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Bintang Abadi Siregar
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Potensi Isoflavon Genistein Sebagai Terapi Suportif Imunonutrisi Pada Pasien Kanker Payudara Regina Triswara; Ahmad Farishal; Bintang Abadi Siregar
Medula Vol 9 No 4 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v9i4.242

Abstract

Breast cancer is a malignancy in breast cells that grow out of control with a variety of mechanisms and risk factors. Breast cancer can be started from the ducts or lobular breasts. Breast cancer has a high incidence and high mortality in the Asian region due to various things, especially the process of early detection and therapy. Prevention stage is preferred over surgical or chemotherapy therapy. The condition of breast cancer patients must have a strong and tough immune system to supply cancer cells so that the need for proper nutrition is very much needed. Soybeans are rich in isoflavones known as antioxidants, antibacterial and most recently have anticancer potential. Genistein isoflavones in soybeans will be more active after the fermentation process and show the potential of cancer cell inhibitors by changing the phase of carcinogenesis with hormone receptor pathways and Nf-Kb-Akt signaling. Genistein is also proven as an inhibitor of angiogenesis in cancer cells. Further clinical trials need to be carried out on safety and the right dosage to be applied as immunonutrition in breast cancer patients.
Potensi Curcumin sebagai Modalitas Terapi Suportif Pada Pasien Kanker Payudara Amira Puri Zahra; Ahmad Farishal; Bintang Abadi Siregar
MAJORITY Vol 9 No 1 (2020): MAJORITY
Publisher : Majority

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Breast cancer is a malignancy in breast cells in the ducts or lobes due to mutations in gene level. Gene mutations, especially BRCA1 and BRCA2, are the dominant genes in breast cancer that activate carcinogenesis that causes immune defects. Decreased immunity must be improved and supported one of them using special nutrition improvements that have supportive therapy in breast cancer. Curcumin has potential as a nutrient that increases immunity and has an apotosis effect, suppresses metastases, regulates microRNA and stops the angiogenesis process promoted by VEGF in cancer cells. Curcumin is a natural ingredient obtained from Curcuma longa alias turmeric which has been used widely as a spice in the Asian region. The potential anticancer and antioxidant available in curcumin should be given at a minimum dose of 3.6gram and absorbed by the intestine only 1% but it is easily deposited in the brain, liver and lungs. The use of nano and injection routes are expected to increase the bioavability of curcumin.
Co-Authors Ahmad Farishal Amira Puri Zahra Regina Triswara