were done by radial chromatography with chloroform : metanol : tri ethyl amine (9:1:0.1) as eluent. The structure of products were cha-racterized by spectroscopic data including: in-frared spectroscopy, NMR, and mass spectro-metry as quinine-1-N-oxide and quininal.
Sintesis dan Karakterisasi Titanium Oksida Dalam Cairan Ion 1-Butil-3-Metil Imidazolium Klorida dengan Metode Hidrotermal Enriyani, Riri; Zulfikar, Muhammad Ali; Alni, Anita
Jurnal Kartika Kimia Vol 5 No 1 (2022): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v5i1.111

Abstract

In this study, TiO2 was synthesized using the hydrothermal method which the solvent used was a mixture of 1-butyl-3-methyl imidazolium chloride ion (BMIM Cl) with water in a ratio of 3:7 v/v. Ionic liquid of 1-butyl-3-methyl imidazole was synthesized with methyl imidazole and chlorobutane as precursors and then characterized using 43 MHz NMR. TiO2 which had been synthesized with BMIM Cl : water (3:7 v/v) was then characterized using XRD, SEM, UV-Vis/DR and BET then compared the results with TiO2 synthesized with water solvent. Based on of XRD analysis was obtained that TiO2 was synthesized by BMIM Cl : water (3:7 v/v) and water solvent produced anatase and brochite crystals where the crystal size of TiO2 synthesized with BMIM Cl : water (3:7 v/v) as solvent was smaller that is 17.70 nm and which is synthesized with water solvent is about 20.35 nm. Based on the SEM characterization data, the morphological structure was more homogeneous. Based on the characterization data using UV-Vis/DR and BET, it was obtained that TiO2 synthesized with BMIM Cl : water (3:7 v/v) had a bigger band gap and larger surface area and pores than TiO2 synthesized by water solvent.
Optimization of Nitration of 3-Hydroxypyrazine-2-Carboxamide to 3-Hydroxy-6-Nitropyrazine-2-Carboxamide Setyowati, Widiastuti Agustina Eko; Ihsanawati, Ihsanawati; Alni, Anita
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 8, No 3 (2023): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v8i3.81987

Abstract

This study focuses on optimizing the synthesis of 3-hydroxy-6-nitropyrazine-2-carboxamide, a critical intermediate in producing various pyrazine-based pharmaceuticals. The compound is synthesized through the nitration of 3-hydroxypyrazine-2-carboxamide, employing sulfuric acid (H2SO4) and potassium nitrate (KNO3) as reagents. The research aimed to refine the synthesis process to enhance yield purity for pharmaceutical applications. The optimization entailed adjusting the reagents' composition and solvents, specifically the ratio of substrate to KNO3, the volume of H2SO4 used per gram of substrate, and the temperatures for both the reaction and product precipitation. Optimal results were observed at a substrate-to-KNO3 ratio of 1:2, with 12 mL of H2SO4 per gram of substrate. The reaction temperature was set at 50°, and precipitation occurred effectively at 0°C. This optimized method significantly improved the yield and purity of the compound. The process demonstrated excellent repeatability, with yields ranging from 77% to 80%, a considerable increase from the 48% yield reported in previous studies. The molecular structure of the synthesized compound was confirmed through comprehensive spectroscopic analyses, including 1H NMR, 13C NMR, and High-Resolution Electrospray Ionization Time-of-Flight Mass Spectrometry (HRESI-TOF-MS). This research represents a significant advancement in synthesizing 3-hydroxy-6-nitropyrazine-2-carboxamide, offering a more efficient and reliable method for producing this key pharmaceutical intermediate. The improved synthesis process ensures higher yields and maintains the purity required for pharmaceutical applications, thereby contributing to the efficient development of pyrazine-based drug compounds.
Discovery of thymol-fused chalcones as new competitive \(\alpha\)-glucosidase inhibitors: Design, synthesis, biological evaluation, and molecular modeling studies Danova, Ade; Hermawati, Elvira; Chavasiri, Warinthorn; Mujahidin, Didin; Alni, Anita; Roswanda, Robby
Communications in Science and Technology Vol 9 No 2 (2024)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.9.2.2024.1497

Abstract

This study aims to synthesize and evaluate the inhibitory activity of thymol derivatives targeting ?-glucosidase using in vitro and in silico studies. Ten thymol derivatives (2-11) including five new thymol-fused chalcones (7-11) were successfully synthesized. Among them, four compounds (4, 8, 9, 11) showed the best inhibitory activity with IC50 values of 18.45, 13.75, 8.86, and 10.67µM compared with acarbose (IC50 = 832.82 µM), respectively. The kinetic study of three new thymol-fused chalcones (8, 9, 11) exhibited a competitive inhibition. Molecular docking demonstrated the predicted interactions between ligand (8, 9, 11) and ?-glucosidase, which are responsible for inhibiting the enzyme's catalytic abilities. Furthermore, molecular dynamics simulation of the enzyme-ligand 9 complex indicated that this complex was stable in aqueous condition. This research contributes significantly to the understanding of thymol-fused chalcones that may have therapeutic potential and their possible application in the treatment of type 2 diabetes mellitus (T2DM) for further study.
Synthesis of Vinyl Modified Silica as a High-Performance Liquid Chromatography Stationary Phase Alzena, Ardine Zada; Rusli, Handajaya; Alni, Anita; Amran, Muhamad Bachri
Jurnal Kartika Kimia Vol 8 No 1 (2025): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v8i1.893

Abstract

Silica can be produced through hydrolysis in alkaline conditions via the Stober process and has two main functional groups, namely siloxane (Si-O-Si) and silanol (Si-OH). Vinyl modified silica can be produced from the hydrolysis of tetraethyl orthosilicate (TEOS) and vinyl trimethoxysilane (VTMS) with 25%(v/v) ammonia. VTMS is used as a silica surface modifying agent. The resulting silica-vinyl modification is then used as a stationary phase to fill a High Performance Liquid Chromatography (HPLC) column. The aim of this research is to synthesize vinyl-modified silica as a HPLC stationary phase and test its performance. Silica-vinyl modification is carried out by first synthesizing silica from TEOS and then modifying the surface using VTMS. Characterization was carried out using a Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). SEM characterization gave a spherical shape and a diameter of 1.73-2.02 μm. FTIR identification gave good results with the identification of siloxane signals (Si-O-Si) at 1,097 cm-1 on silica and 2,850 cm-1 and 2,922 cm-1 which were C-H vibrations on silica-vinyl. Qualitative identification carried out by the addition of alkenes with I2 also shows the binding of vinyl groups to the silica surface. The modified silica is then loaded into a 50 mm x 4.6 mm column. The performance test was carried out by separating caffeine and paracetamol compounds. Optimum separation of MeOH:HOH 1:99 eluent with a flow rate of 1 mL/min. The resulting resolution is 1,80 and selectivity is 1.52. The resulting calibration curve has an R2 value of 0.99156 for caffeine and 0.99431 for paracetamol.
Co-Authors Ade Danova Alzena, Ardine Zada Chavasiri, Warinthorn Didin Mujahidin Enriyani, Riri Handajaya Rusli, Handajaya Hermawati, Elvira IHSANAWATI IHSANAWATI Muhammad Ali Zulfikar Muhammad Bachri Amran Reny Rosalina Roswanda, Robby Setyowati, Widiastuti Agustina Eko Siti Zubaidah