Abdillah, Aqyl Hanif
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Association between Online Study Stress in COVID-19 Pandemic with Constipation Abdillah, Aqyl Hanif
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.9611

Abstract

Latar Belakang: Konstipasi sering terjadi dan mempengaruhi 15% populasi di seluruh dunia. Konstipasi dapat menurunkan kualitas hidup pasien dan dapat dipengaruhi oleh banyak faktor, termasuk stres. Stres juga umum, terutama pada siswa, menyebabkan tingkat kecenderungan bunuh diri yang lebih tinggi dan gangguan dari berbagai aspek. Saat ini, di masa pandemi COVID-19, stres lebih sering terjadi karena berbagai penyebab. Salah satu penyebabnya adalah belajar online di masa pandemi COVID-19. Tujuan: Untuk mengetahui hubungan antara stres belajar online pada masa pandemi COVID-19 dengan konstipasi pada mahasiswa kedokteran USU angkatan 2018 tahun 2021. Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Sampel dalam penelitian ini adalah 112 mahasiswa kedokteran USU angkatan 2018 yang memenuhi kriteria inklusi dan dikumpulkan dengan menggunakan metode consecutive sampling. Data primer diperoleh dengan menggunakan kuesioner online-shared di google form dan diajukan oleh responden. Kemudian dilakukan analisis univariat dan bivariat pada data menggunakan SPSS, yang terakhir menggunakan Fisher's Exact Test. Hasil: Pada penelitian ini 78 siswa (69,6%) mengalami stres dan 8 siswa (7,1%) mengalami konstipasi. Analisis antara kedua variabel menggunakan Fisher's Exact Test menunjukkan nilai p sebesar 0,431, yang dapat diartikan tidak ada hubungan antara stres belajar online pada pandemi COVID-19 dengan konstipasi. Kesimpulan: Stres belajar online pada pandemi COVID-19 tidak terkait dengan sembelit. Kata kunci: Sembelit, Pandemi, Studi Online, Stres Background: Constipation is common and affects 15% of population worldwide. Constipation can decrease the quality of life of the patients and may be affected by many factors, including stress. Stress too, is general, especially in students, causing higher rates in suicidal tendency and impairments from various aspects. Today, in COVID-19 pandemic, stress is more common due to numerous causes. One of the causes is online studying in COVID-19 pandemic, which might trigger stress in students. Objectives: To determine the relationship between online study stress in COVID-19 pandemic with constipation in the year 2018 medical students of USU in 2021. Method: This study is an analytical observational study using a cross-sectional design. Samples in this study were 112-year 2018 medical students of USU who satisfied the inclusion criteria and gathered by using a consecutive sampling method. Primary data were acquired by using an online- shared questionnaire in the google form and submitted by the respondents. Then, univariate, and bivariate analyses were performed on the data using SPSS, with the latter using fisher’s exact test. Results: In this study, 78 students (69,6%) were stressed and 8 students (7,1%) were constipated. The analysis between the two variables using fisher’s exact test shown the p value about 0,431, which can be interpreted as no association found between online study stress in COVID-19 pandemic with constipation. Conclusion: Online study stress in COVID-19 pandemic is not associated with constipation. Keywords: Constipation, Pandemic, Online study, Stress
Potency of Various MicroRNA as Sputum Biomarker in Lung Cancer Alnaz, Ahmad Razi Maulana; Abdillah, Aqyl Hanif; Ridha, Rasyid
Smart Medical Journal Vol 5, No 1 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i1.54585

Abstract

Introduction: Lung cancer is one the deadliest cancer known. Current method using low-dose CT scan to screen lung cancer applied are proved to reduce mortality, but lack in accuracy leading to overdiagnosis. Current researches are mostly seeking for a non-invasive and cost-effective method, hence biomarkers such as microRNA has a potency to screen and diagnose lung cancer. This literature review aimed to discuss the potency of microRNA in sputum as a biomarker in screening lung cancer.Methods: The study is conducted by literature searching for related journals in search engines such as PubMed, Science Direct, and Google Scholar with keywords. 35 articles were included with relevance and within 10 years publication.Result: MicroRNA is a short non-coding RNA which regulates gene expression. It acts in an oncogene or tumor suppressor gene regulation. DNA mutations or defects occurred in cancer particularly in lung cancer causes increase or decrease of microRNA expression. Alterations of microRNA expression in sputum detected by rt-PCR may represent progressions of lung cancer from a cell cycle dysregulation and provides better sensitivity and specificity among other biomarkers. Combinations of miRNA species offer increase of  sensitivity and specificity. Particular types of microRNA are able to classify the types of lung cancer in progress.Conclusion: MicroRNA has the promising potency and strong accuracy with a non-invasive and cost-effective procedure in detecting early signs of lung cancer occurrence and can be further applied as biomarker used in lung cancer.Keywords: Biomarker; Lung Cancer; microRNA; Screening; Sputum