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All Journal MEDIA MEDIKA INDONESIANA Jurnal Kedokteran Brawijaya Jurnal Kedokteran Diponegoro Biomedical Journal of Indonesia Care : Jurnal Ilmiah Ilmu Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research
Selamat Budijitno
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Ki-67 and HER2-Negative Status as Predictive Factors for Recurrence and Progression in Breast Cancer: Implications for Treatment Strategies Chemy Wiryawan Cahyono; Selamat Budijitno
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1266

Abstract

Background: Breast cancer remains a significant health challenge, with HER2-negative subtypes representing a majority of cases. Ki-67, a marker of cell proliferation, has emerged as a potential prognostic factor in various cancers, including breast cancer. This study aimed to evaluate the association of Ki-67 expression and HER2-negative status with tumor characteristics, treatment response, and disease progression in breast cancer patients. Methods: A retrospective cross-sectional study was conducted at Dr. Kariadi General Hospital, Semarang, Indonesia. Data from 94 patients diagnosed with breast cancer were collected, including immunohistochemical profiles, HER2 status, Ki-67 index, treatment regimens, and tumor size. Statistical analysis was performed using SPSS version 25.0 for Windows. Results: The majority of patients (50%) presented with Luminal B-type breast cancer, and 77.7% had a Ki-67 index >20%. HER2-negative status was observed in 78.7% of patients. No significant correlation was found between HER2-negative status and the type of therapy given (p=0.131) or tumor size (p=0.467). Similarly, Ki-67 expression >20% did not correlate significantly with the type of therapy (p=0.070) or tumor size (p=0.156). Conclusion: While Ki-67 and HER2-negative status are recognized as important prognostic factors in breast cancer, this study did not find a significant association with treatment modalities or tumor size in the studied population. Further research with a larger sample size and longer follow-up is needed to validate these findings and explore the complex interplay of Ki-67, HER2 status, and other clinical variables in breast cancer progression.
Effects of Artemisia Vulgaris Extract on Apoptotic Index and Caspase-8 Sugiharto, Jonathan; Selamat Budijitno
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.486

Abstract

Background. Worldwide incidence of breast cancer is still high. Surgical intervention is mainly used as primary treatment with other supplementary modality such as chemoterapy, radioterapy, and immunotherapy such as Artemisia vulgaris (AV). This study was aimed to analyze the increase in apoptotic effect response of adriamycin-cyclophosphamide on C3H mice model of adenocarcinoma breast cancer provided with Artemisia vulgaris extract. Methods. This research is a post-test only control group design. Twenty four C3H mice were randomly selected and put into 4 groups: K (control group), P1 (Chemoterapy only), P2 (extract only) and P3 (chemoterapy-extract combination). Breast adenocarcinoma was taken from inoculated donor mice. Chemoterapy regiment of 0.18 mg Adriamycin and 1.8 mg Cyclophosphamide were given in 2 cycles. Thirteen miligrams (0.2 mL) of AV extract was given orally once daily. Apoptotic index and Caspase-8 expression were graded with immunohistochemistry stain. Results. Mean value of p53 and caspase-8 expression in K, P1, P2, P3 groups were 22,06 + 1,73, 37,16 + 1,20, 24,60 + 1,08, 39,78 + 1,19 and 17.16 + 1,28, 26,20 + 1,11, 24.60 + 1,08, 39,78 + 1,19, respectively. Statistical analysis showed significant differences in apoptotic index between group K vs P1, P3 (p = 0,001), P1 vs P2 (p = 0,001), P1 vs P3 (p = 0,035), P2 vs P3 (p = 0,001) and for Caspase-8 between K vs P1, P3 (p = 0,001), K vs P2 (p = 0,048), P1 vs P2 (p = 0,001), P1 vs P3 (p = 0,039), P2 vs P3 (p = 0,001). We found a significant correlation between apoptotic index and Caspase-8 expression. (p = 0,047 and r = 0,883). Conclusion. Artemisia vulgaris can increase the adriamycin-cyclophosphamide chemoterapy effectiveness on C3H Mice Model of Breast Adenocarcinoma.
Effects of Artemisia Vulgaris Extract on Apoptotic Index and Caspase-8 Sugiharto, Jonathan; Selamat Budijitno
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.486

Abstract

Background. Worldwide incidence of breast cancer is still high. Surgical intervention is mainly used as primary treatment with other supplementary modality such as chemoterapy, radioterapy, and immunotherapy such as Artemisia vulgaris (AV). This study was aimed to analyze the increase in apoptotic effect response of adriamycin-cyclophosphamide on C3H mice model of adenocarcinoma breast cancer provided with Artemisia vulgaris extract. Methods. This research is a post-test only control group design. Twenty four C3H mice were randomly selected and put into 4 groups: K (control group), P1 (Chemoterapy only), P2 (extract only) and P3 (chemoterapy-extract combination). Breast adenocarcinoma was taken from inoculated donor mice. Chemoterapy regiment of 0.18 mg Adriamycin and 1.8 mg Cyclophosphamide were given in 2 cycles. Thirteen miligrams (0.2 mL) of AV extract was given orally once daily. Apoptotic index and Caspase-8 expression were graded with immunohistochemistry stain. Results. Mean value of p53 and caspase-8 expression in K, P1, P2, P3 groups were 22,06 + 1,73, 37,16 + 1,20, 24,60 + 1,08, 39,78 + 1,19 and 17.16 + 1,28, 26,20 + 1,11, 24.60 + 1,08, 39,78 + 1,19, respectively. Statistical analysis showed significant differences in apoptotic index between group K vs P1, P3 (p = 0,001), P1 vs P2 (p = 0,001), P1 vs P3 (p = 0,035), P2 vs P3 (p = 0,001) and for Caspase-8 between K vs P1, P3 (p = 0,001), K vs P2 (p = 0,048), P1 vs P2 (p = 0,001), P1 vs P3 (p = 0,039), P2 vs P3 (p = 0,001). We found a significant correlation between apoptotic index and Caspase-8 expression. (p = 0,047 and r = 0,883). Conclusion. Artemisia vulgaris can increase the adriamycin-cyclophosphamide chemoterapy effectiveness on C3H Mice Model of Breast Adenocarcinoma.
Co-Authors Chemy Wiryawan Cahyono Eriawan Agung Nugroho Gery Rifano Hardanto Gery Rifano Hardanto Hardian Hardian Hardian Najatullah Paramita Nindya Hapsari Rafika Syah Putra Saputro, Bayu Teguh Siwi Ariana Sugiharto, Jonathan Suhartono Suhartono Yan Wisnu Prajoko