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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Patologi Indonesia
Heni Maulani
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Hubungan antara Ekspresi Vascular Endothelial Growth Factor (VEGF) dengan Karakteristik Klinikopatologik Karsinoma Payudara Duktal Invasif Huratio Nelson; Heni Maulani; Aida Farida; Irsan Saleh
Majalah Patologi Indonesia Vol 23 No 1 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Breast cancer is the most common malignancy and related death of female worldwide. The angiogenesis has an important role in the invasive ductal mammary carcinoma carcinogenesis, and vascular endothelial growth factor (VEGF)is a primary angiogenic factor. The aim of this study is to determine the relationship between the VEGF expression and clinicopatologic characteristics of the invasive ductal mammary carcinoma. Methods It was a cross-sectional study. Fifty-five parafin block samples of mastectomy tissue diagnosed as invasive mammary ductal carcinoma were obtained from the archieves of the Anatomical Pathology Department of RSMH, was stained by immunohistochemical method with anti-VEGF antibody. The result was analyzed in relation to age, tumor size, lymph node status, and histological grade. Results The positivity of VEGF expression was more common in the ≤49 years age of group, in the tumor of ≥9,6 cm size group, in the positive lymph node status, and in the high histological grade. There was a significant correlation between the VEGF expression and the category of lymph node status (p=0.047), as well as histological grade (p=0.020). There was unsignificant correlation between VEGF expression and the age category (p=0.781), as well as tumor size category (p=0.700). Conclusion There was correlation between VEGF expression and lymph node status and histological grade in invasive ductal mammary carcinoma. Key words: clinicopathologic characteristics, invasive ductal mammary carcinoma, VEGF.
Hubungan antara Ekspresi Ki-67 dengan Stadium Klinis dan Derajat Histopatologis Karsinoma Sel Skuamosa Serviks Nita Hertati; Heni Maulani; Zulkarnain Musa; Zen Hafy
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Background Cervical cancer is the third most common type and the fourth most deadly cancerian women which remains a significant health problem worldwide especially in developing coumtry. Ki-67 is a prototype protein in nuclear which influence cell proliferation rate, hence it can be used as one of parameter to evaluate progressivity of tumor cells in carcinoma cases as the cervical squamous cell carcinoma (SCC). This study aims to determine the relationship between clinical staging of cervical SCC and histopatological grading of the cervical SCC with the expression of Ki-67. Methods This was an observational study with a cross sectional design. Sixty cervical squamousa cell carcinoma archive histopathological slide samples (45 biopsy specimens and 15 radical hysterectomy tissues) were collected for this study from the Anatomical Pathology Department of RSUP dr. Mohammad Hoesin Palembang (January 2008 to July 2013). The samples were stained with Ki-67 antibody and analyzed with respect to patient’s clinical stage and histopatological grade. Results The positivity of Ki-67 expressions were more common in the age of ≤ 50 year-old group, in the non-keratinizing type, in the late clinical staging (stage IIIB) and in the moderatelly differentiated histopathological grade. High scores of the Ki-67 expressions (Ki-67>20%) was predominantly found in the late clinical stage and moderatelly differentiated histopathological grade cases. Statistically, there was a significant relationship (p=0.034) with a strong correlation (r=0.714) between the Ki-67 ecpression and the clinical stage of cervical SCC, but not histopathological grade. Conclusion The higher clinical staging of cervical SCC, the higher expression of Ki-67. Key words: cervical squamous cell carcinoma, clinical staging, histophatological grade, Ki-67.
Hubungan Kepadatan Tumor Associated Macrophages CD-68 dan Karakteristik Klinikopatologi pada Karsinoma Payudara Invasif Miko Kresna Handayani; Heni Maulani; Nursanti Apriyani
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.25 KB) | DOI: 10.55816/mpi.v29i2.417

Abstract

BackgroundBreast carcinoma is the most common malignancy among women worldwide. Many factors can influence prognosis of the disease.Tumor microenvironment (TME) is enriched in highly active immune cells. Herein, tumor associated macrophages (TAM) are themost prevalent immune cells. TAM can enhance tumor progression by promoting angiogenesis, invasion and metastasis. Somestudies demonstrate that high density of macrophages infiltration associated with poor prognosis. The aim of the study is todetermine the association between TAM density and clinicopathological characteristics of breast invasive carcinoma.MethodsDescriptive study with case series design on January 1, 2015-October 31, 2017 was performed at Department of AnatomicalPathology Faculty of Medicine University of Sriwijaya/dr. Moh. Hoesin General Hospital Palembang on 48 samples invasivecarcinoma mammae subtype unspecific, and have already staining with immunohistochemistry staining ER, PR, HER-2 and Ki-67,surrogate markers. Then immunohistochemistry staining using CD-68 antibody was conduced. The association between TAMdensity and clinicopathological characteristics were analyzed by using Spearman’s Rho test.ResultsThe majority of the patient are older than 40 years of age (77.1%), with positive lymphovascular invasion (79.2%), and at the gradeIII (62.5%). Bivariate analysis between TAM CD-68+density in stromal tumor and subtype luminal A showed negative correlationmoderate significantly (r= -0.398; p=0.005) while between TAM CD-68+density in stromal tumor and subtype triple negative showedpositive correlation moderate significantly (r=0.335; p=0.020).ConclusionTAM CD-68+density in stromal tumor was significantly correlated with luminal A and triple negative subtype.
Hubungan Tingkat Ekspresi Fibroblast Activation Protein (FAP) Terhadap Faktor Klinikopatologi Karsinoma Tiroid Papiler Herlina; Heni Maulani; Nursanti Apriyani
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.817 KB) | DOI: 10.55816/mpi.v30i3.478

Abstract

BackgroundPapillary thyroid carcinoma is the most common subtype among thyroid cancers. The interaction between cancer cells and tumormicroenvironment plays roles in cancer proliferation and invasiveness. One of important components of tumor microenvironmentthat could stimulate tumor proliferation and invasiveness is activated fibroblast, known as carcinoma associated fibroblasts (CAFs).The aim of this research is to analysed FAP expression is associated with clinicopathologic characteristics.MethodsThis retrospective descriptive observational study with serial cases design was conducted in 40 samples of the paraffin blocks oftissues registered in Department of Anantomical Pathology Faculty of Medicine University of Sriwijaya/Dr. Moh. Hoesin PalembangHospital from January 1st, 2017 to October 31st, 2019. All samples were immunostained with FAP antibody. The expressions of FAPwere evaluated in accordance with the results of the previous study. Statistical test was performed by using Chi-square andSpearman-rho statistical test. Statistical analysis was performed by using SPSS version 23.0.ResultsOur data indicated that patients who were ≥45 years old (21 cases; 52.5%), women (31 cases; 77.5%) suffered from this cancer themost. The stromal type found in ten classic, follicular, solid and columnar variance were pauci (25 cases; 62.6%), desmoplastic (8cases;20%), sclerosis (5 cases; 12.5%) and inflammatory (2 cases; 5%). The expression of FAP in tumor stroma has a significantcorrelation with histopathology subtypes (p=0.028) and stromal type (p=0.000).ConclusionFAP was expressed in tumor epithelial cells and fibroblast stromal tumour of papillary thyroid carcinoma. FAP expression in stromaltumor between histopathologic subtype and stromal type showed significant correlation
Korelasi Antara Overekspresi p53 Dengan Derajat Histopatologi Dan Stadium Klinis Karsinoma Ovarium Tati Lahmuddin; Heni Maulani; Zulkarnain Musa; Irsan Saleh
JURNAL KEDOKTERAN DAN KESEHATAN Vol 2, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Karsinoma ovarium adalah keganasan yang berasal dari sel-sel epitelial di ovarium, terbanyak keenam pada wanita di dunia. Di RS Umum Dr. Mohammad Hoesin Palembang, insiden karsinoma ovarium menempati urutan ketiga keganasan terbanyak pada wanita setelah karsinoma payudara dan leher rahim. Gen TP53 mensintesis protein p53 yang bila inaktif dapat mempengaruhi derajat histopatologi dan stadium klinik. Penelitian ini bertujuan mengetahui korelasi antara overekspresi p53 dengan derajat histopatologi dan stadium klinik karsinoma ovarium.  Penelitian dilakukan secara analitik observasional, pendekatan potong lintang di sentra diagnostik laboratorium Patologi Anatomi RS Umum Dr. Mohammad Hoesin Palembang. Sampel berjumlah 32 kasus, diambil dari arsip rekam medik periode 1 Januari 2012 sampai 30 Juni 2015, dipulas dengan antibodi monoklonal p53. Hasil penelitian menemukan frekuensi karsinoma ovarium derajat rendah sebanyak 65,6% dan derajat tinggi sebanyak 34,4%. Tipe histopatologi terbanyak adalah karsinoma serosa derajat tinggi (25%) dan karsinoma musinus (25%). Frekuensi karsinoma ovarium stadium lanjut (53,1%) lebih banyak dari stadium awal (46,9%).  Frekuensi overekspresi p53 pada karsinoma ovarium 43,8%. Tidak ada korelasi bermakna antara overekspresi p53 dengan derajat histopatologi (p=0,1) dan stadium klinis karsinoma ovarium (p=0,6). Terdapat korelasi bermakna antara derajat histopatologi dan stadium klinik (p=0,00, r=0,46)
Sensitivitas dan Spesifisitas Polimerase Chain Reaction pada Diagnosis Her2/Neu Karsinoma Payudara Duktal Invasif Wresnindyatsih Wresnindyatsih; Triwani Triwani; Yuwono Yuwono; Heni Maulani
JURNAL KEDOKTERAN DAN KESEHATAN Vol 2, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Karsinoma payudara duktal invasif adalah keganasan yang berasal dari sel epitel pelapis duktal-lobuler payudara. Gen her2/neu merupakan salah satu gen yang mengalami amplifikasi dan menyebabkan terjadinya  karsinoma payudara. Penemuan terapi target anti her2/neu menurunkan angka kematian dan memperpanjang harapan hidup penderita. Penelitian ini bertujuan memperoleh nilai sensitivitas dan spesifisitas Polymerase Chain Reaction diagnosis status her2/neu pada karsinoma payudara dibandingkan dengan pemeriksaan imunohistokimia. Uji diagnostik telah dilakukan di Laboratorium Patologi Anatomi RSUP dr. M. Hoesin dan Balai Besar Laboratorium Kesehatan Palembang pada bulan Januari sampai November 2013. Sebanyak 39 sampel blok paraffin jaringan karsinoma payudara diambil secara purposif. Dari hasil penelitian terhadap sampel pemeriksaan imunohistokimia didapatkan hasil positif 17,94% (7 dari 39 sampel). Pemeriksaan  dengan metode Polymerase Chain Reaction didapatkan hasil positif 28,20% (11 dari 39 sampel) yang ditandai dengan adanya amplikon DNA spesifik her2/neu >2,0. Berdasarkan hasil tersebut  didapatkan sensitivitas  dan spesifisitas metode Polymerase Chain Reaction 57,14% dan 81,81% dan memiliki nilai prediksi positif dan nilai prediksi negatif 50,00% dan 85,71%. Dapat disimpulkan bahwa pemeriksaan metode Polymerase Chain Reaction memiliki sensitivitas lebih rendah daripada metode IHK namun spesifisitas lebih baik dibandingkan dengan metode IHK. Metode PCR dapat dikembangkan sebagai metode alternatif untuk mendiagnosis status her2/neu.
Co-Authors Fadillah Herlina Huratio Nelson Irsan Saleh Jayawarsa, A.A. Ketut Miko Kresna Handayani Nita Hertati Nursanti Apriyani Tati Lahmuddin Triwani Triwani Wresnindyatsih Wresnindyatsih Yuwono Yuwono Zen Hafy Zulkarnain Musa