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All Journal Indonesian Journal of Pharmacology and Therapy
Yuniyanti, Mia Munawaroh
Unknown Affiliation
Immunology & microbiology Medicine & Pharmacology

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The resistance status of Aedes aegypti larvae to Temephos in Depok, Sleman, Yogyakarta Yuniyanti, Mia Munawaroh; Umniyati, Sitti Rahmah; Ernaningsih
Indonesian Journal of Pharmacology and Therapy Vol 2 No 1 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1329

Abstract

There are still many cases of dengue hemorrhagic fever and tend to increaseover time. One strategy to reduce the increase in cases of dengue infection isto eradicate Aedes aegypti as a vector using insecticides. The use of insecticidesfor a long time can cause resistance. The purpose of this study was to determinethe resistance status of Aedes aegypti larvae against temephos in Depok, Sleman.This quasi experimental test was carried out on 3rd instar larvae of aedesaegypti from RW 9 and 10 Minomartani, Depok, Sleman. The treatment groupwas exposed 0.02 ppm temephos for 24 hours. The analysis was presented in theform of percentage of larval mortality and resistance categories based on WHOguidelines. The mortality percentage of Aedes aegypti larvae in RW 9 was 100%,while the mortality from RW 10 was 97%. Aedes aegypti larvae in Depok district,Sleman are still susceptible to temephos at a dose of 0.02 ppm.
Coral plant (Jatropha multifida L) leaf extracts inhibit dengue virus-2 (DENV-2) growth through NS5 Yuniyanti, Mia Munawaroh; Sri Hartati Wahyuningsih, Mae
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.11410

Abstract

The incidence of dengue fever (DF) increases drastically from year to year, especially in tropical countries like Indonesia. In contrast, antiviral against dengue virus (DENV) is not available in clinics, yet. Jatropha multifica L, locally named tanaman yodium/coral plant, is a medicinal plant that is traditionally used to treat dengue hemorrhagic fever (DHF). However, its scientific evidence is limited. This study aimed to investigate the antiviral activity of J. multifida L leaf extracts against DENV-2 and evaluate the effect on NS5 RNA expression. The leaf extracts were prepared by multilevel extraction using chloroform and methanol. The study was conducted in vitro using DEN-2 and Vero cells. The antiviral activity was assessed by using qRT-PCR to assess the number of virus copies and then used to calculate the inhibitory concentration of 50% (IC50). The effect of the most active extract on NS5 DENV-2 RNA expression was then evaluated by using qRT-PCR. Among 4 extracts tested, the methanolic insoluble chloroformic extract (MIS) is the most active with an IC50 value of 124.3 μg/mL. Furthermore, the MIS (0.02) strongly inhibited NS5 DENV-2 RNA expression compared to control (1.0). In conclusion, the MIS of J. multifida is active against DENV-2 through inhibition of NS5 RNA expression.
Co-Authors Ernaningsih Sitti Rahmah Umniyati Sri Hartati Wahyuningsih, Mae