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All Journal SENTRI: Jurnal Riset Ilmiah EJOIN : Jurnal Pengabdian Masyarakat Jurnal Farmasi dan Farmakoinformatika
Yulianto, Dwi Joko
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Aerospace Engineering Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Formulasi Krim Ekstrak Daun Johar (Cassia siamea Lamk.) Dengan Perbandingan Trietanolamin Dan Setil Alkohol Sebagai Antibakteri Staphylococcus aureus Puspitasary, Kiki; Murti, Rita Widiyasari; Novitasari, Meliana; Yulianto, Dwi Joko
Jurnal Farmasi dan Farmakoinformatika Vol 3, No 1 (2025)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2025.v3i1.11342

Abstract

Daun johar mengandung senyawa metabolit sekunder berupa alkaloid, flavonoid, saponin, dan tanin. Senyawa metabolit tersebut mempunyai aktivitas antibakteri terhadap Staphylococcus aureus. Senyawa-senyawa tersebut diambil dengan cara maserasi. Maserasi menggunakan pelarut etanol 96% selama 5 hari. Esktrak yang didapat kemudian dibuat menjadi sediaan krim. Penelitian ini dilakukan untuk mengetahui pengaruh perbedaan konsentrasi emulgator terhadap sifat fisik sediaan dan nilai daya hambat pertumbuhan bakteri setelah dibuat menjadi krim. Konsentrasi ekstrak daun johar disetiap formula adalah 8%. Berdasarkan penelitian yang telah dilakukan sebelumnya, ekstrak etanol daun johar dengan konsentrasi 8% dapat menghambat pertumbuhan bakteri Staphylococcus aureus sebesar 14,9 mm. Krim yang dibuat menggunakan emulgator trietanolamin dan setil alkohol. Konsentrasi trietanolamin pada Formula I (2,5%), Formula II (3,0%), Formula III (4,0%). Konsentrasi setil alkohol pada Formula I (2,0%), Formula II (2,5%), Formula III (3,0%). Evaluasi fisik yang dilakukan yaitu organoleptis, homogenitas, viskositas, pH, daya sebar dan daya lekat, serta dilakukan uji aktivitas antibakteri. Hasil data diolah secara statistik menggunakan One Way Anova. Hasil penelitian menunjukkan bahwa Formula III memiliki stabilitas yang paling baik. Hal ini dikarenakan kombinasi 2 emulgator yang mempunyai sifat saling mendukung, yaitu mampu meningkatkan konsistensi sediaan dan memiliki bentuk yang stabil. Formula I memberikan hasil daya hambat yang paling tinggi yaitu 16,8 mm. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak daun johar dapat dibuat sediaan krim dan adanya perbedaan konsentrasi emulgator dapat mempengaruhi stabilitas dan aktivitas antibakteri sediaan krim.
PELATIHAN SENAM HIPERTENSI UNTUK MENGONTROL TEKANAN DARAH PADA PENDERITA HIPERTENSI DI DUSUN TANEN, KEMUNING, NGARGOYOSO, KARANGANYAR Indarto, Indarto; Yulianto, Dwi Joko; Wibowo, Joko Tri; Puspitasary, Kiki
EJOIN : Jurnal Pengabdian Masyarakat Vol. 2 No. 6 (2024): EJOIN : Jurnal Pengabdian Masyarakat, Juni 2024
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/ejoin.v2i6.2892

Abstract

Hypertension is a health problem that is quite dangerous throughout the world because hypertension is the main risk factor that leads to cardiovascular diseases such as heart attack, heart failure, stroke, and kidney disease. In 2016, ischemic heart disease and stroke became the two main causes of death in the world. Based on the 2018 Riskendes Central Java Province Report, data on patients suffering from hypertension in Central Java Province was 63,191, and hypertension sufferers in Karanganyar Regency were 1,651. It is important to carry out health education to control the blood pressure of hypertension sufferers through counseling activities and hypertension exercises. The methods used in this activity are lectures or delivery of material, discussions and questions and answers, checking participants' blood pressure, and hypertension exercises. 47 participants attended. After doing regular hypertension exercises for 2 weeks (twice a week for 30 minutes), the results were obtained in the form of optimal blood pressure increasing, normal high blood pressure decreasing, mild hypertension remaining, moderate hypertension decreasing, severe hypertension remaining, hypertension very severe decline, even non-existent or zero. So it can be concluded that hypertension exercise can be an effort to reduce the blood pressure of hypertension sufferers.
Analisa DRPs Kategori PCNE Pada Pasien Gagal Ginjal Akut Dengan Infeksi Tanpa Hemodialisis Di Rawat Inap RSUD Dr. Moewardi Surakarta Indarto, Indarto; Novitasari, Meliana; Yulianto, Dwi Joko; Agustina, Dwi Tri; Sakka, La
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 8 (2025): SENTRI : Jurnal Riset Ilmiah, Agustus 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i8.4340

Abstract

Acute kidney injury (AKI) is a clinical condition caused by metabolic or pathological damage to the kidneys, characterized by a rapid and significant decline in kidney function along with elevated azotemia levels. This study aimed to analyze the occurrence of AKI due to the impact of drug therapy based on Drug Related Problems (DRPs) as categorized by the Pharmaceutical Care Network Europe (PCNE) in inpatients at Dr. Moewardi General Hospital in 2022. It also aimed to determine the effect of drug therapy on reducing leukocyte and urinary bacteria counts, as well as urea and creatinine levels in patients with infections not undergoing hemodialysis. This was a descriptive, non-experimental study using retrospective qualitative and quantitative methods. Quantitative data were analyzed using linear regression and paired sample t-test, while qualitative data were analyzed using the PCNE DRP classification. The study involved data from 10 patients diagnosed with AKI and infection without hemodialysis, with 18 DRP events identified. The analysis of drug therapy using the PCNE DRP framework showed an influence on kidney function, as several patients who were not initially diagnosed with AKI had elevated urea and creatinine levels upon examination, leading to an AKI diagnosis. However, the therapy given to these 10 patients was not optimal in addressing AKI. The analysis concluded that the drug therapy, although appropriate in its administration, did not significantly impact the reduction of leukocytes, urinary bacteria, or urea and creatinine levels, indicating that the therapeutic outcomes did not meet the expected results.
PEMBERDAYAAN IBU-IBU PKK DALAM UPAYA DETEKSI DINI PENYAKIT DEGENERATIF DI KELURAHAN BALUWARTI, SURAKARTA puspitasary, kiki; Ningrum, Andriani Noerlita; Novitasari, Meliana; Yulianto, Dwi Joko; Indarto, Indarto
EJOIN : Jurnal Pengabdian Masyarakat Vol. 1 No. 12 (2023): EJOIN : Jurnal Pengabdian Masyarakat, Desember 2023
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/ejoin.v1i12.1925

Abstract

Degenerative disease is a condition that occurs due to a decrease in the function of a tissue or organ due to the aging process. It is not uncommon for elderly people to realize this disease only when the disease is already in a serious condition with complications, resulting in an increase in morbidity and mortality rates, as well as a decrease in the elderly's quality of life and a decrease in the elderly's ability to carry out daily activities. One of the early detections carried out is routine checks for three body conditions that can cause various degenerative diseases, namely, checking blood sugar levels, checking uric acid levels, checking cholesterol, and checking blood pressure. Early detection can be done by empowering cadres of PKK women in the environment around where the elderly live. The Baluwarti sub-district area is one of the areas in Surakarta that has elderly people with degenerative diseases. Because of this history, there is a need for control efforts from the government and private sector. One of the efforts is to empower PKK women cadres to carry out early detection of degenerative diseases. The method used in this activity is an educational approach and health examination. The results of the health examination obtained in this activity were elderly people with high blood sugar levels, namely 48.1%; uric acid levels above normal, namely 61.5%; cholesterol levels above normal, namely 53.8%; and high blood pressure, namely 55.8%. This shows that the majority of elderly people in the Baluwarti Village area suffer from degenerative diseases.
Co-Authors Agustina, Dwi Tri Indarto Indarto Joko Tri Wibowo, Joko Tri Murti, Rita Widiyasari Ningrum, Andriani Noerlita Novitasari, Meliana Puspitasary, Kiki Sakka, La