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All Journal Althea Medical Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Farmasi Klinik Indonesia Journal of General Procedural Dermatology and Venereology Indonesia
Hendra Gunawan
Departemen Ilmu Kesehatan Kulit Dan Kelamin Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Economics, Econometrics & Finance Engineering Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health

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Journal : Berkala Ilmu Kesehatan Kulit dan Kelamin

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Metabolic Syndrome In Psoriasis Vulgaris Patient Wulan Yuwita; Hendra Gunawan; Unwati Sugiri; Dendi Sandiono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.897 KB) | DOI: 10.20473/bikk.V28.3.2016.251-255

Abstract

Background: The management of metabolic syndrome in psoriasis vulgaris is rather complicated, including lifestyle modification, diet intake intervention, increasing daily activities, and managing the comorbidity factors. Purpose: Management of metabolic syndrome in psoriasis vulgaris requires holistic approach. Case: A case of metabolic syndrome with psoriasis vulgaris in a-56-year-old woman was reported with chief complaint generalized erythematous plaques, papules, scales, and hyperpigmented macules. Blood pressure was 160/90 mmHg with central obesity and waist circumference was 98 centimeters. The patient manifested with onychodystrophy and subungual hyperkeratosis digiti I pedis bilateral. Fasting blood glucose was 119 mg/dL, and triglyceride was 185 mg/dL. Management: Patient management included methotrexate, bisoprolol, captopril, simvastatin, lifestyle modification, and diabetic diet (1300 kkal and protein 0.8 mg/kg/body weight/day). Conclusion: Holistic management revealed a good response in this case. The initial psoriasis area and severity index (PASI) score before therapy was 24.8, became 9.0 after therapy on day 155th of observation.
The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia Oki Suwarsa; Fatima Aulia Khairani; Syawalika Ulya Isneny; Erda Avriyanti; Hartati Purbo Dharmadji; Miranti Pangastuti; Endang Sutedja; Hendra Gunawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.200-204

Abstract

Background: Methotrexate (MTX) and cyclosporine have been used as effective systemic mono-therapy for psoriasis. Several factors are considered to switch monotherapy to combination therapy because monotherapy is no longer effective and has higher side effects. Hence,clinicians have avoided systemic therapy combinations due to its toxicity. However, some studies showed that this combination therapy could be usedeffectively for psoriasis patients. Purpose: This study aimed to analyze the efficacy and adverse effects of systemic MTX and cyclosporine combination therapy in Indonesian psoriasis vulgaris patients. Methods: The retrospective study assessed the effectiveness of 3 monthsmono-therapyand combination therapy of systemic MTX and cyclosporine in psoriasisvulgaris patients from 2016–2017 in Dermatology Clinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia. Result: Psoriasis area and severity index (PASI) score 90 were achieved in the group MTX (50%) and cyclosporine group (50%), while none in the combination group.However, eight patients (50%) in group MTX and cyclosporine reached the primary endpoint of PASI 50. One patient in cyclosporine group had adverse effects on kidney profiles. Nonetheless, other patients had no biochemical changes. But, there was no significant difference in the change of PASI between each group (p=0.102). Conclusion: We propose that combination therapy of MTX and cyclosporine is relatively safe and efficacious in treating Indonesian psoriasis vulgaris patients. This combination treatment isas effective as MTX or cyclosporinemono-therapy.
Co-Authors Achadiyani Andrew Citrawan Dendi Sandiono Endang Sutedja Erda Avriyanti Fatima Aulia Khairani Hartati Purbo Dharmadji Laila Tsaqilah Miranti Pangastuti Oki Suwarsa Pati Aji Achdiat Rachel Marsella Rahardjo Renasha Firda Hanannisa Risa Miliawati Ronny Lesmana Sudigdo Adi Sunaryati S. Adi Syawalika Ulya Isneny Unwati Sugiri Wulan Yuwita