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Association between chest X-ray score and clinical outcome in COVID-19 patients: A study on modified radiographic assessment of lung edema score (mRALE) in Indonesia Rahayu, Dwi RP.; Rusli, Musofa; Bramantono, Bramantono; Widyoningroem, Anita
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.691

Abstract

Radiological examinations such as chest X-rays (CXR) play a crucial role in the early diagnosis and determining disease severity in coronavirus disease 2019 (COVID-19). Various CXR scoring systems have been developed to quantitively assess lung abnormalities in COVID-19 patients, including CXR modified radiographic assessment of lung edema (mRALE). The aim of this study was to determine the relationship between mRALE scores and clinical outcome (mortality), as well as to identify the correlation between mRALE score and the severity of hypoxia (PaO2/FiO2 ratio). A retrospective cohort study was conducted among hospitalized COVID-19 patients at Dr. Soetomo General Academic Hospital Surabaya, Indonesia, from February to April 2022. All CXR data at initial admission were scored using the mRALE scoring system, and the clinical outcomes at the end of hospitalization were recorded. Of the total 178 COVID-19 patients, 62.9% survived after completing the treatment. Patients within non-survived had significantly higher quick sequential organ failure assessment (qSOFA) score (p<0.001), lower PaO2/FiO2 ratio (p=0.004), and higher blood urea nitrogen (p<0.001), serum creatinine (p<0.008) and serum glutamic oxaloacetic transaminase (p=0.001) levels. There was a significant relationship between mRALE score and clinical outcome (survived vs deceased) (p=0.024; contingency coefficient of 0.184); and mRALE score of ≥2.5 served as a risk factor for mortality among COVID-19 patients (relative risk of 1.624). There was a significant negative correlation between the mRALE score and PaO2/FiO2 ratio based on the Spearman correlation test (r=-0.346; p<0.001). The findings highlight that the initial mRALE score may serve as an independent predictor of mortality among hospitalized COVID-19 patients as well as proves its potential prognostic role in the management of COVID-19.
Role of Chest CT Scan to Predict Malignancy on Mediastinal Mass Widyaningrum, Saraswati; Widyoningroem, Anita; Sensusiati, Anggraini Dwi; Kusumastuti, Etty Hary
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14218

Abstract

Mediastinal mass is becoming a global health problem due to high mortality. The heterogeneous mediastinal components make the symptoms of mediastinal mass diverse. CT scans are still the imaging modality for examining mediastinal mass before surgery or other therapies. In this study, we evaluate whether a CT scan could predict the malignancy of mediastinal mass, which is expected to help establish a pre-surgical or pre-biopsy diagnosis. Sixty-two samples were taken consecutively from mediastinal mass patients who came to Dr. Soetomo General Academic Hospital to undergo a CT scan of the thorax with contrast and histopathology examination (core biopsy or open biopsy), which was carried out in the period from December 2019 to March 2024. The results of the CT scan imaging used in this study variable include mass location, mass shape, mass size, infiltration with surrounding organs, attenuation values before contrast administration, after contrast administration, and additional attenuation before and after contrast administration. The CT scan and histopathology results were compared, and multivariate analysis was performed to obtain predictor factors. The location of the mediastinal mass (anterior, medius, posterior), the solid heterogeny component, cystic, calcification, mass shape, organ infiltration, and contrast enhancement value could significantly predict the mediastinal mass's malignancy. If obtained simultaneously, the organ infiltration and contrast enhancement value >20 HU can indicate whether a mediastinal mass is malignant with a specificity of up to 100%.
Role of Chest CT Scan to Predict Malignancy on Mediastinal Mass Widyaningrum, Saraswati; Widyoningroem, Anita; Sensusiati, Anggraini Dwi; Kusumastuti, Etty Hary
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14137

Abstract

Mediastinal mass is becoming a global health problem due to high mortality. The heterogeneous mediastinal components make the symptoms of mediastinal mass diverse. CT scans are still the imaging modality for examining mediastinal mass before surgery or other therapies. In this study, we evaluate whether a CT scan could predict the malignancy of mediastinal mass, which is expected to help establish a pre-surgical or pre-biopsy diagnosis. Sixty-two samples were taken consecutively from mediastinal mass patients who came to Dr. Soetomo General Academic Hospital to undergo a CT scan of the thorax with contrast and histopathology examination (core biopsy or open biopsy), which was carried out in the period from December 2019 to March 2024. The results of the CT scan imaging used in this study variable include mass location, mass shape, mass size, infiltration with surrounding organs, attenuation values before contrast administration, after contrast administration, and additional attenuation before and after contrast administration. The CT scan and histopathology results were compared, and multivariate analysis was performed to obtain predictor factors. The location of the mediastinal mass (anterior, medius, posterior), the solid heterogeny component, cystic, calcification, mass shape, organ infiltration, and contrast enhancement value could significantly predict the mediastinal mass's malignancy. If obtained simultaneously, the organ infiltration and contrast enhancement value >20 HU can indicate whether a mediastinal mass is malignant with a specificity of up to 100%.