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Mekanisme Ivabradine sebagai Terapi Gagal Jantung dengan Penurunan Fraksi Ejeksi Jhons Fatriyadi Suwandi; Giska Tri Putri; Puji Indah Permatasari
Jurnal Kedokteran Universitas Lampung Vol 3, No 1 (2019): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v3i1.2227

Abstract

Gagal jantun merupakan sindrom klinis yang kompleks dimana fungsi-fungsi jantung abnormal dengan gejala klinis dan tanda berupa berkurangnya curah jantung, paru, kongesti sistemik atau keduanya saat fase istirahat atau beraktivitas. Gagal jantung merupakan bagian akhir dari perjalanan penyakit jantung. Peningkatan prevalensi gagal jantung akan menambahkan beban sosio-ekonomi, dan akan terus bertambah akibat rehospitalisasi. Terapi pada gagal jantung ditujukan untuk meningkatkan kualitas hidup pasien, menurunkan gejala serta mengurangi angka rehospitalisasi. Pada pasien dengan gagal jantung dengan penurunan fraksi ejeksi dengan denyut jantung di atas 70 kali permenit, Ivabradine diindikasikan untuk mengoptimalkan terapi.Kata kunci: Gagal jantung, Ivabradine, Terapi
Hubungan Durasi Menderita Diabetes Melitus Tipe 2 dengan Kejadian Katarak di RSUD DR. H. Abdul Moeloek Provinsi Lampung Tahun 2018 Febri Nadyanti; Rani Himayani; Giska Tri Putri; M Yusran
Essence of Scientific Medical Journal Vol 17 No 1 (2019): Volume 17 No. 1 (Januari-Juni 2019) ESSENTIAL: Essence Of Scientific Medical Jou
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2019.v17.i01.p06

Abstract

Background: Cataract is one of the complications in type 2 diabetes mellitus caused by the buildup of sorbitol. The factors that influence occurrence of cataract is the duration of suffering type 2 diabetes mellitus. Purpose: The aim of this study was to determine the relationship among duration of type 2 diabetes mellitus with the occurrence of cataract in general hospital RSUD DR. H. Abdul Moeloek Lampung Province in 2018. Method: The design used in this study was observational analytic with a cross-sectional approach. There were 30 samples of patient with type 2 diabetes mellitus in the general hospital RSUD DR. H. Abdul Moeloek Lampung Province in 2018. Samples were chosen by total sampling and the data was analyzed by using chi square. Result: Duration of suffering from type 2 diabetes mellitus >10 years was as much as 40%, while 60% duration was ?10 years. From 30 participants, 53,3% had cataract and 46,7% had no cataract. Duration of suffering type 2 diabetes mellitus was statistically related with the occurrence of cataract with p value = 0,000 (p<0,05). Conclusion: Based on this study, we can conclude that there was a relation between duration of type 2 diabetes mellitus with the occurrence of cataracts in general hospital RSUD DR. H. Abdul Moeloek Lampung Province in 2018. Keywords: Cataract, Duration of Type 2 Diabetes Mellitus, Sorbitol
Usia Ibu Sebagai Faktor Risiko Terjadinya Plasenta Previa Salma Khairunnisa Hero; Rodiani; Giska Tri Putri
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.554

Abstract

Placenta previa is complete or partial closure of the inner cervical ostium by the placenta. Placenta previa is one of the causes of postpartum hemorrhage and is a condition that can cause morbidity and mortality for both mother and baby. Placenta previa has the potential to become an emergency. Placenta previa is located in the lower uterine segment and causes obstruction of the cervix. This can make the vaginal birth process more difficult and risky, even leading to death from bleeding. There are several factors that can be risk factors for placenta previa, namely parity, history of curettage, cesarean section, previous history of placenta previa, multiple pregnancies, tumors, and age. At the age of <20 years the reproductive system is still immature. The endometrium in the immature uterine fundus causes the placenta to attach and grow in the lower uterine segment. At the age of> 35 years, the reproductive system has decreased, one of which is a decrease in blood flow to the uterus. So that the placenta will implant in the part that has more blood flow.
PERBEDAAN KONTAMINASI TELUR SOIL TRANSMITTED HELMINTH PADA TANAH DI DAERAH PEDESAAN DAN PERKOTAAN Alvan Muhammad Hibatullah Santoso; Hanna Mutiara; Giska Tri Putri; Jhons Fatriyadi Suwandi
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.479

Abstract

Soil Transmitted Helminth is an infection that causes malnutrition, anemia, growth retardation. Transmission is through contact with eggs or larvae in the soil. Cases of STH infection in Indonesia are high in areas of poor sanitation, poor hygiene and lack of understanding of clean and healthy lifestyles. Therefore, this study aims to determine the contamination of STH eggs on soil in rural and urban areas. This research is a cross-sectional study with purposive sampling. The number of samples is 90 soil sample points in rural and urban areas and then the univariate and bivariate analysis tests are carried out using the pearson chi-square Test. The number of STH contamination in rural areas was 29 out of 90 samples with 26 samples of Ascaris lumbricoides, 2 samples of Hookworm, and 1 sample of Trichuris trichiura. STH egg contamination in urban areas was 22 out of 90 samples with details of 17 samples of Ascaris lumbricoides, 3 samples of Hookworm, and 2 samples of Trichuris trichiura. Based on the results of the pearson chi-square Test analysis, a p-value of 0.467 was obtained. There is no difference in contamination of STH eggs on soil in rural and urban areas.
Potensi Senyawa Alami dalam Polifenol dengan Mekanismenya untuk Melawan Kanker Mesensy, Natasya; Putri, Giska Tri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.933

Abstract

Globally, cancer is the leading cause of death because its pathophysiology includes multifactorial components. In general, various things mediate its development, such as genetic mutations, toxin intake, radiation exposure, unhealthy food, and work pressure. To increase the chance of cure from cancer and the possibility of survival, early detection, and appropriate treatment are needed. In the last decade, the high content of bioactive compounds contained in nutraceutical components has been considered as a complement in food, food supplements, and medicines. The medicines here include appropriate treatment to fight cancer without worrying about anticancer side effects that can cause adverse responses. Compounds in nutraceuticals are natural bioactive ingredients that have anticancer properties, which can kill cells that have metastasized or have become cancerous without being toxic to surrounding normal cells. This effect is proven when these natural bioactive compounds are contained in conventional medicine and show that nutraceutical supplementation contributes to the success of cancer treatment as an anticancer. This review examines the current knowledge from various literature regarding several natural bioactive extracts that contain certain polyphenolic compounds. The activity of this compound can be seen from the inhibition of cell proliferation, anti-inflammatory action, and antioxidant activity. Therefore, nutraceutical supplementation can be recommended along with conventional treatment to obtain a better therapeutic response in cancer patients.
Hubungan Determinan Sosial Kesehatan dengan Infeksi Toksoplasma gondii Jasmine, Almaina Puteri; Mutiara, Hanna; Suwandi, Jhons Fatriyadi; Putri, Giska Tri
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.938

Abstract

Toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis. The high rate of toxoplasmosis infection in the Lampung region reaches 88.23%. Typically, toxoplasmosis presents no symptoms but can pose serious problems for individuals with compromised immune systems or pregnant women. The purpose of this study is to identify the relationship between social health determinant factors such as age, gender, educational level, occupation, and residence address with the incidence of T. gondii infection among patients at Dr. H. Abdul Moeloek Hospital. The aim is to identify individuals at risk of toxoplasmosis infection early so prevention can be done immediately. This study is an analitic quantitative research with a cross-sectional design. The study population consists of patients at Dr. H. Abdul Moeloek Hospital who have been screened for toxoplasmosis from 2017 to 2023, with a sample size of 93 samples. A total of 67 samples were tested positive for toxoplasmosis, while 26 samples tested negative with the sampling technique using total sampling. Data were collected from patients medical records and were analyzed by univariate and bivariate analysis using Chi-square method. The results indicate a relationship between age (p 0.002), gender (p <0.001), and educational level (p <0.001) with the incidence of Toxoplasma gondii infection among patients at Dr. H. Abdul Moeloek Hospital from 2017 to 2023.
Hubungan Antara Kadar D-Dimer dengan Angka Mortalitas pada Pasien Dewasa Terkonfirmasi Coronavirus Disease 19 di RSUD Abdul Moeloek Bandar Lampung Periode Tahun 2020 – 2021.docx Attila Firjatullah, Muhammad Daffa; Tjiptaningrum, Agustyas; Putri, Giska Tri
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1055

Abstract

Lampung is one of the regions with the highest Case Fatality Rate (CFR) in Indonesia, which was 7.7% on September 16, 2021. Several studies have shown that D-Dimer levels influenced the mortality of confirmed Covid-19 patients. This study aimed to analyze the correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 adult patients. This research was an observational analytic study using a cross-sectional approach. The population of this study was all confirmed covid-19 adult patients who fulfilled the inclusion and exclusion criteria in Abdul Moeloek Hospital Medical Record Installation from 2020 to 2021. The samples were taken using simple random technique. Data collected were D-Dimer level, mortality rate, and patient’s personal information. Data were analyzed by Chi-Square using statistical data processing program. There were 94 subjects admitted in our study, divided into groups of survivors and non-survivors. From the non-survivors’ group, 43 (91%) subjects had a high D-Dimer level. The Chi-Square analysis showed a correlation between D-Dimer levels and the mortality rate of Covid-19 patients (p-value = 0,001). Statistically, there was a significant correlation between D-Dimer levels and the mortality rate of confirmed Covid-19 patients.
A Tinjauan Pustaka: Diagnosis Dan Tatalaksana Katarak Kongenital Adha Nurhaniefah, Azmi; Putri, Giska Tri
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1095

Abstract

Congenital cataract is a disorder of the loss of transparency of the lens, sometimes causing a change in its refractive index that occurs during the first year or childhood of life. Congenital cataract is a rare eye disease, with a variable prevalence of 0.6-9.3/10,000 live births. However, this disease remains one of the main causes of visual loss in children. This disease is considered a preventable cause of blindness. However, late diagnosis and treatment will also have an adverse impact and can cause severe permanent blindness. Congenital cataracts have a significant impact on affected patients due to the low age of the target population and the deprivation amblyopia that can occur as a complication of this disorder. The method used in compiling this literature review is through searching literature from various sources using online searches with Google Scholar, Pubmed, and NCBI instruments within the last 5 years and using the keywords congenital cataract, diagnosis, management, management, treatment data that have been collected were analyzed scientifically and systematically. The data analysis technique used is descriptive and argumentative. The results of this study indicate that the diagnosis of congenital cataracts can be made through anamnesis, physical examination, and supporting examinations. The main treatment with good visual results is through early intervention with surgical procedures. The surgical techniques used include anterior Capsulotomy, Lens Aspiration & Vitrectomy anterior/Lansectomy, and IOL Implantation.
LAPORAN KASUS ASMA EKSASERBASI SEDANG PADA PASIEN ASMA PERSISTEN BERAT TIDAK TERKONTROL DENGAN OBESITAS DAN ANEMIA Mustofa, Syazili; Ramadhan, Muhammad Alif; Putri, Giska Tri; Carolia, Novita; Wisnugroho, Cahyo
JURNAL KEDOKTERAN RAFLESIA Vol 10 No 2 (2024)
Publisher : UNIVERSITAS BENGKULU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/juke.v10i2.38273

Abstract

Asma merupakan penyakit heterogen yang disebabkan oleh inflamasi kronis saluran pernafasan. Pada tahun 2019, prevalensi asma di Indonesia berjumlah 4,5%. Provinsi Lampung tercatat memiliki prevalensi asma sejumlah 1,6% di tahun 2018. Kasus seorang wanita, usia 42 tahun, mengeluhkan sesak nafas 30 menit Sebelum Masuk Rumah Sakit (SMRS). Sesak nafas terakhir muncul 2 bulan yang lalu dan sesak nafas saat malam hari muncul 2 bulan yang lalu. Sesak nafas muncul ketika dipicu oleh debu, asap, dan cuaca dingin. Sesak nafas memberat ketika malam dan pagi hari. Keluhan penyerta berupa batuk tidak berdahak dan riwayat alergi terhadap debu, asap, dan cuaca dingin. Pemeriksaan fisik didapatkan pasien bernafas cepat, wheezing, dan obesitas grade II. Pada pemeriksaan penunjang, pasien mengalami anemia, eusinophilia, dan indikasi penyakit paru kronis pada gambaran rontgen thorax. Diagnosis pasien berupa asma eksaserbasi sedang persisten berat tidak terkontrol dengan obesitas dan anemia. Pasien diberikan tatalaksana farmakologi berupa nebulisasi Short Acting Beta Agonist (SABA) dan nebulisasi kortikosteroid. Setelah 3 hari rawat inap, pasien mengalami perbaikan klinis dan diperbolehkan pulang
RISK FACTORS FOR PULMONARY TUBERCULOSIS COINFECTION IN HIV/AIDS PATIENTS Ildha Rosendy Kurnianda; Apriliana, Ety; Putri, Giska Tri; Wardani, Dyah Wulan Sumekar Rengganis
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1318

Abstract

Tuberculosis and HIV co-infection is a major public health problem in many parts of the world. In Indonesia, tuberculosis (TB) is an opportunistic infection that most often occurs in people living with HIV/AIDS (PLWHA). HIV infection increases susceptibility to Mycobacterium tuberculosis, thereby increasing the risk of developing TB. The World Health Organization (WHO) estimates that TB causes 13% of deaths in AIDS sufferers. Tuberculosis (TB) and HIV co-infection occurs when a person is infected with Mycobacterium tuberculosis and HIV at the same time. People with HIV have a 30 times greater risk of suffering from TB than people who are not infected with HIV. There is a significant relationship between these two infections, where each infection accelerates the development of the other infection. HIV infection can trigger reactivation of latent TB into active TB, while TB infection can worsen the clinical condition of patients who have been infected with HIV. The aim of this study was to determine various risk factors for pulmonary tuberculosis co-infection in HIV/AIDS patients. The method used is qualitative with literature study as a data collection technique. The results obtained were alcohol consumption and extra-pulmonary TB, education level, monthly income, occupation, family history of PTB, lack of appetite, balanced diet, maintaining healthy nutrition, smoking, and stopping taking medication if you felt the condition was under control and the incidence of PTB were factors associated with an increase in pulmonary tuberculosis co-infection..