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All Journal Jurnal Ilmu Kefarmasian Indonesia Medical and Health Science Journal
Dewi, Lestari
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Social Sciences

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EFFECT OF ASIATIC MANGROVE (RHIZOPHORA MICRONATA) LEAVES EXTRACT AS ANALGESIC IN MALE ALBINO DDW MICE (MUS MUSCULUS L.) INDUCED BY 0,7% ACETIC ACID Nanuru, Erika Widianingsih; Dewi, Lestari; Wibowo, Prajogo
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 2 (2021): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i2.2313

Abstract

Background : Pain is an unpleasant emotional experience that illustrates ongoing tissue damage. Excessive use of non-steroidal anti-inflammatory drugs can cause peptic ulcer to gastric mucosal damage and perforation. Indonesia contains the largest area of mangrove forest in the world. There are 45 species of mangrove found and one of them is Asiatic Mangrove (Rhizophora mucronata). This type is easy to find and rich of alkaloids and flavonoids which can be used as analgesics. Method:  This study used post-test only control group design. The number of mice that used was 25 mice, divided into 5 groups. Which were given different therapies aquadest 10mL/KgBW, acetosal 150 mg/KgBW, extract of Rhizophora mucronata 250 mg/KgBW, 500 mg/KgBW, and 1000 mg/kg bw. The pain was induced by 0,7% glacial acetic acid at a dose of 10 mL/KgBW.  The writhes of the mice was being calculated with an interval of 10 minutes in 30 minutes. Result:  The results of the analysis showed the decrease in writhes of mice  in acetosal group dose 150 mg/kg bw, Rhizophora mucronata leaves extract dose 250 mg/kg bw, 500 mg/kg bw, and 1000 mg/kg bw. There was a significant difference in the results of the Mann-Whitney U test with p<0,05 in the aquadest group and the acetosal group with the Rhizophora mucronata leaves extract group dose 500 mg/kg bw, the difference between the acetosal group and the Rhizophora mucronata leaves extract group dose 250 mg/kg bw, and the difference between the Rhizophora mucronata leaves extract group dose 500 mg/kg bw and the Rhizophora mucronata leaves extract group dose 1000 mg/kg bw. Conclusion: Rhizophora mucronata leaves extract dose 500 mg/kg bw can provide analgesic effect and can reduce the writhing frequency in mice much better than acetosal group.
Effect of Stichopus hermanii extract on interleukin-6 levels in a high-fat diet-induced rat model of inflammation Purwaningsari, Diah; Tehupuring, Sihning Endah J.; Pranitasari, Nita; Dewi, Lestari
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI In Press
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.2030

Abstract

Atherosclerosis is a major contributor to cardiovascular diseases and is increasingly recognized as a chronic low-grade inflammatory disorder involving oxidative stress and immune-mediated mechanisms. Interleukin-6 (IL-6) is a key proinflammatory cytokine that links oxidative stress and immune responses and has been widely associated with the progression of inflammation-related vascular conditions and the acceleration of atherosclerosis. The adverse effects of current pharmaceuticals have driven interest in herbal alternatives with fewer side effects. Sea cucumbers are recognized as potent biomedical resources with bioactivities against atherosclerotic pathways. This study aimed to identify the effects of Stichopus hermanii extract on IL-6 levels in a rat model of atherosclerosis induced by a high-fat diet. An experimental in vivo study utilizing a post-test-only control group design was performed on 32 Wistar rats, categorized into four groups: negative control (standard diet), positive control (high-fat diet), and two treatment groups administered Stichopus hermanii extract at dosages of 35 mg and 40 mg per 200 g body weight. IL-6 concentrations were markedly increased in rats subjected to a high-fat diet compared to those in the conventional diet group (p<0.05). Stichopus hermanii extract at both dosages markedly diminished IL-6 concentrations compared to the positive control group. The 40 mg dose reinstated IL-6 levels to those similar to the negative control group, signifying a dose-dependent anti-inflammatory effect. The extract of Stichopus hermanii successfully regulated IL-6 levels in rats with atherosclerosis induced by a high-fat diet, indicating its potential as a natural anti-inflammatory and cardioprotective agent for managing atherosclerosis.
Co-Authors Diah Purwaningsari Nanuru, Erika Widianingsih Pranitasari, Nita Tehupuring, Sihning Endah J. Wibowo, Prajogo