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Hemoglobin Level, Energy Intake, and Body Mass Index of Kebersihan, Keindahan, Kenyamanan Lingkungan Workers in an Academic Institution Maharani, Carmelia Cantika; Farenia, Reni; Fianza, Pandji Irani
Althea Medical Journal Vol 4, No 2 (2017)
Publisher : Althea Medical Journal

Background: Productivity is a priority that is required from every worker. Work productivity of each person is different. The important factors of work productivity are hemoglobin level, energy intake, and body mass index (BMI). The objective of the study was to identifyÂ hemoglobin level, energy intake, and BMI ofÂ Kebersihan, Keindahan, Kenyamanan Lingkungan (K3L) workers in Universitas Padjadjaran, Jatinangor. Methods: A descriptive study was carried out to 80 K3L workers inÂ Universitas Padjadjaran on October 2014. The total number of 80 workers was chosen with cluster random method. Primary data consisted of hemoglobin level measured by HemocueÂ®Hb 201+, dietary consumption recall (2x24 hours), and anthropometry data (weight and height). The collected data were analyzed and presented by frequency tabulation and percentage.Results:The study showed that more than a half of subjects (77%) had normal hemoglobin level. The majority of subjects (47%) had low energy intake. Most of subjects (59%) had normal BMI, 12% subjects were underweight, 18% subjects were overweight, and 11% subjects were obesity. Conclusions: The majority of K3L workers have normal hemoglobin level, energy intake deficiency, and normal BMI.Â DOI:Â 10.15850/amj.v4n2.1089

Prevalensi Penyakit Tidak Menular pada Fasilitas Kesehatan Tingkat Pertama di Kota Bandung Tahun 2013-2015 Adhania, Cindy Cahya; Wiwaha, Guswan; Fianza, Pandji Irani
Jurnal Sistem Kesehatan Vol 3, No 4 (2018): Volume 3 Nomor 4 Juni 2018
Publisher : Universitas Padjadjaran

Penyakit tidak menular (PTM) diprediksi akan meningkat. Di Indonesia, PTM mengalami baik peningkatan maupun penurunan. Adanya perbedaan antara prediksi dengan data dapat dikarenakan terbatasnya data terpublikasi sehingga kurang menggambarkan perkembangan terkini PTM. Untuk mengetahui lebih jauh mengenai perkembangan PTM di Indonesia, dibutuhkan data prevalensi PTM pada daerah tertentu, terutama di Kota Bandung. Tujuan penelitian yaitu mengetahui prevalensi PTM di Kota Bandung dan perkembangannya. Penelitian ini merupakan penelitian deskriptif observasional dengan desain studi potong lintang. Objek penelitian berupa laporan bulanan 1 (LB1) Sistem Pencatatan dan Pelaporan Puskesmas (SP3) Kota Bandung tahun 2013, 2014, dan 2015. Penelitian dilakukan di Kota Bandung pada Bulan Februari 2016-November 2016. Hasil menunjukan bahwa prevalensi PTM di Kota Bandung pada tahun 2013, 2014, dan 2015 secara berurutan yaitu 25,35%, 23,21%, dan 26,98%. Kategori PTM yang meningkat diantaranya penyakit kelainan metabolik. Disimpulkan bahwa telah terjadi peningkatan prevalensi PTM di Kota Bandung dari tahun 2013 ke tahun 2015. Di masa mendatang, diperlukan data prevalensi PTM secara lebih menyeluruh dalam jangka waktu yang lebih lama untuk hasil yang lebih akurat.Kata kunci: Bandung, fasilitas kesehatan tingkat pertama, penyakit tidak menular, prevalensi

NEUROPATI PERIFER PADA PENYANDANG TALASEMIA DI POLIKLINIK HEMATOONKOLOGI RSUP DR HASAN SADIKIN BANDUNG Uni Gamayani,* Fanny Adhy Putri,* Nushrotul Lailiyya,* Pandji Irani Fianza,** Ramdan Panigoro***
NEURONA Vol. 36 No. 3 Juni 2019
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION THALASSEMIA IS AN INHERITED BLOOD DISORDER WITH HIGH PREVALENCE THAT CAN LEAD TO VARIOUS NEUROLOGICAL COMPLICATIONS SUCH AS PERIPHERAL NEUROPATHY PERIPHERAL NEUROPATHY IN THALASSEMIA PATIENTS IS COMMONLY SUBCLINICAL CHRONIC HYPOXIA DUE TO ANEMIA AND IRON DEPOSITION ARE THOUGHT TO BE THE RISK FACTORS FOR NEUROPATHY IN THALASSEMIA NERVE CONDUCTION STUDY NCS IS THE GOLD STANDARD IN DIAGNOSING PERIPHERAL NEUROPATHY

Pengaruh Alfa Tokoferol pada Efek Ototoksik Sisplatin Santosa, Yanuar Iman; Samiadi, Dindy; Aroeman, Nur Akbar; Fianza, Pandji Irani
Majalah Kedokteran Bandung Vol 44, No 4 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Kemoterapi sisplatin memiliki efek samping ototoksik, diperantarai radikal bebas, mengakibatkan kematian selÂ rambut luar koklea, menyebabkan gangguan dengar. Alfa tokoferol memiliki efek otoprotektif terhadap sisplatinÂ pada hewan coba. Diperlukan penelitian lebih lanjut pada manusia. Tujuan penelitian mengukur fungsi pendengaranÂ untuk mengetahui pengaruh pemberian alfa tokoferol per oral pada pencegahan efek ototoksik sisplatin. DilakukanÂ penelitian uji klinis acak di Rumah Sakit Dr. Hasan Sadikin Bandung (RSHS) periode Desember 2011â€“FebruariÂ 2012 pada dua kelompok. Kelompok perlakuan menjalani pengobatan standar kemoterapi sisplatin denganÂ tambahan alfa tokoferol per oral dengan dosis 400 International Unit (IU) per hari sejak 1 hari sebelum kemoterapiÂ selama 30 hari. Kelompok kontrol menjalani pengobatan standar kemoterapi sisplatin. Pemeriksaan fungsiÂ pendengaran dilakukan dengan timpanometri, audiometri, dan distortion product otoacoustic emission (DPOAE)Â sebelum dan setelah kemoterapi siklus pertama dan kedua. Didapatkan hasil kejadian ototoksik setelah siklusÂ pertama lebih rendah secara bermakna pada kelompok 1 (33,3%) dibandingkan dengan kelompok 2 (66,7%)Â (p=0,046; IK=95%). Demikian juga dengan kejadian ototoksik setelah siklus kedua lebih rendah secara bermaknaÂ pada kelompok 1 (50%) dibandingkan dengan kelompok 2 (88,9%) (p=0,027; IK=95%). Simpulan, terapi alfaÂ tokoferol 400 IU per oral dapat mencegah efek ototoksik sisplatin. [MKB. 2012;44(4):205â€“12].Kata kunci: Alfa tokoferol, ototoksik, sisplatinEffects of Alpha Tocopherol Againts Cisplatinâ€“Induced OtotoxicityOtotoxicity is a known side effect of cisplatin chemotherapy due to formation of free radicals causing death toÂ cochlear outer hair cells, resulting in hearing loss. Alpha tocopherol has otoprotective effects towards cisplatin inÂ animal studies. Further human studies are needed. The objective of this study was to measure hearing function toÂ know the otoprotective effects of alpha tocopherol against cisplatin. A randomized control trial was performed atÂ Dr. Hasan Sadikin Hospital Bandung in December 2011â€“February 2012 in 2 groups. The treatment group receivedÂ standard cisplatin chemotherapy treatment and alpha tocopherol 400 International Unit (IU)/day since day 1 beforeÂ a 30-day-treatment. the control group received standard cisplatin chemotherapy treatment. Hearing evaluationÂ was done using tympanometry, audiometry and distortion product otoacoustic emission (DPOAE) before andÂ after the first and second cycles of chemotherapy. Results showed that ototoxic incidence after the first cycle ofÂ chemotherapy was significantly lower in group 1 (33.3%) than group 2 (66.7%) (p=0.046, CI=95%). OtotoxicÂ incidence after the second cycle of chemotherapy was significantly lower in group 1 (50%) than group 2 (88.9%)Â (p=0.027, CI=95%). In conclusion, oral alpha tocopherol 400 IU can prevent cisplatin-induced ototoxicity. [MKB.Â 2012;44(4):205â€“12]Key words: Alpha tocopherol, cisplatin, ototoxicityÂ DOI:Â http://dx.doi.org/10.15395/mkb.v44n4.176

Hypercoagulable State dan Diabetes Melitus Tipe 2: Korelasi antara Fibrinogen dan HbA1c Aprijadi, Hery; Sumantri, Rachmat; Heri, Trinugroho; Irani, Pandji; Oehadian, Amaylia; Arifin, Augusta Y. L.
Majalah Kedokteran Bandung Vol 46, No 1 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Hiperkoagulabilitas merupakan penyebab kelainan vaskular pada diabetes melitus tipe 2 (DM tipe 2). Fibrinogen merupakan petanda hiperkoagulabilitas akibat inflamasi sistemik. Kadar HbA1c dipakai untuk menilai kadar gula darah jangka panjang dan berhubungan dengan petanda inflamasi. Terdapat perbedaan hasil penelitian terdahulu tentang bagaimana hubungan antara kadar fibrinogen dan HbA1c. Ada yang menyatakan hubungan bermakna dan ada pula yang tidak. Tujuan penelitian ini untuk melihat adakah korelasi antara fibrinogen dan HbA1c. Penelitian ini merupakan penelitian potong lintang pada penderita rawat jalan DM tipe 2 di RS Dr. Hasan Sadikin Bandung selama Januariâˆ’Juli 2010. Kriteria inklusi penderita DM tipe 2 yang baru didiagnosis, normotensi, kadar hemoglobin normal, serta tes fungsi hati dan ginjal normal. Dilakukan pemeriksaan kadar fibrinogen, trigliserida, dan HbA1c. Kriteria eksklusi yaitu mendapat obat antiagregasi trombosit, obat antidiabetik oral, atau menderita penyakit autoimun. Analisis statistik berupa Spearman dan regresi digunakan pada penelitian ini. Terdapat 63 subjek yang diikutkan dalam penelitian. Semua subjek memiliki kadar HbA1c lebih dari 6,5% (rata-rata 8,21Â±2,5%). Terdapat 33 penderita (53%) dengan kadar fibrinogen di atas harga normal (rata-rata 416,75Â±102,7 mg/dL). Tidak terdapat korelasi yang bermakna antara kadar fibrinogen dan HbA1c. Simpulan, tidak terdapat korelasi antara kadar fibrinogen dan HbA1c. Meskipun demikian subjek dengan diabetes melitus cenderung mempunyai kadar fibrinogen yang tinggi. [MKB. 2014;46(1):48â€“51]Kata kunci: Diabetes melitus tipe 2, fibrinogen, HbA1c, hypercoagulable stateÂ Hypercoagulable State and Type 2 Diabetes Mellitus: the Correlation between Fibrinogen and HbA1cHypercoagulability has been suggested as a result of type 2 diabetic mellitus vascular disease. Fibrinogen is a marker of hypercoagulability due to systemic inflammation. HbA1c level is used to measure long-term blood glucose level. There was inconsistent findings about the correlation between fibrinogen level and HbA1c. Previous study found a significant correlation between fibrinogen levels and HbA1c, while other study showed different results for this finding. The aim of this study was to determine the correlation between fibrinogen and HbA1c. A cross-sectional study was performed in outpatients type 2 diabetes mellitus (DM) in Dr. Hasan Sadikin General Hospital Bandung during Januaryâˆ’July 2010. Patients with newly diagnosed type 2 DM, normotension, normal hemoglobin level, normal liver function test and normal kidney function test were included in this study. Fibrinogen, trigliseride, and HbA1c levels were examined. The exclusion criteria were patients taking antiplatelet drugs or oral antidiabetic and had autoimmune diseases. Spearman and regression analysis were used in this study. Sixty three subjects were included in this study. All subjects had HbA1c level more than 6.5% (mean 8.21Â±2.5%). Thirty three patients (53%) had fibrinogen level of more than the normal limit (mean 416.75Â±102.7 mg/dL). The mean of trigliseride level was 235.32Â±131.3 mg/dL. No significant correlation between fibrinogen and HbA1c. In conclusion, there is no correlation between the fibrinogen levels and HbA1c. However, subjects with diabetes mellitus tend to have high fibrinogen levels. [MKB. 2014;46(1):48â€“51]Key words: Fibrinogen, HbA1c, hypercoagulable state, type 2 diabetes mellitusÂ DOI:Â 10.15395/mkb.v46n1.227

43 Years Old Female with Acquired Hemophilia Presented with Pseudotumor Ward, Shinta Oktya; Fianza, Pandji Irani
Bioinformatics and Biomedical Research Journal Vol. 1 No. 3 (2018): Volume 1 Issue 3
Publisher : Future Science

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Introduction: Acquired-haemophilia A in women is rare. This disorder is caused by the formation of auto-antibodies to factor VIII. Pseudo-tumor is a complication of hemophilia caused by recurrent bleeding which forms mass due to the presence of blood and necrotic tissue.A woman, 43 years old with complaints of left thigh lumps for 2 weeks before admitted to the hospital. Physical examination found a mass in the left thigh, with a thigh circumference of 34 cm, cystic. Laboratory tests showed coagulation disorders in the form of normal APTT lengthening after a mixing study, 2% factor VIII and 7.12 BU inhibitor levels. The ultrasound results of the femoral region showed heterogeneous cystic lesions with multi-inoculated internal echo and septa in the subcutaneous, the impression involved a muscular layer. Vascularity did not appear in it. The patient was improved with conservative therapy of 500mg corticosteroids and recombinant factor VIII. Pseudotumor hemophilia must be followed up immediately since it may cause further complications in the form of compartment syndrome. A biopsy is contraindicated in pseudotumor hemophilia. Simple imaging modalities are able to distinguish pseudotumor from other tumors. The patient was improved with conservative corticosteroid pulse dose 500g for inhibitor and recombinant factor VIII therapy. Due to limited costs, Recombinant activated factor VIII combined with activated prothrombin complex concentrate was not given.Acquired hemophilia A is a hemorrhagic disease with reduced coagulation factor VIII (F.VIII) activity due to the appearance of autoantibodies (inhibitors) against F.VIII. Hematoma is generally diffuse and very painful (Pseudomotor). In contrast to congenital hemophilia, where joint bleeding rarely occurs in AHA. The two strategies used for the management of AHA with pseudotumor in this patient is hemostatic therapy and immunosuppression.

Hemoglobin Level, Energy Intake, and Body Mass Index of Kebersihan, Keindahan, Kenyamanan Lingkungan Workers in an Academic Institution Carmelia Cantika Maharani; Reni Farenia; Pandji Irani Fianza
Althea Medical Journal Vol 4, No 2 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Productivity is a priority that is required from every worker. Work productivity of each person is different. The important factors of work productivity are hemoglobin level, energy intake, and body mass index (BMI). The objective of the study was to identify hemoglobin level, energy intake, and BMI of Kebersihan, Keindahan, Kenyamanan Lingkungan (K3L) workers in Universitas Padjadjaran, Jatinangor. Methods: A descriptive study was carried out to 80 K3L workers in Universitas Padjadjaran on October 2014. The total number of 80 workers was chosen with cluster random method. Primary data consisted of hemoglobin level measured by Hemocue®Hb 201+, dietary consumption recall (2x24 hours), and anthropometry data (weight and height). The collected data were analyzed and presented by frequency tabulation and percentage.Results:The study showed that more than a half of subjects (77%) had normal hemoglobin level. The majority of subjects (47%) had low energy intake. Most of subjects (59%) had normal BMI, 12% subjects were underweight, 18% subjects were overweight, and 11% subjects were obesity. Conclusions: The majority of K3L workers have normal hemoglobin level, energy intake deficiency, and normal BMI. DOI: 10.15850/amj.v4n2.1089

High Tissue Factor Microparticle Level in Major Thalassemic Patients with Pulmonary Hypertension Dimmy Prasetya; Pandji Irani Fianza; Erwan Martanto; Teddy Arnold Sihite
International Journal of Integrated Health Sciences Vol 7, No 2 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n2.1658

Objective: To analyze the correlation between tissue factor microparticles (TF-MP) levels and pulmonary hypertension (PH) in adult thalassemic patients. Methods: This study was conducted from September to October 2018, using secondary and primary data. The secondary data consisted of the PH parameter, which was retrieved from a 2017 previous study entitled ‘Clinical Characteristic and Complication due to Iron Overload in Thalassaemic Patients‘in 2017 while the primary data were the TF-MP, which were obtained from the analysis of frozen serum of the same population using ELISA method. The mean pulmonary arterial pressure (mPAP) values were obtained from echocardiography results and PH was defined as mPAP >25 mmHg.Results: Seven (16.7%) major thalassemic patients experienced PH. The median values of TF-MP levels were higher among major thalassemic patients with PH when compared to the non-PH patients (1569 vs 11.5 pg/dL; p=0.023). No significant difference was observed in the median TF-MP levels between subjects with splenectomy and subjects without splenectomy (11.6 vs 12.3 pg/dL; p=0.44). There was also no difference in mPAP values between subjects with splenectomy and subjects without splenectomy (18.0 vs 17.0 mmHg; p=0.663). When the median TF-MP levels among major thalassemic patients were analyzed in terms of correlation with transfusion level, no statistically significant difference was seen between subjects who received sufficient transfusions (≥180 mL/kgbb/year) and those who received insufficient transfusions (<180 mL/kgbb/year) (r= 0.138; p=0.390).Conclusions: There is a positive correlation between the TF-MP levels and PH in adult major thalassemic subjects.

Platelet-Derived Microparticle Count in β-Thalassemia Patients with Direct Labeling Monoclonal Antibody CD62P and CD41 Ivan Lumban Toruan; Pandji Irani Fianza; Delita Prihatni
Majalah Kedokteran Bandung Vol 52, No 2 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Thromboembolic events are potentially life-threatening clinical complications found in β-thalassemia patients. The pathogenesis of the hypercoagulable state in β-thalassemia patients results from the degradation of excess α-globin chains in red blood cells, leading to intracellular labile iron accumulation, oxidative stress, and more rigid, deformed, and eventually prematurely damaged red blood cells. This process is associated with the loss of the normal asymmetrical distribution of membrane phosphatidylserine and its exposure to the outer surface of the blood cell membrane resulting in the formation of tenase complexes, prothrombinase, and thrombin complexes. Increased thrombins lead to platelet activation and platelet-derived microparticles synthesis, which in turn contributes to thrombus formation. This study aimed to determine the increase in the platelet-derived microparticle count by direct labeling of CD62P and CD41 monoclonal antibodies in β-thalassemia patients when compared with normal subjects. This was a cross-sectional analytical quantitative study conducted in Dr. Hasan Sadikin General Hospital Bandung and Dharmais Cancer Hospital Jakarta Indonesia between August and September 2019. Sixty patients, divided evenly into β-thalassemia group and control group, were labeled by CD62P and CD41 monoclonal antibodies. Results showed that the β-thalassemia group had a platelet count of 197x103/uL (58–1,261) with a median count for platelet-derived microparticles of 10,553 events/uL (779–90,971) as opposed to 1,861 events/uL (1,244–3,174) in the normal group (p<0.05). Therefore, the platelet-derived microparticle count in the β-thalassemia patients is 5.7 times greater than in the normal subjects.Jumlah Platelet Derived Microparticles pada Pasien Thalassemia β dengan Metode Pelabelan Langsung Antibodi Monoklonal CD62P dan CD41Kejadian tromboemboli berpotensi komplikasi klinis yang mengancam jiwa ditemukan pada pasien thalassemia β. Patogenesis keadaan hiperkoagulasi pada pasien thalassemia β akibat dari degradasi rantai globin α berlebih dalam sel darah merah yang menghasilkan akumulasi besi labil intraseluler, dan mengarah pada stres oksidatif serta sel darah merah yang lebih kaku dan cacat, dengan akibat kerusakan prematur. Proses ini dikaitkan dengan hilangnya distribusi asimetris normal dari fosfatidilserin membran dan paparannya pada permukaan luar membran sel darah, yang meyebabkan pembentukan kompleks tenase, kompleks protrombinase dan trombin. Peningkatan trombin mengarah pada aktivasi trombosit dan sintesis platelet derived microparticles yang selanjutnya berkontribusi pada pembentukan trombus. Tujuan dari penelitian ini adalah mengetahui peningkatan jumlah platelet derived microparticles dengan metode pelabelan langsung antibodi monoklonal CD62P dan CD41 pada pasien thalassemia β dibanding dengan subjek normal. Penelitian ini merupakan suatu penelitian kuantitatif dengan metode analitik potong lintang yang dilakukan di RSUP Dr. Hasan Sadikin Bandung dan Rumah Sakit Kanker Dharmais Jakarta antara bulan Agustus dan September 2019. Enam puluh pasien, dibagi secara merata menjadi kelompok thalassemia β dan kelompok kontrol, diberi label oleh CD62P dan CD41 antibodi monoklonal. Hasil penelitian menunjukkan kelompok thalassemia β memiliki jumlah trombosit 197x103/uL (58–1.261) dengan jumlah median platelet derived microparticles 10.553 partikel/uL (779–90.971) dibanding dengan 1.861 partikel/uL ( 1,244–3,174) pada kelompok normal (p<0,05). Simpulan, jumlah platelet derived microparticles pada pasien thalassemia β adalah 5,7 kali lebih besar daripada pada subjek normal.

Prevalensi Penyakit Tidak Menular pada Fasilitas Kesehatan Tingkat Pertama di Kota Bandung Tahun 2013-2015 Cindy Cahya Adhania; Guswan Wiwaha; Pandji Irani Fianza
Jurnal Sistem Kesehatan Vol 3, No 4 (2018): Volume 3 Nomor 4 Juni 2018
Publisher : Universitas Padjadjaran

Penyakit tidak menular (PTM) diprediksi akan meningkat. Di Indonesia, PTM mengalami baik peningkatan maupun penurunan. Adanya perbedaan antara prediksi dengan data dapat dikarenakan terbatasnya data terpublikasi sehingga kurang menggambarkan perkembangan terkini PTM. Untuk mengetahui lebih jauh mengenai perkembangan PTM di Indonesia, dibutuhkan data prevalensi PTM pada daerah tertentu, terutama di Kota Bandung. Tujuan penelitian yaitu mengetahui prevalensi PTM di Kota Bandung dan perkembangannya. Penelitian ini merupakan penelitian deskriptif observasional dengan desain studi potong lintang. Objek penelitian berupa laporan bulanan 1 (LB1) Sistem Pencatatan dan Pelaporan Puskesmas (SP3) Kota Bandung tahun 2013, 2014, dan 2015. Penelitian dilakukan di Kota Bandung pada Bulan Februari 2016-November 2016. Hasil menunjukan bahwa prevalensi PTM di Kota Bandung pada tahun 2013, 2014, dan 2015 secara berurutan yaitu 25,35%, 23,21%, dan 26,98%. Kategori PTM yang meningkat diantaranya penyakit kelainan metabolik. Disimpulkan bahwa telah terjadi peningkatan prevalensi PTM di Kota Bandung dari tahun 2013 ke tahun 2015. Di masa mendatang, diperlukan data prevalensi PTM secara lebih menyeluruh dalam jangka waktu yang lebih lama untuk hasil yang lebih akurat.Kata kunci: Bandung, fasilitas kesehatan tingkat pertama, penyakit tidak menular, prevalensi

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