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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Al Iman: Jurnal Keislaman dan Kemasyarakatan Al Iman: Jurnal Keislaman dan Kemasyarakatan Aksi Kita: Jurnal Pengabdian Kepada Masyarakat
Maulidiyah
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Religion Agriculture, Biological Sciences & Forestry Economics, Econometrics & Finance Education Environmental Science Social Sciences Other

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Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAc 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Cytotoxic of Usnic Acid Isolated from Ramalina sp.: Cytotoxic of Usnic Acid Isolated from Ramalina sp. Darmawan, Akhmad; Maulidiyah; Megawati; Ariani, Novita; Aisya, Sitti; Sukirno; Randy, Ahmad; Primahana, Gian; Hendra, Medi; Nurdin, Muhammad
Journal of Tropical Life Science Vol. 14 No. 2 (2024)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.14.02.14

Abstract

Ramalina sp. (Ramalinaceae) is a type of lichen known to contain many active secondary metabolite compounds that have the potential to be used as medicine or medicinal raw materials. One of the biological activities possessed by Ramalina sp. lichen is its anticancer activity. This research aims to isolate and identify active secondary metabolite compounds from the methanol extract of the Ramalina sp. lichen and to find out the cytotoxic activity of the isolated compound against MCF7 breast cancer cells. Compound 1 (usnic acid) was successfully isolated from fraction A. The isolation and purification process was carried out starting with a maceration process using acetone solvent, followed by silica gel column chromatography using a gradient solvent system consisting of n-hexane, n-hexane:EtOAc, EtOAc, EtOAc:MeOH, and MeOH with 5% increment of polarity to obtain 17 fractions (F-1 to F-17). From the 17 fractions obtained, fraction 3 (F-3) and fraction 4 (F-4) (eluted with n-hexane:EtOAc 30%), which had the same TLC profile, were combined and named as fraction A. Compound 1 (50 mg) is a yellow needle crystal that was formed in a bottle of fraction A, which was obtained after the process of combining fractions F-3 and F-4 and solvent evaporation process. The crystals were then separated and purified with CHCl3 and MeOH. Compound 1 was then characterized based on spectroscopic data. Various spectroscopic analysis data, including FTIR, 1D- and 2D-NMR, and LC-ESI-MS, show that Compound 1 is a dibenzofuran derivative compound with 18 carbons (3 from carbonyl groups (C=O) and 3 from methyl groups) and 2 hydroxyl (-OH). Cytotoxicity assay showed that at a low concentration of 18.75 ug/mL, Compound 1 caused a 67.06% decrease in MCF7 viability
Peningkatan Kesadaran Kesehatan Lansia melalui Skrining Tekanan Darah dan Gula Darah: Studi Kasus di Desa Nampu, Kecamatan Gemarang, Kabupaten Madiun Akhnita Ziyadatul 'Iffa; Suzana; Fildzah Nadiyah Auni; Maulidiyah; Mega Tantri Putri; Melati Adinda Putri; Mohammad Amirin Nurul Hidayat; Nurul Muzammil; Titus Adimasto
Aksi Kita: Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 5 (2025): OKTOBER
Publisher : Indo Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/n5zyqm15

Abstract

Skrining kesehatan secara gratis pada lansia meliputi dua pengukuran yaitu tekanan darah dan gula darah sewaktu. Skrining hipertensi dilakukan dengan pengecekan tekanan darah pada lansia karena lansia memiliki risiko yang lebih tinggi terkena hipertensi daripada usia muda. Skrining gula darah juga dilakukan karena tingkat gula darah pada lansia lebih berisiko mengalami peningkatan dan juga gula darah yang tinggi dapat menurunkan kualitas hidup lansia. Tujuan pelaksanaan kegiatan ini yaitu kegiatan ini dapat meningkatkan kesadaran lansia terhadap kesehatan masing-masing individu, khususnya terkait penyakit tidak menular (PTM) berupa hipertensi dan diabetes, serta cara pencegahan dan pengendaliannya. Metode pelaksanaan kegiatan ini yaitu pengukuran tekanan darah dan gula darah sewaktu, serta edukasi dan konseling. Pelaksanaan  telah dilakukan pengukuran tekanan darah dan juga gula darah sewaktu, kepada sebanyak 42 lansia. Hasil pengukuran tekanan darah menunjukkan bahwa sebanyak 30 dari 42 lansia mengalami hipertensi atau tekanan darah tinggi dan 1 menunjukkan hasil gula darah yang tinggi. Setelah mendapatkan hasil skrining, diberikan edukasi kepada peserta mengenai hasil pengukuran tekanan darah dan gula darah, serta implikasi kesehatan dari hasil tersebut.
STRATEGI PENDANAAN MELALUI LEASING SOLUSI UNTUK MENINGKATKAN AKSES MODAL DAN DIVERSIFIKASI INSTRUMEN INVESTASI BAGI MASYARAKAT Inayatah, Meli; Maulidiyah; Setiawan, M.; Zia, Ahmad Zihad Luqmansyah; Rofiko, Arina
Al Iman: Jurnal Keislaman dan Kemasyarakatan Vol. 9 No. 2 (2025): Al-Iman Jurnal Keislaman dan Kemasyarakatan
Publisher : STID Raudlatul Iman Sumenep

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Leasing has become an effective financing alternative, especially for micro, small, and medium enterprises (MSMEs), to acquire necessary assets without needing significant upfront capital. This article discusses the role of leasing in enhancing MSMEs' access to capital and its contribution to investment instrument diversification. Despite offering numerous benefits, the implementation of leasing still faces challenges, such as limited public understanding of its mechanisms, regulatory barriers, and economic uncertainty. Therefore, improvements in regulations, financial literacy, and tailoring leasing products to MSME needs are essential for the sector's optimal development. This article also provides recommendations for financial institutions and the government to enhance support for MSMEs in utilizing leasing as a more flexible and affordable financing alternative. Abstrak Leasing telah menjadi alternatif pembiayaan yang efektif, terutama bagi pelaku usaha mikro, kecil, dan menengah (UMKM), untuk memperoleh aset yang diperlukan tanpa harus mengeluarkan modal besar di awal. Artikel ini membahas peran leasing dalam meningkatkan akses modal bagi UMKM, serta kontribusinya dalam diversifikasi instrumen investasi. Meskipun menawarkan banyak manfaat, implementasi leasing masih menghadapi tantangan, seperti kurangnya pemahaman masyarakat mengenai mekanisme leasing, hambatan regulasi, dan ketidakpastian ekonomi. Oleh karena itu, dibutuhkan perbaikan regulasi, peningkatan literasi keuangan, dan penyesuaian produk leasing dengan kebutuhan UMKM agar sektor ini dapat berkembang secara optimal. Artikel ini juga memberikan saran bagi lembaga keuangan dan pemerintah untuk meningkatkan dukungan terhadap UMKM dalam memanfaatkan leasing sebagai alternatif pembiayaan yang lebih fleksibel dan terjangkau.
STRATEGI PENDANAAN MELALUI LEASING SOLUSI UNTUK MENINGKATKAN AKSES MODAL DAN DIVERSIFIKASI INSTRUMEN INVESTASI BAGI MASYARAKAT Inayatah, Meli; Maulidiyah; Setiawan, M.; Zia, Ahmad Zihad Luqmansyah; Rofiko, Arina
Al Iman: Jurnal Keislaman dan Kemasyarakatan Vol. 9 No. 2 (2025): Al-Iman Jurnal Keislaman dan Kemasyarakatan
Publisher : STID Raudlatul Iman Sumenep

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Leasing has become an effective financing alternative, especially for micro, small, and medium enterprises (MSMEs), to acquire necessary assets without needing significant upfront capital. This article discusses the role of leasing in enhancing MSMEs' access to capital and its contribution to investment instrument diversification. Despite offering numerous benefits, the implementation of leasing still faces challenges, such as limited public understanding of its mechanisms, regulatory barriers, and economic uncertainty. Therefore, improvements in regulations, financial literacy, and tailoring leasing products to MSME needs are essential for the sector's optimal development. This article also provides recommendations for financial institutions and the government to enhance support for MSMEs in utilizing leasing as a more flexible and affordable financing alternative. Abstrak Leasing telah menjadi alternatif pembiayaan yang efektif, terutama bagi pelaku usaha mikro, kecil, dan menengah (UMKM), untuk memperoleh aset yang diperlukan tanpa harus mengeluarkan modal besar di awal. Artikel ini membahas peran leasing dalam meningkatkan akses modal bagi UMKM, serta kontribusinya dalam diversifikasi instrumen investasi. Meskipun menawarkan banyak manfaat, implementasi leasing masih menghadapi tantangan, seperti kurangnya pemahaman masyarakat mengenai mekanisme leasing, hambatan regulasi, dan ketidakpastian ekonomi. Oleh karena itu, dibutuhkan perbaikan regulasi, peningkatan literasi keuangan, dan penyesuaian produk leasing dengan kebutuhan UMKM agar sektor ini dapat berkembang secara optimal. Artikel ini juga memberikan saran bagi lembaga keuangan dan pemerintah untuk meningkatkan dukungan terhadap UMKM dalam memanfaatkan leasing sebagai alternatif pembiayaan yang lebih fleksibel dan terjangkau.
Co-Authors Ahmad Randy Aisya, Sitti Akhmad Darmawan Akhnita Ziyadatul 'Iffa Ariani, Novita Fildzah Nadiyah Auni Inayatah, Meli Medi Hendra, Medi Mega Tantri Putri Megawati Melati Adinda Putri Mohammad Amirin Nurul Hidayat Muhammad Nurdin Nurul Muzammil Primahana, Gian Rofiko, Arina Setiawan, M. SUKIRNO Suzana Titus Adimasto Zia, Ahmad Zihad Luqmansyah