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PENGARUH EKSTRAK DAUN PEPAYA (Carica papaya) TERHADAP KEMATIAN LARVA NYAMUK Aedes agypti INSTAR III Payangka, Jonathan; Risma, Risma; Wibowo, Prajogo
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i1.921

Background: Papaya leaves (Carica papaya) extract is a natural larvacide that contains papain and alkaloid karpain so its usage is safe for the environment. The larvacide properties can also be used to reduce the amount of Aedes aegypti mosquito larvae. This mosquito species is the main vector for the virus that causes dengue fever which incident number increases over the years. There have been a few methods used to control the mosquito?s amount, one of which is by decreasing the number of Aedes aegypti?s larvae using the organophosphate insecticide chemical known as temefos. Temefos is really effective in killing the Aedes aegypti larvae but it has a lot of side effects especially towards the environment. By controlling the number of the Aedes aegypti?s larvae, hopefully the number of the dengue fever case can also be reduced. Objective: To prove that the papaya leaves (Carica papaya) extract have effects on the death of Aedes aegypti?s instar III larvae. Method: This is an experimental research what uses a post test only control group design. The study consists of seven groups, which are positive control that is given abate powder, negative control that is given only aquadest, and five groups treated with concentrations of 0.5%, 1%, 1.5%, 2%, and 2.5%; repeated for four times. The calculation of the amount of dead larvae is done within the first 24 hours. Result: Based on the Kruskal-Wallis test, p?s value is <? with p value being 0.000 and ? being 0.05. It proves the significance of the experiment. Conclusion: The papaya leaves (Carica papaya) extract have effects on the death of Aedes aegypti?s instar III larvae

EFEK QUERCETIN DARI BUAH DELIMA (PUNICA GRANATUM L.) TERHADAP PENURUNAN GLUKOSA DARAH Barkha Agung Priyanto; Prajogo Wibowo
Surabaya Biomedical Journal Vol 1 No 1 (2021): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i1.9

Delima (Punica granatum L.) lebih dikenal di beberapa negara sebagai buah Eden, karena rasanya yang enak dan khasiatnya yang bermanfaat bagi kesehatan. Buah delima dan ekstrak buah delima telah terbukti memiliki aktivitas pencegahan dan penghambatan terhadap berbagai penyakit kronis dan mengancam kesehatan atau kehidupan. Diabetes tipe 2 dapat dicegah dan di obati dengan senyawa quercetin.Quercetin merupakan flavonoid paling popular yang banyak terkandung dalam sayuran dan buah-buahan.Flavonoid signifikan menurunkan kadar gula darah, meningkatkan ekspresi GLUT4, dan memperkuat penyerapan glukosa pada permukaan sel otot tulang dengan menstimulasi Adenosin Monofosfat Protein Kinase (AMPK). Untuk mengetahui efek pemberian quercetin terhadap penurunan kadar glukosa dalam darah pada pasien diabetes melitus tipe 2. Penelitian ini menggunakan desain penelitian deskriptif dengan metode studi literatur minimal 15 artikel dari jurnal nasional yang terindeksSINTA dan jurnal internasional yang terindeks Scimago dengan batasan tahun 2015-2020. Kandungan flavonoid dari quercetin memiliki efek pada pasien diabetes melitus tipe 2 dengan menjadi ligan yang mampu memperbaiki reseptor (AMPK, GLUT 4, SIRT1, nuclear factor kappa (NF-kB)) sehingga dapat mengendalikan gen sel adiposa atau transkripsi lainnya yang memengaruhi resistensi insulin pada pasien diabetes tipe 2. Kesimpulan yang saya dapatkan dari hasil penelitian studi literature ini adalah quercetin dapat mempengaruhi dalam penurunan kadar glukosa dalam darah.

A Case Report :Alprazolam Therapy in A Dextra Fronto-Parietal Meningioma Patient With Anxiety Disorders: Efektivitas Alprazolam Pada Pasien Meningioma Fronto-Parietal Dextra Dengan Gangguan Cemas Wibowo, Prajogo; Utami, Prawesty Diah
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 4 No. 1 (2021): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v4i1.1409

Meningiomas in the frontoparietal lobe may cause anxiety disorders and panic attacks. While alprazolam is one of the most widely used medications for anxiety disorders, long-term use may result in adverse side effects (withdrawal and rebound effects). This case study aims to describe the efficacy of long-term alprazolam administration in patients with meningiomas for regulating anxiety disorders. Case report :The asymmetrical face is the primary concern of a 65-year-old female when she is anxious. The results of the physical assessment and laboratory tests are within normal ranges. However, The HARS procedure showed moderate anxiety, and the CT scan revealed a meningioma in the right frontoparietal lobe. To regulate patient anxiety disorders, doctors give alprazolam 0.5 mg per day single dose for 4 months and tapering off for 3 months. Conclusion: Long-term administration of alprazolam in these patients can reduce the patient's anxiety disorder without causing withdrawal or rebound effects. A low dosage of alprazolam, a mild level of anxiety illness, and a slow tapering off phase were factors that contributed to the effectiveness of alprazolam treatment to suppress anxiety symptoms in this situation.

PENGARUH EKSTRAK DAUN PEPAYA (Carica papaya) TERHADAP KEMATIAN LARVA NYAMUK Aedes agypti INSTAR III Payangka, Jonathan; Risma, Risma; Wibowo, Prajogo
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i1.921

Background: Papaya leaves (Carica papaya) extract is a natural larvacide that contains papain and alkaloid karpain so its usage is safe for the environment. The larvacide properties can also be used to reduce the amount of Aedes aegypti mosquito larvae. This mosquito species is the main vector for the virus that causes dengue fever which incident number increases over the years. There have been a few methods used to control the mosquito’s amount, one of which is by decreasing the number of Aedes aegypti’s larvae using the organophosphate insecticide chemical known as temefos. Temefos is really effective in killing the Aedes aegypti larvae but it has a lot of side effects especially towards the environment. By controlling the number of the Aedes aegypti’s larvae, hopefully the number of the dengue fever case can also be reduced. Objective: To prove that the papaya leaves (Carica papaya) extract have effects on the death of Aedes aegypti’s instar III larvae. Method: This is an experimental research what uses a post test only control group design. The study consists of seven groups, which are positive control that is given abate powder, negative control that is given only aquadest, and five groups treated with concentrations of 0.5%, 1%, 1.5%, 2%, and 2.5%; repeated for four times. The calculation of the amount of dead larvae is done within the first 24 hours. Result: Based on the Kruskal-Wallis test, p’s value is <α with p value being 0.000 and α being 0.05. It proves the significance of the experiment. Conclusion: The papaya leaves (Carica papaya) extract have effects on the death of Aedes aegypti’s instar III larvae

EFFECT OF ASIATIC MANGROVE (RHIZOPHORA MICRONATA) LEAVES EXTRACT AS ANALGESIC IN MALE ALBINO DDW MICE (MUS MUSCULUS L.) INDUCED BY 0,7% ACETIC ACID Nanuru, Erika Widianingsih; Dewi, Lestari; Wibowo, Prajogo
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 2 (2021): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i2.2313

Background : Pain is an unpleasant emotional experience that illustrates ongoing tissue damage. Excessive use of non-steroidal anti-inflammatory drugs can cause peptic ulcer to gastric mucosal damage and perforation. Indonesia contains the largest area of mangrove forest in the world. There are 45 species of mangrove found and one of them is Asiatic Mangrove (Rhizophora mucronata). This type is easy to find and rich of alkaloids and flavonoids which can be used as analgesics. Method: This study used post-test only control group design. The number of mice that used was 25 mice, divided into 5 groups. Which were given different therapies aquadest 10mL/KgBW, acetosal 150 mg/KgBW, extract of Rhizophora mucronata 250 mg/KgBW, 500 mg/KgBW, and 1000 mg/kg bw. The pain was induced by 0,7% glacial acetic acid at a dose of 10 mL/KgBW. The writhes of the mice was being calculated with an interval of 10 minutes in 30 minutes. Result: The results of the analysis showed the decrease in writhes of mice in acetosal group dose 150 mg/kg bw, Rhizophora mucronata leaves extract dose 250 mg/kg bw, 500 mg/kg bw, and 1000 mg/kg bw. There was a significant difference in the results of the Mann-Whitney U test with p<0,05 in the aquadest group and the acetosal group with the Rhizophora mucronata leaves extract group dose 500 mg/kg bw, the difference between the acetosal group and the Rhizophora mucronata leaves extract group dose 250 mg/kg bw, and the difference between the Rhizophora mucronata leaves extract group dose 500 mg/kg bw and the Rhizophora mucronata leaves extract group dose 1000 mg/kg bw. Conclusion: Rhizophora mucronata leaves extract dose 500 mg/kg bw can provide analgesic effect and can reduce the writhing frequency in mice much better than acetosal group.

The Correlation between Visual, Auditory, and Kinesthetic Learning Styles with SOOCA Examination Scores in Students of the Faculty of Medicine, Hang Tuah University, Surabaya Vijaya, Ailya Tefanya; Wibowo, Prajogo; Mutiadesi, Wahyu Prasasti; Handajani, Fitri
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 3 (2023): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i3.116

Learning style is one way that someone chooses to understand the material more quickly and easily. Everyone needs to identify their learning style in order to determine the most efficient learning method according to their characteristics. There are three kinds of learning styles, namely visual, auditory, and kinesthetic learning styles. Every student has a basis for this learning style, but not all of them develop proportionally, but some become dominant. This research was conducted to determine the relationship between the three learning styles and sooca exam scores in students of the Faculty of Medicine, Hang Tuah University, Surabaya. This research uses quantitative methods. The population in this study were all pre-clinical students in semesters 2, 4, 6 with active student status at the Faculty of Medicine, Hang Tuah University, Surabaya who took the SOOCA (structure Objective Oral Examination) exam and were willing to fill out the questionnaire in the period of June to December 2022. The sample size was obtained in the time period is 86 respondents. The results showed that out of 86 respondents, 3 (3.5%) were 18 year old students, 10 (11.6%) were 19 year old students, 26 (30.2%) were 20 year old students, 39 (45.4%) ) students aged 21 years, 8 (9.3%) students aged 22 years. A total of 64 (74.4%) respondents were female, and 22 (25.6%) respondents were male. 13 (15.1%) respondents have a visual learning style, 13 (15.1%) respondents have an auditory learning style, and 60 (69.8%) respondents have a kinesthetic learning style. Conclusion of this study is that there is no relationship between Visual, Auditorial, and Kinesthetic Learning Styles with Sooca Examination Scores in students of the Faculty of Medicine, Hang Tuah University, Surabaya. The learning styles of the students of the Faculty of Medicine, Hang Tuah University, Surabaya, class of 2018, 2019 and 2020, mostly have a kinesthetic learning style.

Characteristics of Chronic Kidney Disease Patients Undergoing Hemodialysis at RSPAL Dr. Ramelan Surabaya from January to June 2022 Carolina, Anita; Wibowo, Prajogo; Prameswari, Renata
Jurnal Ilmiah Kesehatan Vol 17 No 03 (2024): Jurnal Ilmiah Kesehatan (Journal of Health Science)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v17i03.4599

Chronic Kidney Disease (CKD) is a persistent abnormality in kidney function or structure, with or without a decline in glomerular filtration rate (GFR) below 60 mL/min/1.73 m², lasting for more than three months. CKD diagnosis relies on markers of kidney damage and/or a reduction in GFR. Patients with advanced CKD, characterized by a GFR below 15 mL/min/1.73 m², typically require dialysis. In 2018, 60,852 individuals in Indonesia were reported to have CKD requiring lifelong dialysis. This study aims to assess the characteristics of CKD patients undergoing hemodialysis. This research employs descriptive design. The sample consists of all CKD patients undergoing hemodialysis, as recorded in the medical records of RSPAL dr. Ramelan Surabaya between January and June 2022. The findings reveal that more than half of the patients (52.7%) had been on hemodialysis for more than 12 months. Many of the patients (66.2%) were between 40 and 60 years old, with males accounting for 54.1% of the sample. Hypertension and diabetes mellitus were identified as the most common comorbid conditions (31.1%), while pain medication consumption was the least reported cause (2.7%). All patients had hemoglobin levels below the normal range (<13 g/dL for males and <12 g/dL for females) and relied on BPJS (Indonesia’s national health insurance) to cover the cost of hemodialysis. Furthermore, most patients exhibited creatinine levels exceeding 1.5 mg/dL, blood urea nitrogen (BUN) levels above 24 mg/dL, serum iron (SI) levels between 45 and 158 µg/dL, and total iron-binding capacity (TIBC) levels below 250 µg/dL.

Systemic Immune-Inflammation Index (SII) and NeutrophilLymphocyte Ratio (NLR) as a Promising Predictor for Advanced Stage Events during the Follow-Up Period in Hepato-Gastrointestinal Cancer Patients Zenjaya, Kellyn Trycia; Biutifasari, Verna; Yudadi, Redemptus; Wibowo, Prajogo
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1186

Background: Tumor microenvironment has shown the role of inflammation in its progressivity. The heterogeneity of prognosis at the same TNM stage makes it difficult to classify patients who are more at risk of developing advanced stages. This study aimed to provide a deeper insight into the potential of cheap inflammation markers based on the Systemic ImmuneInflammation Index (SII) and Neutrophil-Lymphocyte Ratio (NLR) to predict the advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer.Methods: Case-control research was conducted using 120 data of patients with hepatogastrointestinal cancer (Colorectal cancer (CRC), hepatocellular carcinoma (HCC), gastrointestinal stromal tumor (GIST), esophageal adenocarcinoma (EAC), pancreatic ductal adenocarcinoma (PDAC), cholangio carcinoma (CCA)) taken from patient medical records. The patients were divided into case and control groups based on the presence of advanced stage events during the follow-up period that were further classified by the NLR and SII value. The advanced-stage events were analyzed and compared between the two groups using Chi-Square and logistic regression analysis to perceive the predictive value of each ratio. Results: Patients with advanced-stage hepato-gastrointestinal cancer had higher NLR and SII than patients without advanced stage (p 0.001). The group of patients with advanced stages had an average NLR of 18.45 and an SII of 6588.13. The group of patients without advanced stages had an average NLR of 5.12 and SII of 1545.01. The cut-off value was determined using the ROC curve, for NLR was 6.48 (92.5% sensitivity and 71.2% specificity), and for SII was 2264.24 (92.5% sensitivity and 76.2% specificity).Conclusions: NLR and SII are cheap markers and have considerable potential for predicting advanced stage during the follow-up period in patients with hepato-gastrointestinal cancer. SII is more accurate as a predictor than NLR. These tools can be very useful in identifying the high-risk patients among the same TNM stage.

Hubungan Personal Hygiene dengan Tingkat Kejadian Tinea di Rumah Susun Sumur Welut Tower D Surabaya Leksodimulyo, Marcella Clarineta; Chandra, Eka Narayana; Wibowo, Prajogo; Riami
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 5 No. 2 (2024): Oktober
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v5i2.209

Tinea (Dermatofitosis) adalah penyakit infeksi jamur yang disebabkan oleh jamur dermatofita yang menyerang jaringan berisi zat tanduk, misalnya kulit, rambut dan kuku. Berdasarkan lokasi infeksinya, Tinea dibagi menjadi Tinea capitis, Tinea faciei, Tinea barbae, Tinea corporis, Tinea Manuum, Tinea unguium, Tinea cruris, dan Tinea pedis. Penyakit Tinea di Indonesia cukup tinggi. Tinea dapat disebabkan oleh kontak langsung dengan orang terinfeksi, menggunakan pakaian yang ketat, personal hygiene yang buruk, kondisi lingkungan seperti kepadatan penduduk dan iklim yang lembab. Tujuan dari penelitian ini yaitu untuk mengetahui hubungan antara personal hygiene dengan tingkat kejadian Tinea pada Rumah Susun Sumur Welut Tower D di Surabaya. Penelitian ini merupakan penelitian analitik observasional. Sampel dalam penelitian merupakan 113 penghuni di Rumah Susun Sumur Welut Tower D. Pengambilan data menggunakan kuesioner dan pemeriksaan mikroskop dengan kerokan kulit. Analisis data menggunakan uji Kendall. Penelitian dilakukan pada bulan Agustus-September 2023 di Rumah Susun Sumur Welut Tower D Surabaya. Personal hygiene yang buruk sebanyak 13.3%. Angka kejadian Tinea Capitis 0.9%, Tinea Faciei 0.9%, Tinea Corporis 7.1%, Tinea Cruris 0.9%, Tinea Pedis 1.8%. Analisis Uji Kendall menunjukan terdapat hubungan antara personal hygiene dengan kejadian Tinea (p-Value 0.000). Terdapat hubungan antara personal hygiene dengan kejadian Tinea pada Rumah Susun Sumur Welut Tower D di Surabaya.

EFEK QUERCETIN DARI BUAH DELIMA (PUNICA GRANATUM L.) TERHADAP PENURUNAN GLUKOSA DARAH: 58-72 Priyanto, Barkha Agung; Wibowo, Prajogo
Surabaya Biomedical Journal Vol. 1 No. 1 (2021): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i1.9

Delima (Punica granatum L.) lebih dikenal di beberapa negara sebagai buah Eden, karena rasanya yang enak dan khasiatnya yang bermanfaat bagi kesehatan. Buah delima dan ekstrak buah delima telah terbukti memiliki aktivitas pencegahan dan penghambatan terhadap berbagai penyakit kronis dan mengancam kesehatan atau kehidupan. Diabetes tipe 2 dapat dicegah dan di obati dengan senyawa quercetin.Quercetin merupakan flavonoid paling popular yang banyak terkandung dalam sayuran dan buah-buahan.Flavonoid signifikan menurunkan kadar gula darah, meningkatkan ekspresi GLUT4, dan memperkuat penyerapan glukosa pada permukaan sel otot tulang dengan menstimulasi Adenosin Monofosfat Protein Kinase (AMPK). Untuk mengetahui efek pemberian quercetin terhadap penurunan kadar glukosa dalam darah pada pasien diabetes melitus tipe 2. Penelitian ini menggunakan desain penelitian deskriptif dengan metode studi literatur minimal 15 artikel dari jurnal nasional yang terindeksSINTA dan jurnal internasional yang terindeks Scimago dengan batasan tahun 2015-2020. Kandungan flavonoid dari quercetin memiliki efek pada pasien diabetes melitus tipe 2 dengan menjadi ligan yang mampu memperbaiki reseptor (AMPK, GLUT 4, SIRT1, nuclear factor kappa (NF-kB)) sehingga dapat mengendalikan gen sel adiposa atau transkripsi lainnya yang memengaruhi resistensi insulin pada pasien diabetes tipe 2. Kesimpulan yang saya dapatkan dari hasil penelitian studi literature ini adalah quercetin dapat mempengaruhi dalam penurunan kadar glukosa dalam darah.

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