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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Patologi Indonesia
Nita Hertati
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Hubungan antara Ekspresi Ki-67 dengan Stadium Klinis dan Derajat Histopatologis Karsinoma Sel Skuamosa Serviks Nita Hertati; Heni Maulani; Zulkarnain Musa; Zen Hafy
Majalah Patologi Indonesia Vol 23 No 3 (2014): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Background Cervical cancer is the third most common type and the fourth most deadly cancerian women which remains a significant health problem worldwide especially in developing coumtry. Ki-67 is a prototype protein in nuclear which influence cell proliferation rate, hence it can be used as one of parameter to evaluate progressivity of tumor cells in carcinoma cases as the cervical squamous cell carcinoma (SCC). This study aims to determine the relationship between clinical staging of cervical SCC and histopatological grading of the cervical SCC with the expression of Ki-67. Methods This was an observational study with a cross sectional design. Sixty cervical squamousa cell carcinoma archive histopathological slide samples (45 biopsy specimens and 15 radical hysterectomy tissues) were collected for this study from the Anatomical Pathology Department of RSUP dr. Mohammad Hoesin Palembang (January 2008 to July 2013). The samples were stained with Ki-67 antibody and analyzed with respect to patient’s clinical stage and histopatological grade. Results The positivity of Ki-67 expressions were more common in the age of ≤ 50 year-old group, in the non-keratinizing type, in the late clinical staging (stage IIIB) and in the moderatelly differentiated histopathological grade. High scores of the Ki-67 expressions (Ki-67>20%) was predominantly found in the late clinical stage and moderatelly differentiated histopathological grade cases. Statistically, there was a significant relationship (p=0.034) with a strong correlation (r=0.714) between the Ki-67 ecpression and the clinical stage of cervical SCC, but not histopathological grade. Conclusion The higher clinical staging of cervical SCC, the higher expression of Ki-67. Key words: cervical squamous cell carcinoma, clinical staging, histophatological grade, Ki-67.
THE IMPACT OF RAD6 EXPRESSION ON CHEMORESISTANT OVARIAN CANCER: A SYSTEMATIC REVIEW Vernadesly, Leo; Nita Hertati; Pariyana
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.477

Abstract

Chemotherapy is one of the modalities for treating ovarian cancer (OC), which is one of the most common reproductive organ cancers in women worldwide. Overexpression of RAD6 has been identified as a significant factor in chemoresistance in ovarian cancer patients. This systematic review aims to evaluate the relationship between RAD6 overexpression and chemoresistance in ovarian cancer. The databases used include PubMed, ProQuest, Science Direct, and Google Scholar, focusing on articles from the last 10 years. Out of 162 articles retrieved, only 4 met the selection criteria and were used in the analysis. The analysis results indicate that RAD6 overexpression is closely associated with increased resistance to chemotherapeutic agents, particularly platinum. The underlying mechanisms include enhanced DNA damage tolerance, increased proliferation, invasion, and the ability of cancer cells to develop stem-like phenotypes. These findings highlight RAD6 as a potential therapeutic target in preventing chemoresistance in OC. Further research is needed to develop specific RAD6 inhibitors that can be used in combination with conventional chemotherapy to improve treatment response and patient prognosis.
Co-Authors Heni Maulani Pariyana Vernadesly, Leo Zen Hafy Zulkarnain Musa