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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Patologi Indonesia
Neti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Physics Public Health

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Hubungan Kepadatan Tumor-Associated-Macrophages dan TumorAssociated-Neutrophils dengan Karakteristik Klinikohistopatologi pada Pasien Limfoma Hodgkin Nadya Virana Putri; Neti; Riana Sari Puspita Rasyid; Krisna Murti
Majalah Patologi Indonesia Vol 30 No 2 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.287 KB) | DOI: 10.55816/mpi.v30i2.471

Abstract

BackgroundThe development and aggressiveness of tumor cells were influenced by tumor microenvironment. Tumor-Associated-Macrophages(TAMs) and Tumor-Associated-Neutrophils (TANs) are components of tumor microenvironment, contribute to development and growthof tumor cells. The aim of this research was to analyse correlation of TAMs and TANs densities with clinicohistopathologiccharacteristics of patients i.e. age, gender, location, and subtype.MethodsA case series was conducted. The samples were paraffin blocks of Hodgkin lymphoma patients at Anatomic Pathology DepartmentFaculty of Medicine Universitas Sriwijaya/RSUP Dr. Mohammad Hoesin Palembang. Among 44 cases of Hodgkin lymphomadiagnosed from 1stJanuari 2015 to 30th October 2019, only 31 cases were included. Immunohistochemistry was performed by usinganti-CD163 antibody and neutrophils were identified by morphologic appearances. The results were correlated to characteristicfactors. Statistical analysis was performed using Spearman and Lambda test with significant consideration if p<0.05.ResultsThe study results showed 30 cases of classical Hodgkin lymphoma (CHL) and 1 case of NLPHL. CHL has only 3 variants LR(lymphocyte-rich) (60%), MC (mixed-cellularity) (26.7%), and NS (nodular sclerosis) (13.3%). Hodgkin lymphoma is most commonlyfound in males (61.3%). Tumor were mostly found in the head and neck, and patient ages were majority in the age group 20-29 years,40-49 years, and over 50 years. Spearman test showed there was a significant correlation between density of TAMs with ages(p=0.043).ConclusionHigh density of TAM was correlated with age, however, there was no correlation between TAN and clinicohistopathologiccharacteristics of Hodgkin lymphoma.
Effect of Use Hormonal Progestin Birth Control on Length of Use, Incidence of Menstrual Cycle Disorders in Birth Control Acceptors in Muara Enim District in 2024 Nency, Olivia; Utami, Desiani Putri; Devi, Desna Pramita; Farhan, Laila; Sari, Meyta; Fitri, Mona; Neti; Juliani, Rosdiana; Sapitri, Lidia Aryani
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.8932

Abstract

This study aims to determine the effect of progestin hormonal contraceptive use on the duration of use and the incidence of menstrual cycle disorders among contraceptive acceptors in Muara Enim District in 2024. The method used is a correlational design with a cross-sectional approach. The population in this study consisted of all hormonal contraceptive acceptors in Muara Enim District, with a sample size of 853 people, determined using G Power software. Data analysis was conducted using the Spearman’s rho test. The statistical test results showed a p-value of 0.000 (<0.05), indicating a significant relationship between hormonal contraceptive use and menstrual cycle disorders. A correlation coefficient of 0.28 indicates a fairly strong and positive relationship. Furthermore, there is a relationship between the duration of hormonal contraceptive use and menstrual cycle disorders, with a p-value of 0.000 (<0.05) and a correlation coefficient of 0.39, suggesting a moderate and positive relationship in the same direction. These findings are expected to provide valuable information for healthcare providers to offer more accurate recommendations regarding potential menstrual cycle disorders in progestin hormonal contraceptive users, enabling patients to better understand the possible risks associated with this contraceptive method.
Co-Authors Devi, Desna Pramita Farhan, Laila Fitri, Mona Juliani, Rosdiana Krisna Murti Nadya Virana Putri Nency, Olivia Riana Sari Puspita Rasyid Sapitri, Lidia Aryani Sari, Meyta Utami, Desiani Putri