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All Journal Medula JK Unila (Jurnal Kedokteran Universitas Lampung)
Puji Indah Permatasari
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Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Peran Metformin sebagai Terapi pada Kanker Kolorektal Puji Indah Permatasari
Medula Vol 10 No 2 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i2.70

Abstract

In Indonesia, based on WHO data in 2014, colorectal cancer ranks second in men and third in women. Diet and lifestyle factors are risk factors for colorectal cancer. Limiting the consumption of cooked meat and red meat, replacing it with fish as an alternative source of protein and avoiding cooking meat at high temperatures are some strategies to reduce the risk of colorectal cancer.3,4 Insulin is thought to trigger tumorigenesis either directly by affecting epithelial tissue through its interaction in insulin / insulin-like growth factor receptors, or indirectly through its effect on other modulators, such as sex hormones and adiponectin. Metformin is a drug that is believed to have properties to treat diabetes since the 17th century. Retrospective studies show that metformin is also associated with a reduced risk of cancer, suggesting a potential role as an anticancer agent.2 The mechanism of metformin as a preventive or adjuvant therapy in colorectal cancer is based on inhibition of growth and proliferation of cancer cells through its main mechanism, affecting the AMPK / mTOR pathway. This is the basis for the potential of metformin to be used as a preventive therapy or adjuvant therapy in cancer, especially colorectal cancer.
Mekanisme Ivabradine sebagai Terapi Gagal Jantung dengan Penurunan Fraksi Ejeksi Jhons Fatriyadi Suwandi; Giska Tri Putri; Puji Indah Permatasari
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2227

Abstract

Gagal jantun merupakan sindrom klinis yang kompleks dimana fungsi-fungsi jantung abnormal dengan gejala klinis dan tanda berupa berkurangnya curah jantung, paru, kongesti sistemik atau keduanya saat fase istirahat atau beraktivitas. Gagal jantung merupakan bagian akhir dari perjalanan penyakit jantung. Peningkatan prevalensi gagal jantung akan menambahkan beban sosio-ekonomi, dan akan terus bertambah akibat rehospitalisasi. Terapi pada gagal jantung ditujukan untuk meningkatkan kualitas hidup pasien, menurunkan gejala serta mengurangi angka rehospitalisasi. Pada pasien dengan gagal jantung dengan penurunan fraksi ejeksi dengan denyut jantung di atas 70 kali permenit, Ivabradine diindikasikan untuk mengoptimalkan terapi.Kata kunci: Gagal jantung, Ivabradine, Terapi
Co-Authors Giska Tri Putri Jhons Fatriyadi Suwandi