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All Journal Majalah Kedokteran Andalas Jurnal Penyakit Dalam Indonesia
Upadhana, Putu Satyakumara
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Health Professions Medicine & Pharmacology Public Health

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Atherogenic Index of Plasma is Correlated with Prolonged Length of Stay in COVID-19 Patients with Type 2 Diabetes Mellitus in RSUP Sanglah Denpasar Sastrawan, I Gede Gita; Upadhana, Putu Satyakumara; Handayani, Putu Novi; Laela, Tika Rizki Nur; Dewi, Kadek Aprilia Sukma; Wiguna, I Nyoman Bayu Andika; Trisna, Cindy Gracia; Putri, Komang Anjani; Agrasidi, Komang Adya Data; Sudarmika, Putu
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

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Introduction. Atherogenic index of plasma (AIP) is a logarithmic calculation of the ratio of triglycerides to HDL cholesterol as a marker of lipid profile abnormalities. In COVID-19 patients with comorbid type 2 diabetes mellitus (T2DM), higher AIP tend to worsen the patient conditions. This study aims to assess the correlation between AIP and length of stay (LOS) in COVID-19 patients with T2DM.Methods. An analytical observational study with a cross-sectional approach was conducted among COVID-19 patients with comorbid T2DM. Data were collected from online medical records of confirmed COVID-19 patients with comorbid T2DM who were treated at Sanglah Hospital Denpasar during the period August 1-December 31, 2021. Patients who were <18 years old and did not have lipid profile data during>treatment, were excluded from this study.Results. There were 83 data samples that met the study criteria. The median age of the patients was 64 (23- 91) years, the majority were male (59%; n=49), and 30 patients died during treatment (36.1%). The median LOS for all patients was 10 (1-26) days. Patients with prolonged LOS (≥10 days) had higher triglyceride levels (171.8 vs. 120 mg/dL; p<0.001) and AIP values (0.442 vs. 0.286; p=0.02). There was a strong relationship between AIP and LOS values in COVID-19 patients with T2DM (r=0.632; p<0.001). The AIP value can well-discriminated in prolonged LOS conditions (AUC=0.883; 95%CI 0.792-0.974) with the optimal cut-off value of 0.3045 (sensitivity 75.9% and specificity 83.3%).Conclusion. AIP is correlated with prolonged LOS in COVID-19 patients with T2DM. Holistic management of COVID-19 patients with T2DM is urgently needed, including lipid profile control.
Kidney Disease and Its Impact on COVID-19 Patients at Sanglah Hospital Denpasar, Bali, Indonesia in 2021 Upadhana, Putu Satyakumara; Sastrawan, I Gede Gita Sastrawan; Chintya Cahyarini, I Gusti Agung Ayu; Umam, Anbiya Khairul; Putri, Amanda Trisliana Dwi; Adhyatma, I Gede Raka; Somia, I Ketut Agus
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Introduction. Besides having an impact on the respiratory system, COVID-19 also has an impact on other organ such as the kidneys. The systemic inflammatory response thought to be associated with bad prognosis of COVID-19 patients with kidney disease. This study aimed to determine the impact of kidney disease on COVID-19 patients. Methods. This study is an observational analytic study with a cross-sectional approach. The data used is secondary data from the records of confirmed COVID-19 patients who were treated at Sanglah Hospital from 1 May 2021 to 31 August 2021 using total sampling technique.Results. There were 248 patients included in this study. The majority of patients were male (52.4%) with the median overall age of the patients was 59 (range 20–92) years. Most of the patients were severe COVID-19 (65.3%). A total of 77 patients had kidney disease (31.0%) which the most common kidney disease found in patients was acute on chronic kidney disease (n=33; 42.8%). There were significant differences in hemoglobin (p<0.001), blood urea nitrogen (BUN) (p<0,001), serum creatinine (p<0.001), and procalcitonin (p<0.001) in patients classified based on kidney disease. Chi-square analysis showed that COVID-19 patients with kidney disease was correlated with sepsis [PR=2.587 (95%CI 1.750-3.824); p<0.001)], mortality [PR=1.696 (95%CI 1.114-2.583); p=0.018)], and severe COVID-19 [PR=1.513 (95%CI 1.077-2.342); p=0.040)]. Logistic regression analysis showed that COVID-19 patients with kidney disease was correlated with sepsis [PR=4.318 (95%CI 1.767-10.553); p<0,001] and mortality [PR=1.413 (95%CI 1.664-3.005); p=0.045)].Conclusion. Kidney disease increases the risk for sepsis and mortality in COVID-19 patients.
Karakteristik dan Profil Pengobatan Pasien Diabetes Mellitus Tipe 2 di Puskesmas I Denpasar Selatan Upadhana, Putu Satyakumara; Pramana, Gede Agus Indra; Pertiwi, Putu Restu; Dediyana, I Wayan
Majalah Kedokteran Andalas Vol. 48 No. 3 (2025): MKA July 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i3.p252-257.2025

Abstract

AbstrakTujuan: Diabetes mellitus tipe 2 (DMT2) merupakan suatu penyakit metabolik kronis dengan hiperglikemi yang persisten. Kondisi ini berhubungan dengan berbagai komplikasi. Studi ini bertujuan untuk mengidentifikasi karakteristik klinis dan profil pengobatan pasien DMT2 di Puskesmas I Denpasar Selatan.  Metode: Studi ini merupakan studi deskrpitif observasional dengan pendekatan potong lintang. Studi ini menggunakan data sekunder dari rekam medis pasien DMT2 yang dirawat di Puskesmas I Denpasar Selatan pada 1 Februari 2023 – 28 Februari 2023, dengan menggunakan total sampling. Hasil: Terdapat 50 pasien dimasukkan pada penelitian ini. Sebagian besar berjenis kelamin perempuan (n=29;58,0%), dengan median usia sebesar 60 tahun. Prevalensi hipertensi adalah sebesar 54,0%. Sebagian besar pasien tergolong tidak mengalami obesitas (n=28;56,0%) dan memiliki kadar gula darah puasa yang tidak terkontrol (n=34;68,0%), dengan median gula darah puasa sebesar 160 mg/dL. Mayoritas pasien memiliki durasi pengobatan DMT2 sebesar >10 bulan (n=26;52,0%). Metformin merupakan obat yang paling banyak diberikan pada bulan Februari 2023 (n=43;86,0%), diikuti dengan glimepiride (n=42;84,0%). Sebagian besar pasien memiliki riwayat penggunaan obat selain obat anti diabetes (n=44;88,0%), meliputi simvastatin (n=29;58,0%), amlodipine (n=26; 52,0%), alopurinol (n=21; 42,0%), dan captofril (n=6; 12,0%). Kesimpulan: Sebagian besar pasien berjenis kelamin perempuan, memiliki kadar gula darah puasa yang tidak terkontrol, dan mendapatkan pengobatan metformin.  
Gambaran Karakteristik Pasien Tuberkulosis Pasien di Puskesmas I Denpasar Selatan Upadhana, Putu Satyakumara; Pramana, Gede Agus Indra; Pertiwi, Putu Restu; Dediyana, I Wayan
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p132-138.2024

Abstract

Tujuan: Tuberkulosis (TB) merupakan penyakit yang disebabkan oleh Mycobacterium tuberculosis. Penyakit ini masih memiliki morbiditas dan mortalitas yang sangat besar di seluruh dunia. Studi ini bertujuan untuk mengetahui gambaran karakteristik pasien tuberkulosis di Puskesmas I Denpasar Selatan. Metode: Penelitian ini merupakan penelitian analitik observasional dengan pendekatan potong lintang. Data yang digunakan adalah data sekunder dari data register pasien tuberkulosis di Puskesmas I Denpasar Selatan pada Januari 2022 – Maret 2023 dengan teknik total sampling.Hasil: Sebanyak 53 pasien dilibatkan dalam penelitian ini. Sebagian besar pasien adalah laki-laki (n=34;64,2%), dan berusia <60 tahun (n=46;86,8%). Sebanyak 9 pasien memiliki riwayat diabetes mellitus tipe 2 (17,0%). Sebagian besar pasien terkonfirmasi bakteriologis (n=44;83,0%), dengan hasil pemeriksaan tes cepat molekuler (TCM) yang paling banyak dijumpai adalah MTB detected medium (n=21;47,7%), diikuti dengan MTB detected high (n=9;20,5%), dan MTB detected low (n=8;18,2%). Mayoritas pasien tergolong ke dalam tuberkulosis paru (n=50;94,3%) dan hanya 3 pasien tergolong ke dalam tuberkulosis ekstra paru (n=3;5,7%). Terkait dengan profil pengobatan, mayoritas dari pasien mendapatkan pengobatan kategori I (n=47;88,7%), dan hanya 6 pasien mendapatkan pengobatan dengan dosis harian (n=6;11,3%). Kesimpulan: Sebagian besar pasien tuberkulosis pada studi ini adalah berjenis kelamin laki-laki, berusia <60 tahun, dan terkonfirmasi secara bakteriologis. Mayoritas pasien mendapatkan pengobatan kategori I.
Co-Authors Adhyatma, I Gede Raka Agrasidi, Komang Adya Data Chintya Cahyarini, I Gusti Agung Ayu Dediyana, I Wayan Dewi, Kadek Aprilia Sukma Handayani, Putu Novi I Ketut Agus Somia Laela, Tika Rizki Nur Pertiwi, Putu Restu Pramana, Gede Agus Indra Putri, Amanda Trisliana Dwi Putri, Komang Anjani Sastrawan, I Gede Gita Sastrawan, I Gede Gita Sastrawan Sudarmika, Putu Trisna, Cindy Gracia Umam, Anbiya Khairul Wiguna, I Nyoman Bayu Andika