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All Journal International Journal of Integrated Health Sciences Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Dimmy Prasetya
Divisi Hemato Onkologi, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Padjadjaran/Rumah Sakit Dokter Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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High Tissue Factor Microparticle Level in Major Thalassemic Patients with Pulmonary Hypertension Dimmy Prasetya; Pandji Irani Fianza; Erwan Martanto; Teddy Arnold Sihite
International Journal of Integrated Health Sciences Vol 7, No 2 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n2.1658

Abstract

Objective: To analyze the correlation between tissue factor microparticles (TF-MP) levels and pulmonary hypertension (PH) in adult thalassemic patients.    Methods:  This study was conducted from September to October 2018, using secondary and primary data. The secondary data consisted of the PH parameter, which was retrieved from a 2017 previous study entitled ‘Clinical Characteristic and Complication due to Iron Overload in Thalassaemic Patients‘in 2017 while the primary data were the TF-MP, which were obtained from the analysis of frozen serum of the same population using ELISA method. The mean pulmonary arterial pressure (mPAP) values were obtained from echocardiography results and PH was defined as mPAP >25 mmHg.Results: Seven (16.7%) major thalassemic patients experienced PH. The median values of TF-MP levels were higher among major thalassemic patients with PH when compared to the non-PH patients (1569 vs 11.5 pg/dL; p=0.023). No significant difference was observed in the median TF-MP levels between subjects with splenectomy and subjects without splenectomy (11.6 vs 12.3 pg/dL; p=0.44). There was also no difference in mPAP values between subjects with splenectomy and subjects without splenectomy (18.0 vs 17.0 mmHg; p=0.663). When the median TF-MP levels among major thalassemic patients were analyzed in terms of correlation with transfusion level, no statistically significant difference was seen between subjects who received sufficient transfusions (≥180 mL/kgbb/year) and those who received insufficient transfusions (<180 mL/kgbb/year) (r= 0.138; p=0.390).Conclusions: There is a positive correlation between the TF-MP levels and PH in adult major thalassemic subjects.
Karakteristik Pasien Trombosis Vena Dalam: Tinjauan Sistematik Ebenezer Verian Hutagalung; Teddy Arnold Sihite; Dimmy Prasetya
Majalah Kedokteran Indonesia Vol 71 No 4 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.4-2021-479

Abstract

Pendahuluan: Trombosis vena dalam (TVD) merupakan salah satu penyebab kematian terbesar di dunia. TVD memiliki faktor risiko yang bermacam-macam sehingga presentasi pasien TVD dapat berbeda pada tiap kelompok usia, jenis kelamin, dan ras. Penelitian ini bertujuan untuk memperoleh informasi mengenai karakteristik pasien thrombosis vena dalam.Metode: Penelitian ini menggunakan studi pendekatan kualitatif yang merupakan studi pustaka yang menggunakan buku-buku dan literatur-literatur lainnya sebagai objek utama. Penelitian ini menggunakan mesin pencarian, seperti Pubmed, Google Scholar, dan Clinical Key untuk mendapatkan jurnal-jurnal yang berkaitan dengan karakteristik pasien trombosis vena dalam.Hasil: Dari 17 literatur, ditemukan bahwa karakteristik pasien TVD berbeda pada tiap kelompok usia, jenis kelamin, dan ras. Semakin tua usia pasien, derajat keparahan TVD meningkat karena adanya kondisi lain yang biasanya muncul di usia lanjut. Laki-laki lebih rentan mengalami TVD dari perempuan tanpa faktor risiko reproduktif, seperti kehamilan dan menopause. Orang Afrika memiliki presentasi TVD lebih parah dibandingkan dengan ras lain. Risiko paling rendah ditemukan pada orang Asia, meskipun tidak ada perbedaan mortalitas yang signifikan antar ras.Kesimpulan: Karakteristik pasien TVD (angka kejadian, faktor risiko, lokasi, dan tingkat keparahan) bervariasi pada tiap kelompok usia, jenis kelamin, dan ras.
Co-Authors Ebenezer Verian Hutagalung Erwan Martanto Pandji Irani Fianza Teddy Arnold Sihite Teddy Arnold Sihite