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All Journal Jurnal Kesehatan Andalas Bali Dermatology and Venereology Journal
Veronica, Elvina
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Systematic review of melasma treatments: advantages and disadvantages Suryantari, Sang Ayu Arta; Sweta, Ni Putu Tamara Bidari; Veronica, Elvina; Hartawan, I Gusti Ngurah Bagus Rai Mulya; Karna, Ni Luh Putu Ratih Vibriyanti
Bali Dermatology and Venereology Journal Vol 3, No 2 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i2.41

Abstract

Background: Melasma is an acquired chronic hyperpigmentation mostly affecting women. The pathogenesis of melasma is uncertain but it predominant related to ultraviolet (UV) exposure. Due to chronic and relapsing nature, melasma is challenging to treat. The current available treatment often has undesirable side effects and suboptimal results. The principal of treatment includes protect from UV radiation, inhibit melanin synthesize and increase pathway to remove melanin. Objectives: To define available treatments for melasma and determine advantages and disadvantages including topical, oral and procedural. Method: Medline, Cochrane library and PubMed database were searched for articles from January 2011 to June 2020. Only RCTs, comparative, prospective, retrospective and systematic reviews focusing on melasma treatments were extracted, analyzed and discussed. Results: We found 197 studies that met the inclusion and exclusion criteria with 2314 participants included in this review. The treatments included topical, oral and procedural. In several studies, hydroquinone alone or combination remains the most effective treatment for melasma. Oral and topical tranexamic acid have been found to be a useful adjuvant treatment in refractory melasma with minimal adverse effects. Procedural treatment such as chemical peels, laser and light-based therapies, and microneedling have a mixed and unpredictable result. Overall, the side effects tend to be mild and affect few of the subject.Conclusions: The current state of the evidence suggests that some treatments with multiple modalities have their respective advantages and disadvantages. The choice of treatment modality must be adjusted according to the type of melasma such as its severity, extent and location. A better understanding of melasma through the further research may improve the therapy options with the least adverse effects.
Potensi Ekstrak Kunyit (Curcuma longa) Terhadap Kadar Ischemia Modified Albumin (IMA) pada Tikus Model Penyakit Jantung Koroner Dharmaputra, Gde Arisetyawan; Veronica, Elvina; Driansha, Cindy Liora; Satyarsa, Agung Bagus Sista; Dewi, Ni Wayan Sucindra
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1392

Abstract

Penyakit Jantung Koroner (PJK) adalah penyakit kardiovaskuler akibat penyempitan pembuluh darah koroner yang menyebabkan iskemia miokard, sehingga mengakibatkan apoptosis sel. Kunyit mengandung senyawa yang berperan sebagai anti inflamasi, seperti kurkumin.  Tujuan: Menentukan pengaruh kandungan kurkumin pada kunyit (Curcuma longa) terhadap kadar Ischemia Modified Albumin (IMA). Metode: Desain penelitian ini adalah rancangan post-test only control group dengan menggunakan tikus wistar jantan sebanyak 30 ekor yang terbagi ke dalam 5 kelompok yaitu, kelompok 1 kontrol negatif, kelompok 2 kontrol positif, kelompok perlakuan 1, 2, dan 3. Kelompok perlakuan masing-masing mendapatkan ekstrak kunyit dengan variasi dosis 50, 100, dan 200 mg/kgBB. Pemeriksaan kadar IMA dalam serum darah menggunakan teknik ELISA. Data dianalisis dengan uji One-Way Anova. Hasil: Kadar IMA pada masing masing kelompok adalah kelompok 1 kontrol negative = 300,471 ng/mL, kelompok 2 kontrol positif = 333,357 ng/mL, kelompok perlakukan 1 dosis 50mg/kg = 232,317 ng/mL, kelompok perlakukan 2 dosis 100 mg/kgBB = 173,385 ng/mL, dan kelompok perlakuan 3 dosis 200 mg/kgBB =  217,358 ng/mL. Hasil analisis statistik menunjukkan tidak terdapat perbedaan yang bermakna kadar IMA antara semua kelompok penelitian, yakni kelompok kontrol positif, kontrol negatif, maupun kelompok perlakuan (p>0,05). Berdasarkan Independent  t-test menunjukkan terdapat perbedaan yang bermakna kadar IMA antara kelompok perlakuan ekstrak kunyit 100 mg/kgBB, 200 mg/kgBB dengan kelompok kontrol positif. Simpulan: Ekstrak kunyit berpengaruh terhadap kadar IMA.Kata kunci: IMA, kunyit, kurkumin
Co-Authors Agung Bagus S. Satyarsa Dewi, Ni Wayan Sucindra Dharmaputra, Gde Arisetyawan Driansha, Cindy Liora Hartawan, I Gusti Ngurah Bagus Rai Mulya Ni Luh Putu Ratih Vibriyanti Karna Sweta, Ni Putu Tamara Bidari