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All Journal Current Biomedicine Jurnal Kesehatan Kartika
Tantan, Acep
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Sensitivity and specificity of the lipoarabinomannan test compared to GeneXpert in urine samples for tuberculosis diagnosis Irawan, Danni; Rismiarti, Zuri; Tantan, Acep; Merdekawati, Fusvita
Current Biomedicine Vol. 3 No. 1 (2025): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.3.1.7

Abstract

Background Mycobacterium tuberculosis (MTB) is the causative agent of tuberculosis (TB), primarily affecting lung tissue but also capable of infecting pleura, lymph nodes, bones, and other extrapulmonary sites. Lipoarabinomannan (LAM) is a critical lipopolysaccharide in the outer wall of mycobacterial cells and can be detected in the urine of TB patients as an antigen. Objective This study aimed to assess the sensitivity and specificity of the LAM test compared to GeneXpert in urine samples from suspected TB patients. Methods A quasi-experimental design was employed, where urine samples were collected from patients diagnosed with TB at Sidawangi Lung Hospital, West Java Province. The LAM test was performed on 40 samples by applying 60 µL of urine onto LAM test strips, while MTB presence in urine was examined using GeneXpert. Results LAM test results showed 32.5% positivity, while 67.5% were negative. GeneXpert results indicated 20% positivity and 80% negativity. The LAM test demonstrated a sensitivity of 100% and specificity of 79.4% compared to GeneXpert, with an area under the curve (AUC) value of 0.897. Conclusion The LAM test showed high sensitivity and moderate specificity compared to GeneXpert in urine samples of suspected TB patients.
PENGARUH SUHU DAN WAKTU PENYIMPANAN SERUM TERHADAP KADAR C-REACTIVE PROTEIN PADA PASIEN TUBERKULOSIS Desta, Sally; Khairinisa, Gina; Tantan, Acep; Gita Naully, Patricia
JURNAL KESEHATAN KARTIKA Vol. 19 No. 3 (2024): Jurnal Kesehatan Kartika
Publisher : Faculty of Health Science and Technology, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkkes.v19i3.319

Abstract

Background : Tuberculosis is a chronic infectious disease that can be spread through air exposed to Mycobacterium tuberculosis bacteria. This disease can generally attack the lung organ which will then cause inflammation. Inflammation is a mechanism process carried out by the body in defending itself against foreign objects that enter the body. C-Reactive Protein is an acute protein produced by the liver and can be found in normal serum with a small amount, but will increase when given a stimulus such as infection, burns, and postoperative. Objective : to test CRP levels and determine the effect of temperature and storage time on CRP levels in the serum of Tuberculosis patients. Method : using Pre-experimental design one group pretest postest design, then data analysis using dependent T test and Wilcoxon test. This study conducted qualitative and semi-quantitative CRP examination on serum stored at room temperature (20-25℃) and refrigerator temperature (2-8℃) for 24 and 48 hours. Results : The results obtained at refrigerator temperature showed that the p-value> 0.05 had no significant relationship with serum stored in 24 and 48 hours. At room temperature, the p-value <0.05 is known to have a significant relationship. Conclusion : In this study, there was no effect on sample storage temperature on CRP levels examined at 0, 24, and 48 hours in the serum of tuberculosis patients. There was an effect on the length of sample storage on CRP levels examined at 0, 24, and 48 hours in the serum of tuberculosis patients.
Co-Authors Desta, Sally Gina Khairinisa Gita Naully, Patricia Irawan, Danni Merdekawati, Fusvita Zuri Rismiarti