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All Journal Buletin Farmatera Medika Kartika : Jurnal Kedokteran dan Kesehatan JURNAL ILMIAH SIMANTEK Jurnal Pandu Husada
Mourisa, Cut
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Religion Agriculture, Biological Sciences & Forestry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Veterinary

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UJI DAYA HAMBAT EKSTRAK LIDAH BUAYA (Aloe vera l.) TERHADAP PERTUMBUHAN Staphylococcus aureus AMIN LUBIS, M. RIZQI; MOURISA, CUT
JURNAL ILMIAH SIMANTEK Vol 7 No 4 (2023): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

The use of antibacterial is a solution to treat various infectious diseases. However, the mismatch of the dose given can lead to bacterial resistance to these antibacterial substances. So, it is necessary to renew or develop natural medicines to kill bacteria and prevent resistance. One type of plant that can be used as a natural antibacterial is aloe vera (Aloe vera L.) because it contains several active substances including saponins, flavonoids, tannins and polyphenols which are thought to have antibacterial activity. This study used an experimental method with a laboratory observation approach. the results showed that aloe vera extract (Aloe vera L.) in all concentration groups (20%, 40%, 60%, 80%, and 100%) had a significant difference. with a probability value (p) <0.05, which means that aloe vera extract is effective in inhibiting the growth of Staphylococcus aureus bacteria. The conclusion here is Aloe vera extract ( Aloe Vera L) is effective in inhibiting the growth of Staphylococcus aureus
Uji Efektivitas Infus Biji Kopi Sidikalang (Coffea canephora var. robusta) Dan Kopi Gayo (Coffea arabica L.) Dalam Menurunkan Kadar Asam Urat Darah PadaTikus Wistar (Rattus norvegicus L.) Yulsyafrida, Astriani; Mourisa, Cut
JURNAL PANDU HUSADA Vol 4, No 4 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v4i4.17924

Abstract

Abstrak : Kopi merupakan salah satu minuman alternatif yang sangat digemari masyarakat Indonesia. Terdapat dua jenis kopi di Indonesia, yaitu kopi robusta (Coffea canephoravar. robusta) dan kopi arabika (Coffea arabica L.). Daerah penghasil kopi arabika di Indonesia yang memiliki kualitas terbaik dunia terdapat di Provinsi Aceh yang ditanam di dataran tinggi Gayo. Kopi Sidikalang merupakan kopi Sumatera jenis robusta yang berasal dari Sumatera Utara. Kandungan  polifenol yang terdapat dalam kopi berfungsi sebagai antioksidan yang dapat melawan radikal bebas dan menghambat aktivitas enzim xanthine oxidase yang memecah senyawa purin (hipoxanthine dan xanthine) menjadi asam urat sehingga dapat menurunkan kadar asam urat. Penelitian ini bertujuan untuk mengetahui efektivitas infus biji kopi Sidikalang maupun biji kopi Gayo dalam menurunkan kadar asam urat darah pada tikus Wistar (Rattus norvegicus L.). Metode pada penelitian ini adalah eksperimental dengan rancangan penelitian “pre test - post test with control group design”. Menggunakan infus biji kopi Sidikalang dan kopi Gayo. Sampel yang digunakan adalah tikus Wistar (Rattus norvegicus L.) yang terbagi atas 6 kelompok. Analisis data menggunakan repeated ANOVA post hoc bonferroni. Hasil penelitian menunjukkannilai rata-rata kadar asam urat darah pada kelompok kontrol negatif (pre-test=5,08 mg/dL, post-test=4,88 mg/dL), kontrol positif (pre-test=13,08 mg/dL, posttest=6,78 mg/dL), infus biji kopi Sidikalang dengan dosis 0,25 mg/g BB (pre-test=9,28 mg/dL, post-test=6,84 mg/dL), infus biji kopi Sidikalang dengan dosis 0,5 mg/g BB (pre-test=11,62 mg/dL, post-test=7,24 mg/dL), infus biji kopi Gayo dengan dosis 0,25 mg/g BB (pre-test=9,42 mg/dL, post-test=8,48 mg/dL), dan infus biji kopi Gayo dengan dosis 0,5 mg/g BB (pre-test=9,76 mg/dL, post-test=7,66 mg/dL). Terdapat perbedaan kadar asam urat darah yang signifikan sebelum dan sesudah pemberian infus biji kopi Sidikalang dan Gayo pada semua kelompok perlakuan dengan nilai p=0,000 (p0,05). Kesimpulan pada penelitian ini adalah infus biji kopi Sidikalang maupun biji kopi Gayo efektif dalam menurunkan kadar asam urat darah pada tikus Wistar.  
Effect Of Low Doses of Acetylsalicylic Acid (ASA) On the Histopathological Features of Fibroblasts in The Amniotic Membrane Mourisa, Cut; Suryani, Des
Buletin Farmatera Vol 9, No 3 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i3.19907

Abstract

Abstract: Acetylsalicylic acid (ASA) is a drug with several indications such as analgesic, antipyretic, and antithrombotic/antiplatelet. ASA is efficacious as antithrombotic at low doses and used for thrombosis therapy in stroke, antiphospholipid syndrome (APS), pre-eclampsia and eclampsia. However, the administration of ASA made pharmacokinetic interactions that cause a vitamin C deficiency condition. This study aims to determine the effect of low doses of Acetylsalicylic acid (ASA) on the histopathological appearance of fibroblasts on fetal membranes. This study used a cross-sectional design using 54 paraffin membrane blocks as samples processed into histopathological preparations. The case group received low-dose ASA and the control group did not receive low-dose ASA. Histopathological preparations were observed using a microscope to see images / count the number of fibroblast cells. The results showed that there were significant differences between the number of fibroblasts in the case group and the control group with p = 0.001 or p 0.05
Inhibition Test of Aloe Vera Extract (Aloe vera l.) Against the growth of Staphylococcus aureus Amin Lubis, Muhammad Rizqi; Mourisa, Cut
Buletin Farmatera Vol 11, No 1 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v11i1.26486

Abstract

Abstract: The use of antibacterial is a solution to treat various infectious diseases. However, the mismatch of the dose given can lead to bacterial resistance to these antibacterial substances. So, it is necessary to renew or develop natural medicines to kill bacteria and prevent resistance. One type of plant that can be used as a natural antibacterial is aloe vera (Aloe vera L.) because it contains several active substances including saponins, flavonoids, tannins and polyphenols which are thought to have antibacterial activity. This study used an experimental method with a laboratory observation approach. The technique used to measure the extra inhibition of aloe vera (Aloe vera L.) is the well diffusion method. The results showed that aloe vera extract (Aloe vera L.) in all concentration groups (20%, 40%, 60%, 80%, and 100%) had a significant difference. with a probability value (p) 0.05, which means that aloe vera extract is effective in inhibiting the growth of Staphylococcus aureus bacteria. Aloe vera extract ( Aloe Vera L) is effective in inhibiting the growth of Staphylococcus aureus.
ANALYSIS OF KIDNEY FUNCTION PARAMETERS ON THE RENOPROTECTIVE EFFECTS OF ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH CHRONIC KIDNEY FAILURE Mourisa, Cut; Sukatendel, Firya Nadine Chalishny
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

The renoprotective effect in chronic kidney disease (CKD) patients can be induced by antihypertensive therapy, which provides a vasodilatory effect on the blood vessels leading to the kidneys. This resulting renoprotective function is considered to slow the decrease in kidney function in CKD patients. The purpose of this study was to examine the effectiveness of antihypertensive therapy as renoprotective agents through the analysis of kidney function parameters in CKD patients. A descriptive design with a cross-sectional method was used, and the study sample used data from patient medical records, specifically focusing on kidney function parameters of CKD patients during the January-June 2023 treatment period at RSUD Sultan Abdul Aziz Syah Peureulak. Of the 134 respondents, there were two groups of patients receiving antihypertensive therapy: ACE-Inhibitors (ACEIs) and (angiotensin receptor blockers) ARBs. After conducting the Wilcoxon test, there were significant changes in kidney function parameters (Urea, creatinine, and eGFR) between before and after antihypertensive therapy, with a p value <0.05. In the ACEI group, the mean urea level was 72.4 ± 48.3 mg/dL, creatinine 4.8 ± 4.3 mg/dL, and eGFR 30.6 ± 30.8 mL/min. In the ARB group, mean urea was were 85.2 ± 48.7 mg/dL, creatinine 6.1 ± 4.2 mg/dL, and eGFR 21.6 ± 26.7 mL/min. These findings indicate that ACEI and ARB antihypertensive therapies are effective as renoprotective agents in CKD patients. Keywords: ACE-Inhibitor, antihypertensive, ARB, reno-protective effect DOI : 10.35990/mk.v8n4.p412-422
Co-Authors AMIN LUBIS, M. RIZQI Amin Lubis, Muhammad Rizqi Des Suryani Sukatendel, Firya Nadine Chalishny Yulsyafrida, Astriani