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All Journal Berkala Ilmiah Kimia Farmasi Aksi Kita: Jurnal Pengabdian Kepada Masyarakat
Suzana
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Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Environmental Science Medicine & Pharmacology Social Sciences Other

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Prediction of the Potential of Benzoxazinone, 2-phenyl-4H-benzo[1,3]oxazin-4-one, and 2-[2-(4-methoxyphenyl)vinyl]-3,1-benzoxazin-4-one as New Anti-Tuberculosis Nofianti, Kholis Amalia; Hakim, Luqmanul; Suzana; Ifadotunikamah, Farida
Berkala Ilmiah Kimia Farmasi Vol. 11 No. 1 (2024): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v11i1.56056

Abstract

Even though it had been almost five decades, the decline in the prevalence of tuberculosis had still been low due to the rise of drug resistance. Recently, benzoxazinone compounds had begun to gain potential as anti-tuberculosis agents because of their interesting structure and similarity to isoniazid, the most widely used TB drug, which had reportedly experienced many cases of resistance. This research tested the ability of the core compound benzoxazinone and its two derivatives to bind to the enoyl ACP-CoA receptor, which was responsible for the formation of mycobacterial walls. In silico tests were carried out using pkcsm to determine the pharmacokinetic profile, and molecular docking tests using Molegro Virtual Docker were conducted to determine the pharmacodynamic profile through binding to the enoyl ACP-CoA receptor. The selected receptors were downloaded from the protein data bank with the code 2IDZ. The research results showed that the three test compounds had good intestinal and skin absorption profiles, indicating that they could be administered orally or transdermally. The docking results, expressed by moldock score and rerank score, showed that the three test compounds had better potential compared to isoniazid. Thus, the test compounds could be developed as new anti-tuberculosis agents. Keywords:  Tubercolosis, Benzoxazinone, Mycobacterium Tuberculosis, Pkcsm, Molegro Virtual Docker
Peningkatan Kesadaran Kesehatan Lansia melalui Skrining Tekanan Darah dan Gula Darah: Studi Kasus di Desa Nampu, Kecamatan Gemarang, Kabupaten Madiun Akhnita Ziyadatul 'Iffa; Suzana; Fildzah Nadiyah Auni; Maulidiyah; Mega Tantri Putri; Melati Adinda Putri; Mohammad Amirin Nurul Hidayat; Nurul Muzammil; Titus Adimasto
Aksi Kita: Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 5 (2025): OKTOBER
Publisher : Indo Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/n5zyqm15

Abstract

Skrining kesehatan secara gratis pada lansia meliputi dua pengukuran yaitu tekanan darah dan gula darah sewaktu. Skrining hipertensi dilakukan dengan pengecekan tekanan darah pada lansia karena lansia memiliki risiko yang lebih tinggi terkena hipertensi daripada usia muda. Skrining gula darah juga dilakukan karena tingkat gula darah pada lansia lebih berisiko mengalami peningkatan dan juga gula darah yang tinggi dapat menurunkan kualitas hidup lansia. Tujuan pelaksanaan kegiatan ini yaitu kegiatan ini dapat meningkatkan kesadaran lansia terhadap kesehatan masing-masing individu, khususnya terkait penyakit tidak menular (PTM) berupa hipertensi dan diabetes, serta cara pencegahan dan pengendaliannya. Metode pelaksanaan kegiatan ini yaitu pengukuran tekanan darah dan gula darah sewaktu, serta edukasi dan konseling. Pelaksanaan  telah dilakukan pengukuran tekanan darah dan juga gula darah sewaktu, kepada sebanyak 42 lansia. Hasil pengukuran tekanan darah menunjukkan bahwa sebanyak 30 dari 42 lansia mengalami hipertensi atau tekanan darah tinggi dan 1 menunjukkan hasil gula darah yang tinggi. Setelah mendapatkan hasil skrining, diberikan edukasi kepada peserta mengenai hasil pengukuran tekanan darah dan gula darah, serta implikasi kesehatan dari hasil tersebut.
Co-Authors Akhnita Ziyadatul 'Iffa Fildzah Nadiyah Auni Ifadotunikamah, Farida Kholis Amalia Nofianti Luqmanul Hakim Maulidiyah Mega Tantri Putri Melati Adinda Putri Mohammad Amirin Nurul Hidayat Nurul Muzammil Titus Adimasto