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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Tropical and Infectious Disease Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Hadiyanto, Jessica Novia
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Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The ‘black fungus' Co-Infection in COVID-19 Patients : A Review Hadiyanto, Jessica Novia; Wilda, Friska; Cahyadi, Alius; Adisuhanto, Marcella
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 2 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i2.27450

Abstract

Mucormycosis is one type of fungal disease, associated with a poor prognosis if not promptly diagnosed and managed because its highly aggressive tendency. Although it is a rare disease, a rapid increase in cases of mucormycosis associated with COVID-19 is being reported. Mostly, risk factors for this disease are uncontrolled diabetes mellitus, other immunosuppressive conditions and corticosteroid therapy. Immune dysfunction, lung pathology and corticosteroid therapy in COVID-19 patients making it more susceptible to develop fungal infection including mucormycosis. The combination of steroid therapy and underlying diabetes mellitus in COVID-19 also can augment immunosuppression and hyperglycemia. Control of hyperglycemia, early treatment with liposomal amphotericin B, and surgery are three important factors in mucormycosis therapy that essential for successful management. However, in this COVID-19 pandemic situation, that management strategies are compromised. First, hyperglicemia can be aggravated by glucocorticoid, therapy that used widely for COVID-19 especially in severe case. Second, patients with ARDS and multiorgan dysfunction can prevent timely diagnostic for imaging and other testing, so appropriate therapy that should be given will be delayed. Last, the essential service in hospital such surgery in this pandemic era reduced signifi cantly to prevent the spread of COVID-19. This review was created with the aim mucormycosis co-infection can be considered in patients with COVID-19, especially with known risk factor. Prompt and rapid diagnosis are important for eff ective therapy and decreasing case fatality rate. The use of steroid in mild cases, utilization of higher doses of steroid and drugs that targeting immune pathway should be avoided. 
A rare case of Salmonella sp septic arthritis in a patient with systematic lupus erythematosus (SLE) Steffanus, Mario; Yusuf, Cindy; Hadiyanto, Jessica Novia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202306

Abstract

Septic arthritis is considered as a medical emergency which can lead to significant morbidity and cause substantial mortality, especially if the diagnosis is delayed. Prolonged use of immunosuppressive and cytotoxic medications as therapy for systemic lupus erythematosus (SLE) causing patient susceptible to secondary infection. However, septic arthritis due to Salmonella sp. is very rare,  makes this is an important extraintestinal manifestation especially in immunosuppressed patients. We presented a case of 25 y.o. female diagnosed with SLE 3 m.o. earlier presented with fever and arthritis on her left genu for 1 wk duration. Genu ultrasonography showed synovitis genu sinistra with fluid volume of 1-2 cc on recessus lateral genu sinistra. The patient was further analysis on her synovial fluid was conducted, the gram stained smear of the fluid showed >25 leucocytes, low power field, and Salmonella sp. was isolated from her synovial fluid analysis. The patient was given intravenous ciprofloxacin and discharged home well. Septic arthritis should always be considered in any patients on long-term immunosuppression state who present with acutely swollen joints. It considered as an important medical emergency with high mortality and morbidity. Hence, prompt recognition, joint aspiration with administration of systemic antibiotics and appropriate surgical intervention plays a pivotal role to minimize morbidity and mortality.
Anemia Penyakit Kronis Hadiyanto, Jessica Novia; Gracia, Margareth; Cahyadi, Alius; Steffanus, Mario
Majalah Kedokteran Indonesia Vol 68 No 10 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.10-2018-216

Abstract

Anemia is commonly found in patients with chronic diseases and causing increased in morbidity and mortality. The prevalence of anemia of chronic disease is the second highest after iron deficiency anemia. Anemia of chronic disease oftenly occurs with iron deficiency anemia therefore both of them showed low in serum iron level. However, we should differentiate these two kinds of anemia in order to give the specific treatment. Some iron parameters have to be extracted to differentiate them. The main management for anemia of chronic disease is to treat the underlying causes.
Co-Authors Adisuhanto, Marcella Alius Cahyadi Margareth Gracia, Margareth Mario Steffanus Wilda, Friska Yusuf, Cindy