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All Journal Indonesian Journal of Cardiology Medica Hospitalia Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Asrial, An Aldia
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Computer Science & IT Dentistry Engineering Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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inggris Asrial, An Aldia; Pudjiastuti, Anggit; Herry, Yan; Bahrudin, Udin
Jurnal Kardiologi Indonesia Vol 43 No 2 (2022): Indonesian Journal of Cardiology: April - June 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1324

Abstract

Background Zwolle, TIMI, and GRACE risk scores have been proven to predict mayor adverse cardiovascular events (MACE) in STEMI patients undergoing primary percutaneous coronary intervention (PCI). However, they were developed over a long time ago which many advances have been made in the cardiovascular field today. The scores were also developed in the non-Asian majority population and their accuracy for Indonesian population remains unknown. We aimed to validate and compare these scores for Indonesian population. Methods An analytical observational study was conducted on 193 patients undergoing primary PCI. The Zwolle, GRACE, and TIMI risk scores were calculated for each patient. Then, the risk score validation was carried out with the calibration test using Hosmer Lemeshow test and discrimination test using the AUC ROC. Furthermore, the comparisons between the risk scores were carried out using the DeLong test. Results The three scores have good results in the Hosmer Lemeshow calibration test (p > 0.05). The discrimination test also indicated good results with AUC ROC Zwolle, TIMI and GRACE risk scores respectively 0.776; 0.782; 0.831 (p<0.05). There was no significant difference in the prediction accuracy of the three risk scores in the DeLong test. Conclusions The Zwolle, TIMI, and GRACE risk scores had good validity for predicting major adverse cardiovascular events in STEMI patients undergoing primary PCI. There was no significant difference in the prediction accuracy of the three risk scores. Keywords: Risk score, major adverse cardiovascular events, primary percutaneous coronary interventions
Pengembangan Skor Risiko KARIADI Sebagai Metode Stratifikasi Risiko Kejadian Kardiovaskular Mayor Pasca Intervensi Koroner Perkutan Primer Asrial, An Aldia; Herry, Yan; Udin, Bahrudin; Anggriyani, Novi; Suhartono, Suhartono
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 1 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (352.157 KB) | DOI: 10.36408/mhjcm.v9i1.640

Abstract

Background Reduction of major cardiovascular events (MACE) in ST elevation acute coronary syndrome (STE-ACS) patients has been achieved by primary percutaneous coronary intervention (PCI) strategy and intensive care management. However, the intensive care unit bed availability and cost remain a problem for those patients, and thus risk stratification using an objective risk score instrument is required. Aim To develop a risk score of in-hospital MACE for patients with STE-ACS underwent primary PCI. Methods A cohort study of 208 patients with STE-ACS undergoing primary PCI at the Dr. Kariadi General Hospital Semarang. Predictor analysis was carried out using bivariate Chi-Square test and multivariate logistic regression. The obtained independent predictors were then used as risk score variables. The quality of the risk score was tested by the Hosmer and Lemeshow calibration test and AUC ROC analysis for discrimination test. Results Seven out of 13 independent predictors, i.e. Killip class (OR 20,04, p=0,0001), age (OR 3,02, p=0,04), renal insufficiency (OR 9,48, p=0,007), infark related artery final TIMI flow (OR 11,57, p=0,001), admission systolic blood pressure (OR 3,04, p=0,025), duration of total ischaemic time (OR 3,14,p=0,032) and increase of blood glucose levels (OR 3,04, p=0,029) were fulfilled the criteria for risk scores of in-hospital MACE. The risk scores had a good quality with the Hosmer and Lemeshow calibration test> 0,05 and ROC AUC 0,886 (95% CI, 0,827-0,944, p <0,005). Conclusions A risk scoring modele consisting of 7 independent predictor variables i.e. Killip class, age, renal insufficiency, infark related artery final TIMI flow, admission systolic blood pressure, duration of total ischaemic time, and increase of blood glucose levels (KARIADI) has a good calibration and discrimination in predicting the risk of in-hospital MACE in patients with STE-ACS underwent primary PCI. Keywords Predictors of in-hospital MACE, primary PCI, ST-segment elevation acute coronary syndromes, risk score.
Correlation of NT-pro BNP Levels with Right Ventricular Parameters in Heart Failure due to Mitral Stenosis Asrial, An Aldia; Pudjiasti, Anggit
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5488

Abstract

Purpose: Mitral stenosis (MS) is a common valvular heart disease that often causes heart failure (HF). The right ventricle (RV) is frequently involved in MS, which contributes to clinical outcomes in patients. NT-pro BNP (N-terminal pro-B-type natriuretic peptide) is a widely used biomarker in the diagnosis and prognosis of heart failure. However, its relationship with RV parameters in patients with HF due to MS remains insufficiently explored. This study aimed to explore the correlation between NT-pro BNP levels and right ventricular parameters in patients with mitral stenosis. Methodology: A total of 40 outpatient subjects with severe MS were included in this study. NT-pro BNP examination was performed using the ELISA method. RV parameter assessment was performed using echocardiography by assessing TAPSE (function) and RV basal diameter (dimension). Results: RV function parameters (TAPSE) and NT-pro BNP showed a significant weak correlation (r=0.324; p=0.041). RV dimension parameters and NT-pro BNP did not show a significant relationship. Patients with RV dysfunction had greater increases in NT-pro BNP levels compared to patients with normal RV function (6441.25±773.18 vs 7671.87±788.72 pg/mL; p=0.172). Applications/Originality/Value: Provides valuable insights into the pathophysiology of right heart involvement in MS and provides clinicians with potential biomarkers for early identification of RV dysfunction in MS patient population.
Co-Authors AA Sudharmawan, AA Herry, Yan NOVI ANGGRIYANI, NOVI Pudjiasti, Anggit Pudjiastuti, Anggit Udin Bahrudin, Udin Udin, Bahrudin